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J Biol Chem, Vol. 273, Issue 6, 3152-3157, February 6, 1998
From the LIM domain-containing transcription factors are
required for embryonic survival and for the determination of many cell
types. The combinatorial expression of the LIM homeodomain proteins
Isl1, Isl2, Lhx1, and Lhx3 in subsets of developing motor neurons
correlates with the future organization of these neurons into motor
columns with distinct innervation targets, implying a functional role for LIM homeodomain protein combinations in the specification of
neuronal identity. NLI is a widely expressed, dimeric protein that has
been shown to specifically interact with the LIM domains of LIM
domain-containing transcription factors. The present studies demonstrate that NLI mediates homo- and heteromeric complex formation between LIM domain transcription factors, requiring both the N-terminal dimerization and C-terminal LIM interaction domains of NLI. Although the interaction between most LIM homeodomain proteins is dependent on
NLI, a direct interaction between the LIM domains of Lhx3 and the
homeodomains of Isl1 and Isl2 was also observed. This interaction was
disrupted by NLI, demonstrating that the conformational state of
Lhx3-Isl1/Isl2 complexes is modified by NLI. Evidence indicating that
NLI facilitates long range enhancer-promoter interactions suggests that
NLI-dependent LIM domain transcription factor complexes are
involved in communication between transcriptional control elements.
The Nuclear LIM Domain Interactor NLI Mediates Homo- and
Heterodimerization of LIM Domain Transcription Factors
, Biomedical Sciences Graduate Program and the
** Department of Medicine, University of California at San Diego, La
Jolla, California 92093-0650 and the ¶ Gene Expression Laboratory,
The Salk Institute for Biological Studies,
La Jolla, California 92037
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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