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J Biol Chem, Vol. 273, Issue 7, 4119-4128, February 13, 1998
,,,
From the Colony-stimulating factor-1 (CSF-1) is a
hematopoietic growth factor that is released by osteoblasts and is
recognized to play a critical role in bone remodeling in
vivo and in vitro. CSF-1 is synthesized as a soluble
or cell-surface protein. It is unclear, however, whether human
osteoblasts express both molecular forms of CSF-1, and whether these
isoforms can independently mediate osteoclastogenesis. In the present
study, using a combination of quantitative reverse transcriptase
polymerase chain reaction, flow cytometry, and Western immunoblot
analysis, we have demonstrated that human osteoblast-like cells as well
as primary human osteoblasts express the cell-surface form of CSF-1
both constitutively and in response to parathyroid hormone and tumor
necrosis factor. Furthermore, using an in vitro co-culture
system, we have shown that cell-surface CSF-1 alone is sufficient to
support osteoclast formation. These findings may be especially
significant in view of evidence that direct cell-to-cell contact is
critical for osteoclast formation, and suggest that differential
regulation of expression of the CSF-1 isoforms may influence osteoclast
function modulated by osteotropic hormones.
Section of Comparative Medicine, the
§ Department of Internal Medicine, and the ¶ Department
of Orthopedics and Rehabilitation, Yale University School of Medicine,
New Haven, Connecticut 06520
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