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J Biol Chem, Vol. 273, Issue 7, 4135-4142, February 13, 1998
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From the We report the identification of rat and human
cDNAs for a type 1 membrane protein that contains a novel
six-cysteine immunoglobulin-like domain and a mucin domain; it is named
kidney injury molecule-1 (KIM-1). Structurally, KIM-1 is a member of
the immunoglobulin gene superfamily most reminiscent of mucosal
addressin cell adhesion molecule 1 (MAdCAM-1). Human KIM-1 exhibits
homology to a monkey gene, hepatitis A virus cell receptor 1 (HAVcr-1),
which was identified recently as a receptor for the hepatitis A virus.
KIM-1 mRNA and protein are expressed at a low level in normal
kidney but are increased dramatically in postischemic kidney.
In situ hybridization and immunohistochemistry
revealed that KIM-1 is expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules. Structure and expression data suggest that KIM-1 is an epithelial cell adhesion molecule up-regulated in the cells, which are dedifferentiated and
undergoing replication. KIM-1 may play an important role in the
restoration of the morphological integrity and function to postischemic
kidney.
Renal Unit, Medical Services, Massachusetts
General Hospital East and the Department of Medicine, Harvard
Medical School, Boston, Massachusetts 02129, and ¶ Biogen
Incorporated, Cambridge, Massachusetts 02142
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