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J Biol Chem, Vol. 273, Issue 9, 4883-4891, February 27, 1998
From INSERM U127, Hôpital Lariboisière, 75475 Paris
Cedex 10, France
Increasing evidence suggests that mineralo- and
glucocorticoids modulate cardiovascular homeostasis via the effects of
circulating components generated within the adrenals but also through
local synthesis. The aim of this study was to assess the existence of such a steroidogenic system in heart.
Using the quantitative reverse transcriptase-polymerase chain reaction,
the terminal enzymes of corticosterone and aldosterone synthesis
(11 Chronic regulation of this intracardiac system was then examined. As in
adrenals cardiac 11
Myocardial Production of Aldosterone and Corticosterone in
the Rat
PHYSIOLOGICAL REGULATION
-hydroxylase and aldosterone synthase, respectively) were
detected in the rat heart. This pathway was shown to be physiologically active, since production of aldosterone, corticosterone, and their precursor, deoxycorticosterone, was detected in both the homogenate and
perfusate of isolated rat hearts using radioimmunoassay after Celite
column chromatography. Perfusion of angiotensin II or
adrenocorticotropin for 3 h increased aldosterone and
corticosterone production and decreased deoxycorticosterone, suggesting
that aldosterone and corticosterone are formed within the isolated
heart from a locally present substrate.
-hydroxylase and aldosterone-synthase mRNAs
were independently regulated by 1 week's treatment with either low
sodium and high potassium diet (which increased aldosterone synthase
mRNA level only), angiotensin II (which raised level of both
mRNAs), or adrenocorticotropin (which stimulated the
11-hydroxylase gene exclusively). Changes in cardiac steroid levels
during treatment were not directly related to their plasma levels
suggesting independent regulating mechanisms. This study, therefore,
provides the first evidence for the existence of an endocrine cardiac
steroidogenic system in rat heart and emphasizes its potential
physiological and pathological relevance.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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E. Harada, M. Yoshimura, H. Yasue, O. Nakagawa, M. Nakagawa, M. Harada, Y. Mizuno, M. Nakayama, Y. Shimasaki, T. Ito, et al. Aldosterone Induces Angiotensin-Converting-Enzyme Gene Expression in Cultured Neonatal Rat Cardiocytes Circulation, July 10, 2001; 104(2): 137 - 139. [Abstract] [Full Text] [PDF]
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B. M. W. Schmidt, A. C. Georgens, N. Martin, H.-C. Tillmann, M. Feuring, M. Christ, and M. Wehling Interaction of Rapid Nongenomic Cardiovascular Aldosterone Effects with the Adrenergic System J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 761 - 767. [Abstract] [Full Text]
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A. Fiebeler, F. Schmidt, D. N. Muller, J.-K. Park, R. Dechend, M. Bieringer, E. Shagdarsuren, V. Breu, H. Haller, and F. C. Luft Mineralocorticoid Receptor Affects AP-1 and Nuclear Factor-{{kappa}}B Activation in Angiotensin II-Induced Cardiac Injury Hypertension, February 1, 2001; 37(2): 787 - 793. [Abstract] [Full Text] [PDF]
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Y. Mizuno, M. Yoshimura, H. Yasue, T. Sakamoto, H. Ogawa, K. Kugiyama, E. Harada, M. Nakayama, S. Nakamura, T. Ito, et al. Aldosterone Production Is Activated in Failing Ventricle in Humans Circulation, January 2, 2001; 103(1): 72 - 77. [Abstract] [Full Text] [PDF]
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J. Bauersachs, D. Fraccarollo, G. Ertl, N. Gretz, M. Wehling, and M. Christ Striking Increase of Natriuresis by Low-Dose Spironolactone in Congestive Heart Failure Only in Combination With ACE Inhibition : Mechanistic Evidence to Support RALES Circulation, November 7, 2000; 102(19): 2325 - 2328. [Abstract] [Full Text] [PDF]
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Y. Takeda, T. Yoneda, M. Demura, I. Miyamori, and H. Mabuchi Cardiac Aldosterone Production in Genetically Hypertensive Rats Hypertension, October 1, 2000; 36(4): 495 - 500. [Abstract] [Full Text] [PDF]
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T. Tsutamoto, A. Wada, K. Maeda, N. Mabuchi, M. Hayashi, T. Tsutsui, M. Ohnishi, M. Sawaki, M. Fujii, T. Matsumoto, et al. Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure J. Am. Coll. Cardiol., September 1, 2000; 36(3): 838 - 844. [Abstract] [Full Text] [PDF]
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K. M. Kayes-Wandover and P. C. White Steroidogenic Enzyme Gene Expression in the Human Heart J. Clin. Endocrinol. Metab., July 1, 2000; 85(7): 2519 - 2525. [Abstract] [Full Text]
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M. O. Boluyt and O. H.L. Bing Matrix gene expression and decompensated heart failure: The aged SHR model Cardiovasc Res, May 1, 2000; 46(2): 239 - 249. [Abstract] [Full Text] [PDF]
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J.-P. Benitah and G. Vassort Aldosterone Upregulates Ca2+ Current in Adult Rat Cardiomyocytes Circ. Res., December 3, 1999; 85(12): 1139 - 1145. [Abstract] [Full Text] [PDF]
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A. Hautanen, P. Toivanen, M. Manttari, L. Tenkanen, M. Kupari, V. Manninen, K. M. Kayes, S. Rosenfeld, and P. C. White Joint Effects of an Aldosterone Synthase (CYP11B2) Gene Polymorphism and Classic Risk Factors on Risk of Myocardial Infarction Circulation, November 30, 1999; 100(22): 2213 - 2218. [Abstract] [Full Text] [PDF]
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B. M. W. Schmidt, A. Montealegre, C. P. Janson, N. Martin, C. Stein-Kemmesies, A. Scherhag, M. Feuring, M. Christ, and M. Wehling Short Term Cardiovascular Effects of Aldosterone in Healthy Male Volunteers J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3528 - 3533. [Abstract] [Full Text] [PDF]
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K. T. Weber Aldosterone and Spironolactone in Heart Failure N. Engl. J. Med., September 2, 1999; 341(10): 752 - 755. [Full Text]
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K. C Wollert and H. Drexler The renin-angiotensin system and experimental heart failure Cardiovasc Res, September 1, 1999; 43(4): 838 - 849. [Abstract] [Full Text] [PDF]
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C. Delcayre and J.-S. Silvestre Aldosterone and the heart: towards a physiological function? Cardiovasc Res, July 1, 1999; 43(1): 7 - 12. [Full Text] [PDF]
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J.-S. Silvestre, C. Heymes, A. Oubenaissa, V. Robert, B. Aupetit-Faisant, A. Carayon, B. Swynghedauw, and C. Delcayre Activation of Cardiac Aldosterone Production in Rat Myocardial Infarction : Effect of Angiotensin II Receptor Blockade and Role in Cardiac Fibrosis Circulation, May 25, 1999; 99(20): 2694 - 2701. [Abstract] [Full Text] [PDF]
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 A. G. Mensah-Nyagan, J.-L. Do-Rego, D. Beaujean, V. Luu-The, G. Pelletier, and H. Vaudry Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System Pharmacol. Rev., March 1, 1999; 51(1): 63 - 82. [Abstract] [Full Text] [PDF]
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