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J Biol Chem, Vol. 274, Issue 1, 129-134, January 1, 1999
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From the Dishevelled (Dsh/Dvl) proteins are known to
mediate Wnt signaling by up-regulating Department of Pharmacology and Physiology
and Department of Oncology, University of Rochester, Rochester, New
York 14642-8711, § Shanghai Institute of Biochemistry,
Chinese Academy of Science, Shanghai, People's Republic of China,
Harvard University, Cambridge, Massachusetts 02163, and
** Department of Obstetrics and Gynecology, University of Maryland,
Baltimore, Maryland 21250
-catenin levels and
stimulating T cell factor (TCF)/LEF-1-dependent
transcription. We have identified a new Dvl-mediated signaling pathway
in that mouse Dvl proteins, when expressed in COS-7 cells, stimulate
c-Jun-dependent transcription activity and the kinase
activity of the c-Jun N-terminal kinase (JNK). The DEP domain of Dvl1
is essential for JNK activation. By contrast, all three conserved
domains of Dvl, including DIX, PDZ, and DEP, are required for
up-regulation of -catenin and for stimulation of LEF-1-mediated
transcription in mammalian cells. Thus, Dvl can lead to two different
signaling pathways. Furthermore, the small G proteins of Cdc42 or Rac1,
which are involved in JNK activation by many stimuli, do not appear to
play a major role in Dvl-mediated JNK activation, because the dominant
negative mutants of Cdc42 and Rac1 could not inhibit Dvl-induced JNK
activation. This suggests that Dvl may activate JNK via novel pathways.
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S Naylor, M. Smalley, D Robertson, B. Gusterson, P. Edwards, and T. Dale Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium J. Cell Sci., January 6, 2000; 113(12): 2129 - 2138. [Abstract] [PDF]
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J Behrens Cross-regulation of the Wnt signalling pathway: a role of MAP kinases J. Cell Sci., January 3, 2000; 113(6): 911 - 919. [Abstract] [PDF]
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Y. Zhang, S. Y. Neo, X. Wang, J. Han, and S.-C. Lin Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling J. Biol. Chem., December 3, 1999; 274(49): 35247 - 35254. [Abstract] [Full Text] [PDF]
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E. A. Nillni, R. Steinmetz, and O. H. Pescovitz Posttranslational Processing of Progrowth Hormone-Releasing Hormone Endocrinology, December 1, 1999; 140(12): 5817 - 5827. [Abstract] [Full Text]
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J. C. Baker, R. S.P. Beddington, and R. M. Harland Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development Genes & Dev., December 1, 1999; 13(23): 3149 - 3159. [Abstract] [Full Text]
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H. Yuan, J. Mao, L. Li, and D. Wu Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation J. Biol. Chem., October 22, 1999; 274(43): 30419 - 30423. [Abstract] [Full Text] [PDF]
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T. Moriguchi, K. Kawachi, S. Kamakura, N. Masuyama, H. Yamanaka, K. Matsumoto, A. Kikuchi, and E. Nishida Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates J. Biol. Chem., October 22, 1999; 274(43): 30957 - 30962. [Abstract] [Full Text] [PDF]
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S. Kishida, H. Yamamoto, S.-i. Hino, S. Ikeda, M. Kishida, and A. Kikuchi DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate beta -Catenin Stability Mol. Cell. Biol., June 1, 1999; 19(6): 4414 - 4422. [Abstract] [Full Text] [PDF]
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Y. Zhang, S. Y. Neo, J. Han, and S.-C. Lin Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase J. Biol. Chem., August 4, 2000; 275(32): 25008 - 25014. [Abstract] [Full Text] [PDF]
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A. G. Ridgeway, H. Petropoulos, S. Wilton, and I. S. Skerjanc Wnt Signaling Regulates the Function of MyoD and Myogenin J. Biol. Chem., October 13, 2000; 275(42): 32398 - 32405. [Abstract] [Full Text] [PDF]
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T. Kadoya, S. Kishida, A. Fukui, T. Hinoi, T. Michiue, M. Asashima, and A. Kikuchi Inhibition of Wnt Signaling Pathway by a Novel Axin-binding Protein J. Biol. Chem., November 17, 2000; 275(47): 37030 - 37037. [Abstract] [Full Text] [PDF]
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M. Kishida, S.-i. Hino, T. Michiue, H. Yamamoto, S. Kishida, A. Fukui, M. Asashima, and A. Kikuchi Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iepsilon J. Biol. Chem., August 24, 2001; 276(35): 33147 - 33155. [Abstract] [Full Text] [PDF]
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Y. Cai, M. S. Lechner, D. Nihalani, M. J. Prindle, L. B. Holzman, and G. R. Dressler Phosphorylation of Pax2 by the c-Jun N-terminal Kinase and Enhanced Pax2-dependent Transcription Activation J. Biol. Chem., January 4, 2002; 277(2): 1217 - 1222. [Abstract] [Full Text] [PDF]
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A. Makkinje, D. A. Quinn, A. Chen, C. L. Cadilla, T. Force, J. V. Bonventre, and J. M. Kyriakis Gene 33/Mig-6, a Transcriptionally Inducible Adapter Protein That Binds GTP-Cdc42 and Activates SAPK/JNK. A POTENTIAL MARKER TRANSCRIPT FOR CHRONIC PATHOLOGIC CONDITIONS, SUCH AS DIABETIC NEPHROPATHY. POSSIBLE ROLE IN THE RESPONSE TO PERSISTENT STRESS J. Biol. Chem., June 2, 2000; 275(23): 17838 - 17847. [Abstract] [Full Text] [PDF]
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W. Chen, L. A. Hu, M. V. Semenov, S. Yanagawa, A. Kikuchi, R. J. Lefkowitz, and W. E. Miller beta -Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins PNAS, December 18, 2001; 98(26): 14889 - 14894. [Abstract] [Full Text] [PDF]
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