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J Biol Chem, Vol. 274, Issue 1, 510-515, January 1, 1999
From the The Ah receptor (AhR) mediates many of the toxic
responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs)
which are ubiquitous environmental contaminants causing toxic responses in human and wildlife. NF-
Ah Receptor and NF-
B Interactions, a Potential Mechanism for
Dioxin Toxicity
,,
, and
Department of Environmental and Community
Medicine, Environmental & Occupational Health Sciences Institute,
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson
Medical School, Piscataway, New Jersey 08854, the
§ Department of Environmental Toxicology, University of
California, Davis, California 95616, the ¶ Center for Advanced
Biotechnology and Medicine, Department of Molecular Genetics and
Microbiology, University of Medicine and Dentistry of New Jersey-Robert
Wood Johnson Medical School, Piscataway, New Jersey 08854, and the
Cancer Institute of New Jersey, New Brunswick, New Jersey
08901
B is a pleiotropic transcription factor controlling many physiological functions adversely affected by PAHs,
including immune suppression, thymus involution, hyperkeratosis, and
carcinogenesis. Here, we show physical interaction and mutual functional repression between AhR and NF-B. This mutual repression may provide an underlying mechanism for many hitherto poorly understood PAH-induced toxic responses, and may also provide a mechanistic explanation for alteration of xenobiotic metabolism by cytokines and
compounds that regulate NF-B.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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