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J Biol Chem, Vol. 274, Issue 1, 522-526, January 1, 1999
,,
From the We have found that the novel phospholipid
diacylglycerol pyrophosphate (DGPP), identified in bacteria, yeast, and
plants, but not in mammalian cells, is able to potently activate
macrophages for enhanced secretion of arachidonate metabolites, a key
event in the immunoinflammatory response of leukocytes. Macrophage
responses to DGPP are specific and are not mediated by its conversion
into other putative lipid mediators such as phosphatidic acid,
lysophosphatidic acid, or diacylglycerol. The responses to DGPP are
compatible with a receptor-recognition event because they are blocked
by suramin. Intracellular signaling initiated by DGPP includes
phosphorylation and activation of the Group IV cytosolic phospholipase
A2 and of the extracellular-signal regulated p42
mitogen-activated protein kinase (MAPK) and p44 MAPK, and membrane
translocation of the protein kinase C isoenzymes Department of Chemistry and Biochemistry,
School of Medicine and Revelle College, University of California at
San Diego, La Jolla, California 92093-0601 and the
§ Department of Food Science, Cook College, New Jersey
Agricultural Experimental Station, Rutgers University,
New Brunswick, New Jersey 08901-8520
, 
, 
. These
results establish DGPP as a novel macrophage-activating factor and
suggest a potential role for this compound in triggering homeostatic
cellular responses.
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