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J Biol Chem, Vol. 274, Issue 10, 6056-6061, March 5, 1999
From the Among members of the tumor necrosis factor
receptor (TNFR) superfamily, 4-1BB, CD27, and glucocorticoid-induced
tumor necrosis factor receptor family-related gene (GITR) share a
striking homology in the cytoplasmic domain. Here we report the
identification of a new member, activation-inducible TNFR family member
(AITR), which belongs to this subfamily, and its ligand. The receptor is expressed in lymph node and peripheral blood leukocytes, and its
expression is up-regulated in human peripheral mononuclear cells mainly
after stimulation with anti-CD3/CD28 monoclonal antibodies or phorbol
12-myristate 13-acetate/ionomycin. AITR associates with TRAF1 (TNF
receptor-associated factor 1), TRAF2, and TRAF3, and induces nuclear
factor (NF)-
Identification of a Novel Activation-inducible Protein of the
Tumor Necrosis Factor Receptor Superfamily and Its Ligand
,,,,
Department of Microbiology and Immunology
and the Walther Oncology Center, Indiana University School of Medicine
and the Walther Cancer Institute, Indianapolis, Indiana 46202, § Human Genome Sciences, Rockville, Maryland 20850, and the
Department of Biological Sciences and the
Immunomodulation Research Center, University of Ulsan, Ulsan, Korea
B activation via TRAF2. The ligand for AITR (AITRL) was
found to be an undescribed member of the TNF family, which is expressed
in endothelial cells. Thus, AITR and AITRL seem to be important for
interactions between activated T lymphocytes and endothelial cells.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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