HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Launay, P. Articles by Monteiro, R. C. Search for Related Content PubMed PubMed Citation Articles by Launay, P. Articles by Monteiro, R. C. Social Bookmarking                      What's this?

J Biol Chem, Vol. 274, Issue 11, 7216-7225, March 12, 1999

Alternative Endocytic Pathway for Immunoglobulin A Fc Receptors (CD89) Depends on the Lack of FcR Association and Protects against Degradation of Bound Ligand

Pierre Launay, Claire Patry^§, Agnès Lehuen, Benoit Pasquier, Ulrich Blank^¶, and Renato C. Monteiro

From  INSERM, Unité 25, Hôpital Necker, 75743 Paris, ^§ Unité Mixte de Recherche, Institut Curie/CNRS 144, 75005 Paris, and the ^¶ Unité d'Immunoallergie, Institut Pasteur, 75015 Paris, France

IgA is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum because it is catabolized faster than IgG. IgA exists in monomeric and polymeric forms that function through receptors expressed on effector cells. Here, we show that IgA Fc receptor(s) (FcR) are expressed with or without the  chain on monocytes and neutrophils. -less FcR represent a significant fraction of surface FcR molecules even on cells overexpressing the  chain. The FcR-2 association is up-regulated by phorbol esters and interferon-. To characterize -less FcR functionally, we generated mast cell transfectants expressing wild-type human FcR or a receptor with a point mutation (Arg  Leu at position 209) which was unable to associate with the  chain. Mutant -less FcR bound monomeric and polymeric human IgA1 or IgA2 but failed to induce exocytosis after receptor clustering. The two types of transfectant showed similar kinetics of FcR-mediated endocytosis; however, the endocytosis pathways of the two types of receptor differed. Whereas mutant FcR were localized mainly in early endosomes, those containing FcR-2 were found in endo-lysosomal compartments. Mutant -less FcR recycled the internalized IgA toward the cell surface and protected against IgA degradation. Cells expressing the two forms of FcR, associated or unassociated with  chains, may thus have differential functions either by degrading IgA antibody complexes or by recycling serum IgA.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				K. Qian, F. Xie, A. W. Gibson, J. C. Edberg, R. P. Kimberly, and J. Wu Functional expression of IgA receptor Fc{alpha}RI on human platelets J. Leukoc. Biol., December 1, 2008; 84(6): 1492 - 1500. [Abstract] [Full Text] [PDF]

				J. E. Bakema, A. Bakker, S. de Haij, H. Honing, M. Bracke, L. Koenderman, G. Vidarsson, J. G. J. van de Winkel, and J. H. W. Leusen Inside-Out Regulation of Fc{alpha}RI (CD89) Depends on PP2A J. Immunol., September 15, 2008; 181(6): 4080 - 4088. [Abstract] [Full Text] [PDF]

				M. A. Otten, J. H. W. Leusen, E. Rudolph, J. A. van der Linden, R. H. J. Beelen, J. G. J. van de Winkel, and M. van Egmond FcR {gamma}-Chain Dependent Signaling in Immature Neutrophils Is Mediated by Fc{alpha}RI, but Not by Fc{gamma}RI J. Immunol., September 1, 2007; 179(5): 2918 - 2924. [Abstract] [Full Text] [PDF]

				J. Wu, C. Ji, F. Xie, C. D. Langefeld, K. Qian, A. W. Gibson, J. C. Edberg, and R. P. Kimberly Fc{alpha}RI (CD89) Alleles Determine the Proinflammatory Potential of Serum IgA J. Immunol., March 15, 2007; 178(6): 3973 - 3982. [Abstract] [Full Text] [PDF]

				Y. Kanamaru, H. Tamouza, S. Pfirsch, D. El Mehdi, C. Guerin-Marchand, M. Pretolani, U. Blank, and R. C. Monteiro IgA Fc receptor I signals apoptosis through the FcR{gamma} ITAM and affects tumor growth Blood, January 1, 2007; 109(1): 203 - 211. [Abstract] [Full Text] [PDF]

				J. E. Bakema, S. de Haij, C. F. den Hartog-Jager, J. Bakker, G. Vidarsson, M. van Egmond, J. G. J. van de Winkel, and J. H. W. Leusen Signaling through Mutants of the IgA Receptor CD89 and Consequences for Fc Receptor {gamma}-Chain Interaction J. Immunol., March 15, 2006; 176(6): 3603 - 3610. [Abstract] [Full Text] [PDF]

				M. A. Otten, E. Rudolph, M. Dechant, C. W. Tuk, R. M. Reijmers, R. H. J. Beelen, J. G. J. van de Winkel, and M. van Egmond Immature Neutrophils Mediate Tumor Cell Killing via IgA but Not IgG Fc Receptors J. Immunol., May 1, 2005; 174(9): 5472 - 5480. [Abstract] [Full Text] [PDF]

				H. Qin, J. C. Edberg, A. W. Gibson, G. P. Page, L. Teng, and R. P. Kimberly Differential Gene Expression Modulated by the Cytoplasmic Domain of Fc{gamma}RIa (CD64) {alpha}-Chain J. Immunol., November 15, 2004; 173(10): 6211 - 6219. [Abstract] [Full Text] [PDF]

				B. D. Wines, H. M. Trist, R. C. Monteiro, C. van Kooten, and P. M. Hogarth Fc Receptor {gamma} Chain Residues at the Interface of the Cytoplasmic and Transmembrane Domains Affect Association with Fc{alpha}RI, Surface Expression, and Function J. Biol. Chem., June 18, 2004; 279(25): 26339 - 26345. [Abstract] [Full Text] [PDF]

				R. Reljic, C. Crawford, S. Challacombe, and J. Ivanyi Mouse IgA inhibits cell growth by stimulating tumor necrosis factor-{alpha} production and apoptosis of macrophage cell lines Int. Immunol., April 1, 2004; 16(4): 607 - 614. [Abstract] [Full Text] [PDF]

				M.-K. Kim, Z.-Y. Huang, P.-H. Hwang, B. A. Jones, N. Sato, S. Hunter, T.-H. Kim-Han, R. G. Worth, Z. K. Indik, and A. D. Schreiber Fc{gamma} receptor transmembrane domains: role in cell surface expression, {gamma} chain interaction, and phagocytosis Blood, June 1, 2003; 101(11): 4479 - 4484. [Abstract] [Full Text] [PDF]

				P. J. M. van der Boog, G. van Zandbergen, J. W. de Fijter, N. Klar-Mohamad, A. van Seggelen, P. Brandtzaeg, M. R. Daha, and C. van Kooten Fc{alpha}RI/CD89 Circulates in Human Serum Covalently Linked to IgA in a Polymeric State J. Immunol., February 1, 2002; 168(3): 1252 - 1258. [Abstract] [Full Text] [PDF]

				C. Pilette, Y. Ouadrhiri, V. Godding, J-P. Vaerman, and Y. Sibille Lung mucosal immunity: immunoglobulin-A revisited Eur. Respir. J., September 1, 2001; 18(3): 571 - 588. [Abstract] [Full Text] [PDF]

				M. L. Lang, L. Shen, H. Gao, W. F. Cusack, G. A. Lang, and W. F. Wade Fc{{alpha}} Receptor Cross-Linking Causes Translocation of Phosphatidylinositol-Dependent Protein Kinase 1 and Protein Kinase B{{alpha}} to MHC Class II Peptide-Loading-Like Compartments J. Immunol., May 1, 2001; 166(9): 5585 - 5593. [Abstract] [Full Text] [PDF]

				A. C. Honorio-França, P. Launay, M. M. S. Carneiro-Sampaio, and R. C. Monteiro Colostral neutrophils express Fc{alpha} receptors (CD89) lacking {gamma} chain association and mediate noninflammatory properties of secretory IgA J. Leukoc. Biol., February 1, 2001; 69(2): 289 - 296. [Abstract] [Full Text]

				F. Geissmann, P. Launay, B. Pasquier, Y. Lepelletier, M. Leborgne, A. Lehuen, N. Brousse, and R. C. Monteiro A Subset of Human Dendritic Cells Expresses IgA Fc Receptor (CD89), Which Mediates Internalization and Activation Upon Cross-Linking by IgA Complexes J. Immunol., January 1, 2001; 166(1): 346 - 352. [Abstract] [Full Text] [PDF]

				T. Keler, P. K. Wallace, L. A. Vitale, C. Russoniello, K. Sundarapandiyan, R. F. Graziano, and Y. M. Deo Differential Effect of Cytokine Treatment on Fc{alpha} Receptor I- and Fc{gamma} Receptor I-Mediated Tumor Cytotoxicity by Monocyte-Derived Macrophages J. Immunol., June 1, 2000; 164(11): 5746 - 5752. [Abstract] [Full Text] [PDF]

				P. Launay, B. Grossetete, M. Arcos-Fajardo, E. Gaudin, S. P. Torres, L. Beaudoin, N. Patey-Mariaud de Serre, A. Lehuen, and R. C. Monteiro Fc{alpha} Receptor (CD89) Mediates the Development of Immunoglobulin A (IgA) Nephropathy (Berger's Disease): Evidence for Pathogenic Soluble Receptor-IgA Complexes in Patients and CD89 Transgenic Mice J. Exp. Med., June 6, 1999; 191(11): 1999 - 2010. [Abstract] [Full Text] [PDF]