| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 11, 7341-7350, March 12, 1999
From the The cyclin D1 gene is overexpressed
in breast tumors and encodes a regulatory subunit of
cyclin-dependent kinases that phosphorylate the
retinoblastoma protein. pp60c-src activity is
frequently increased in breast tumors; however, the mechanisms
governing pp60c-src regulation of the cell cycle in
breast epithelium are poorly understood. In these studies,
pp60v-src induced cyclin D1 protein levels and
promoter activity (48-fold) in MCF7 cells. Cyclin D1-associated kinase
activity and protein levels were increased in mammary tumors from
murine mammary tumor virus-pp60c-src527F transgenic mice.
Optimal induction of cyclin D1 by pp60v-src
involved the extracellular signal-regulated kinase, p38, and c-Jun
N-terminal kinase members of the mitogen-activated protein kinase
family. Cyclin D1 promoter activation by pp60v-src
involved a cAMP response element-binding protein (CREB)/activating transcription factor 2 (ATF-2) binding site. Dominant negative mutants
of CREB and ATF-2 but not c-Jun inhibited pp60v-src
induction of cyclin D1. pp60v-src induction of CREB
was blocked by the p38 inhibitor SB203580 or by mutation of CREB at
Ser133. pp60v-src induction of ATF-2
was abolished by the c-Jun N-terminal kinase inhibitor JNK-interacting
protein-1 or by mutation of ATF-2 at Thr69 and
Thr71. CREB and ATF-2, which bind to a common
pp60v-src response element, are transcriptionally
activated by distinct mitogen-activated protein kinases. Induction of
cyclin D1 activity by pp60v-src may contribute to
breast tumorigenesis through phosphorylation and inactivation of the
retinoblastoma protein.
pp60v-src Induction of Cyclin D1 Requires
Collaborative Interactions between the Extracellular
Signal-regulated Kinase, p38, and Jun Kinase Pathways
A ROLE FOR cAMP RESPONSE ELEMENT-BINDING PROTEIN AND ACTIVATING
TRANSCRIPTION FACTOR-2 IN pp60v-src SIGNALING IN
BREAST CANCER CELLS
,,,,
,,,
Departments of Developmental and Molecular
Biology and Medicine, Albert Einstein Cancer Center, Albert Einstein
College of Medicine, Bronx, New York 10461, the
§ Department of Pathology, New York University Medical
Center, New York, NY 10016, the ¶ Department of Pathology,
Northwestern University Medical School, Chicago, Illinois 60611, the
Department of Pathology, McMaster University, West Hamilton,
Ontario L8S 4K1, Canada, the Departments
of Pathology and Cell Biology, Harvard Medical School,
Boston Massachusetts 02115, and the §§ Howard
Hughes Medical Institute and Program in Molecular Medicine, Department
of Biochemistry and Molecular biology, University of Massachusetts
Medical School, Worcester, Massachusetts 01605
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. F. Raven, D. Baltzis, S. Wang, Z. Mounir, A. I. Papadakis, H. Q. Gao, and A. E. Koromilas PKR and PKR-like Endoplasmic Reticulum Kinase Induce the Proteasome-dependent Degradation of Cyclin D1 via a Mechanism Requiring Eukaryotic Initiation Factor 2{alpha} Phosphorylation J. Biol. Chem., February 8, 2008; 283(6): 3097 - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Ansari, Y. M. Sung, G. He, and S. M. Fischer Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin Carcinogenesis, October 1, 2007; 28(10): 2063 - 2068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kikuchi, C. Uchida, T. Hattori, T. Isobe, Y. Hiramatsu, K. Kitagawa, T. Oda, H. Konno, and M. Kitagawa ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells Carcinogenesis, August 1, 2007; 28(8): 1752 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. K. Saxena, P. M. Vertino, F. A. Anania, and D. Sharma Leptin-induced Growth Stimulation of Breast Cancer Cells Involves Recruitment of Histone Acetyltransferases and Mediator Complex to CYCLIN D1 Promoter via Activation of Stat3 J. Biol. Chem., May 4, 2007; 282(18): 13316 - 13325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Casimiro, O. Rodriguez, L. Pootrakul, M. Aventian, N. Lushina, C. Cromelin, G. Ferzli, K. Johnson, S. Fricke, F. Diba, et al. ErbB-2 Induces the Cyclin D1 Gene in Prostate Epithelial Cells In vitro and In vivo Cancer Res., May 1, 2007; 67(9): 4364 - 4372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Ju, S. Katiyar, C. Wang, M. Liu, X. Jiao, S. Li, J. Zhou, J. Turner, M. P. Lisanti, R. G. Russell, et al. Akt1 governs breast cancer progression in vivo PNAS, May 1, 2007; 104(18): 7438 - 7443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Mukhopadhyay, E. A. Sausville, J. H. Doroshow, and K. K. Roy Molecular Mechanism of Adaphostin-mediated G1 Arrest in Prostate Cancer (PC-3) Cells: SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR, c-Met, AND p38 MAPK PATHWAYS J. Biol. Chem., December 8, 2006; 281(49): 37330 - 37344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Cespedes, F. J. Sancho, S. Guerrero, M. Parreno, I. Casanova, M. A. Pavon, E. Marcuello, M. Trias, M. Cascante, G. Capella, et al. K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12 Carcinogenesis, November 1, 2006; 27(11): 2190 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Goormachtigh, T.-S. Ouk, A. Mougel, D. Tranchand-Bunel, E. Masy, C. Le Clorennec, J. Feuillard, G. W. Bornkamm, C. Auriault, E. Manet, et al. Autoactivation of the Epstein-Barr Virus Oncogenic Protein LMP1 during Type II Latency through Opposite Roles of the NF-{kappa}B and JNK Signaling Pathways. J. Virol., August 1, 2006; 80(15): 7382 - 7393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J-R Weng, C-Y Chen, J J Pinzone, M D Ringel, and C-S Chen Beyond peroxisome proliferator-activated receptor {gamma} signaling: the multi-facets of the antitumor effect of thiazolidinediones. Endocr. Relat. Cancer, June 1, 2006; 13(2): 401 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Li, C. Wang, X. Jiao, Y. Lu, M. Fu, A. A. Quong, C. Dye, J. Yang, M. Dai, X. Ju, et al. Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling. Mol. Cell. Biol., June 1, 2006; 26(11): 4240 - 4256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ouyang, J. Li, Q. Ma, and C. Huang Essential roles of PI-3K/Akt/IKK{beta}/NF{kappa}B pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells Carcinogenesis, April 1, 2006; 27(4): 864 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sourisseau, A. Georgiadis, A. Tsapara, R. R. Ali, R. Pestell, K. Matter, and M. S. Balda Regulation of PCNA and Cyclin D1 Expression and Epithelial Morphogenesis by the ZO-1-Regulated Transcription Factor ZONAB/DbpA. Mol. Cell. Biol., March 1, 2006; 26(6): 2387 - 2398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Leslie, C. Lang, G. Devgan, J. Azare, M. Berishaj, W. Gerald, Y. B. Kim, K. Paz, J. E. Darnell, C. Albanese, et al. Cyclin d1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res., March 1, 2006; 66(5): 2544 - 2552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao, D. Chinnappan, R. Pestell, C. Albanese, and H. C. Weber Bombesin Regulates Cyclin D1 Expression through the Early Growth Response Protein Egr-1 in Prostate Cancer Cells Cancer Res., November 1, 2005; 65(21): 9934 - 9942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ouyang, Q. Ma, J. Li, D. Zhang, Z.-g. Liu, A. K. Rustgi, and C. Huang Cyclin D1 Induction through I{kappa}B Kinase {beta}/Nuclear Factor-{kappa}B Pathway Is Responsible for Arsenite-Induced Increased Cell Cycle G1-S Phase Transition in Human Keratinocytes Cancer Res., October 15, 2005; 65(20): 9287 - 9293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Sung, G. He, and S. M. Fischer Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development Cancer Res., October 15, 2005; 65(20): 9304 - 9311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nuntharatanapong, K. Chen, P. Sinhaseni, and J. F. Keaney Jr. EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H99 - H107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Karni, Y. Gus, Y. Dor, O. Meyuhas, and A. Levitzki Active Src Elevates the Expression of {beta}-Catenin by Enhancement of Cap-Dependent Translation Mol. Cell. Biol., June 15, 2005; 25(12): 5031 - 5039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-W. Huang, C.-W. Shiau, Y.-T. Yang, S. K. Kulp, K.-F. Chen, R. W. Brueggemeier, C. L. Shapiro, and C.-S. Chen Peroxisome Proliferator-Activated Receptor {gamma}-Independent Ablation of Cyclin D1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells Mol. Pharmacol., April 1, 2005; 67(4): 1342 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S Lewis, T J Thomas, R. G Pestell, C. Albanese, M. A Gallo, and T. Thomas Differential effects of 16{alpha}-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells J. Mol. Endocrinol., February 1, 2005; 34(1): 91 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fu, C. Wang, Z. Li, T. Sakamaki, and R. G. Pestell Minireview: Cyclin D1: Normal and Abnormal Functions Endocrinology, December 1, 2004; 145(12): 5439 - 5447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Garcia-Silva and A. Aranda The Thyroid Hormone Receptor Is a Suppressor of ras-Mediated Transcription, Proliferation, and Transformation Mol. Cell. Biol., September 1, 2004; 24(17): 7514 - 7523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hulit, C. Wang, Z. Li, C. Albanese, M. Rao, D. Di Vizio, S. Shah, S. W. Byers, R. Mahmood, L. H. Augenlicht, et al. Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice Mol. Cell. Biol., September 1, 2004; 24(17): 7598 - 7611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. See, N. K.M. Rajala, D. G. Spiller, and M. R.H. White Calcium-dependent regulation of the cell cycle via a novel MAPK-NF-{kappa}B pathway in Swiss 3T3 cells J. Cell Biol., August 30, 2004; 166(5): 661 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D'Amico, K. Wu, M. Fu, M. Rao, C. Albanese, R. G. Russell, H. Lian, D. Bregman, M. A. White, and R. G. Pestell The Inhibitor of Cyclin-Dependent Kinase 4a/Alternative Reading Frame (INK4a/ARF) Locus Encoded Proteins p16INK4a and p19ARF Repress Cyclin D1 Transcription through Distinct cis Elements Cancer Res., June 15, 2004; 64(12): 4122 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakayama, M. Kimura, A. Wada, K. Yahiro, K.-i. Ogushi, T. Niidome, A. Fujikawa, D. Shirasaka, N. Aoyama, H. Kurazono, et al. Helicobacter pylori VacA Activates the p38/Activating Transcription Factor 2-mediated Signal Pathway in AZ-521 Cells J. Biol. Chem., February 20, 2004; 279(8): 7024 - 7028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Abramovitch, E. Tavor, J. Jacob-Hirsch, E. Zeira, N. Amariglio, O. Pappo, G. Rechavi, E. Galun, and A. Honigman A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression Cancer Res., February 15, 2004; 64(4): 1338 - 1346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Acosta, R. M. Munoz, L. Gonzalez, A. Subtil-Rodriguez, M. A. Dominguez-Caceres, J. M. Garcia-Martinez, A. Calcabrini, I. Lazaro-Trueba, and J. Martin-Perez Src Mediates Prolactin-Dependent Proliferation of T47D and MCF7 Cells via the Activation of Focal Adhesion Kinase/Erk1/2 and Phosphatidylinositol 3-Kinase Pathways Mol. Endocrinol., November 1, 2003; 17(11): 2268 - 2282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Servitja, M. J. Marinissen, A. Sodhi, X. R. Bustelo, and J. S. Gutkind Rac1 Function Is Required for Src-induced Transformation: EVIDENCE OF A ROLE FOR TIAM1 AND VAV2 IN RAC ACTIVATION BY SRC J. Biol. Chem., September 5, 2003; 278(36): 34339 - 34346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-W. Soh and I. B. Weinstein Roles of Specific Isoforms of Protein Kinase C in the Transcriptional Control of Cyclin D1 and Related Genes J. Biol. Chem., September 5, 2003; 278(36): 34709 - 34716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, N. Pattabiraman, J. N. Zhou, M. Fu, T. Sakamaki, C. Albanese, Z. Li, K. Wu, J. Hulit, P. Neumeister, et al. Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor {gamma} Expression and Transactivation Mol. Cell. Biol., September 1, 2003; 23(17): 6159 - 6173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Fassett, D. Tobolt, C. J. Nelsen, J. H. Albrecht, and L. K. Hansen The Role of Collagen Structure in Mitogen Stimulation of ERK, Cyclin D1 Expression, and G1-S Progression in Rat Hepatocytes J. Biol. Chem., August 22, 2003; 278(34): 31691 - 31700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Brar, Z. Corbin, T. P. Kennedy, R. Hemendinger, L. Thornton, B. Bommarius, R. S. Arnold, A. R. Whorton, A. B. Sturrock, T. P. Huecksteadt, et al. NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells Am J Physiol Cell Physiol, August 1, 2003; 285(2): C353 - C369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D'Amico, K. Wu, D. Di Vizio, A. T. Reutens, M. Stahl, M. Fu, C. Albanese, R. G. Russell, W. J. Muller, M. White, et al. The Role of Ink4a/Arf in ErbB2 Mammary Gland Tumorigenesis Cancer Res., June 15, 2003; 63(12): 3395 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Balasenthil and R. K. Vadlamudi Functional Interactions between the Estrogen Receptor Coactivator PELP1/MNAR and Retinoblastoma Protein J. Biol. Chem., June 6, 2003; 278(24): 22119 - 22127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Kabotyanski and J. M. Rosen Signal Transduction Pathways Regulated by Prolactin and Src Result in Different Conformations of Activated Stat5b J. Biol. Chem., May 2, 2003; 278(19): 17218 - 17227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hecquet, G. Lefevre, M. Valtink, K. Engelmann, and F. Mascarelli Activation and Role of MAP Kinase-Dependent Pathways in Retinal Pigment Epithelium Cells: JNK1, P38 Kinase, and Cell Death Invest. Ophthalmol. Vis. Sci., March 1, 2003; 44(3): 1320 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Boulon, J.-C. Dantonel, V. Binet, A. Vie, J.-M. Blanchard, R. A. Hipskind, and A. Philips Oct-1 Potentiates CREB-Driven Cyclin D1 Promoter Activation via a Phospho-CREB- and CREB Binding Protein-Independent Mechanism Mol. Cell. Biol., November 15, 2002; 22(22): 7769 - 7779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schneider, F. Oswald, C. Wahl, F. R. Greten, G. Adler, and R. M. Schmid Cyclosporine Inhibits Growth through the Activating Transcription Factor/cAMP-responsive Element-binding Protein Binding Site in the Cyclin D1 Promoter J. Biol. Chem., November 8, 2002; 277(46): 43599 - 43607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsui, T. Kinoshita, T. Hirano, T. Yokota, and A. Miyajima STAT3 Down-regulates the Expression of Cyclin D during Liver Development J. Biol. Chem., September 20, 2002; 277(39): 36167 - 36173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. M. Morel, C. C. Park, K. Zhu, P. Kumar, J. H. Ruth, and A. E. Koch Signal Transduction Pathways Involved in Rheumatoid Arthritis Synovial Fibroblast Interleukin-18-induced Vascular Cell Adhesion Molecule-1 Expression J. Biol. Chem., September 13, 2002; 277(38): 34679 - 34691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Page, J. Li, K. C. Corbit, K. M. Rumilla, J.-W. Soh, I. B. Weinstein, C. Albanese, R. G. Pestell, M. R. Rosner, and M. B. Hershenson Regulation of Airway Smooth Muscle Cyclin D1 Transcription by Protein Kinase C-{delta} Am. J. Respir. Cell Mol. Biol., August 1, 2002; 27(2): 204 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dehez, C. Bierkamp, A. Kowalski-Chauvel, L. Daulhac, C. Escrieut, C. Susini, L. Pradayrol, D. Fourmy, and C. Seva c-Jun NH2-terminal Kinase Pathway in Growth-promoting Effect of the G Protein-coupled Receptor Cholecystokinin B Receptor: A Protein Kinase C/Src-dependent-Mechanism Cell Growth Differ., August 1, 2002; 13(8): 375 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Suzui, M. Masuda, J. T. E. Lim, C. Albanese, R. G. Pestell, and I. B. Weinstein Growth Inhibition of Human Hepatoma Cells by Acyclic Retinoid Is Associated with Induction of p21CIP1 and Inhibition of Expression of Cyclin D1 Cancer Res., July 15, 2002; 62(14): 3997 - 4006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wu, C. Wang, M. D'Amico, R. J. Lee, C. Albanese, R. G. Pestell, and S. Mani Flavopiridol and Trastuzumab Synergistically Inhibit Proliferation of Breast Cancer Cells: Association with Selective Cooperative Inhibition of Cyclin D1-dependent Kinase and Akt Signaling Pathways Mol. Cancer Ther., July 1, 2002; 1(9): 695 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-M. Liu, C. Albanese, C. M. Anderson, K. Hilty, P. Webb, R. M. Uht, R. H. Price Jr., R. G. Pestell, and P. J. Kushner Opposing Action of Estrogen Receptors alpha and beta on Cyclin D1 Gene Expression J. Biol. Chem., June 28, 2002; 277(27): 24353 - 24360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Shivakumar, J. Minna, T. Sakamaki, R. Pestell, and M. A. White The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation Mol. Cell. Biol., June 15, 2002; 22(12): 4309 - 4318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Peterson, M. R. Peterson, H. A. Robertson, M. During, and M. Dragunow Selective Down-Regulation of c-jun Gene Expression by Pentoxifylline and c-jun Antisense Interrupts Platelet-Derived Growth Factor Signaling: Pentoxifylline Inhibits Phosphorylation of c-Jun on Serine 73 Mol. Pharmacol., June 1, 2002; 61(6): 1476 - 1488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Brockman, M. D. Schroeder, and L. A. Schuler PRL Activates the Cyclin D1 Promoter Via the Jak2/Stat Pathway Mol. Endocrinol., April 1, 2002; 16(4): 774 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Wooten, M. L. Vandenplas, M. L. Seibenhener, T. Geetha, and M. T. Diaz-Meco Nerve Growth Factor Stimulates Multisite Tyrosine Phosphorylation and Activation of the Atypical Protein Kinase C's via a src Kinase Pathway Mol. Cell. Biol., December 15, 2001; 21(24): 8414 - 8427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 |
