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J Biol Chem, Vol. 274, Issue 12, 7623-7626, March 19, 1999

COMMUNICATION
The B Subunit of the CAAT-binding Factor NFY Binds the Central Segment of the Co-activator p300

Maria Concetta Faniello, Maria Assunta Bevilacqua, GianLuigi Condorelli, Benoit de Crombrugghe, Sankar N. Maity, Vittorio Enrico Avvedimento, Filiberto Cimino, and Francesco Costanzo

From the  Dipartimento di Biochimica e Biotecnologie Mediche, Università degli Studi di Napoli `Federico II', Via S. Pansini 5, I-80131 Napoli, Italy and the  Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Catanzaro, Via T. Campanella, I-88100 Catanzaro, Italy

We report that the heterotrimeric transcription factor NFY or "CAAT-binding factor" binds the 60 region of the human H ferritin promoter, the B site. DNA binding analysis with specific antibodies demonstrates that NFY/B/C subunits tightly bind this site and that NFY/C subunit is masked in vivo by binding with other protein(s). NFY binds the co-activator p300. Specifically, the NFY/B subunit interacts with the central segment of p300 in vivo and in vitro. cAMP substantially increases the formation of the NFY·p300 complex. Taken together these data provide a general model of cAMP induction of non-CRE-containing promoters and suggest that the NFY-B·p300 complex is located at the 5' end of the promoter and the NFY-B·C·TFIIB on the 3' end toward the transcription start site.

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Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.

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