| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 12, 7724-7731, March 19, 1999
From the Various members of the tumor necrosis factor
(TNF) receptor superfamily activate nuclear factor
Activation of NF-
B by RANK Requires Tumor Necrosis Factor
Receptor-associated Factor (TRAF) 6 and NF-B-inducing Kinase
IDENTIFICATION OF A NOVEL TRAF6 INTERACTION MOTIF
,
Cytokine Research Laboratory,
Department of Molecular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 and § Human
Genome Sciences, Inc., Rockville, Maryland 20850
B (NF-B) and
the c-Jun N-terminal kinase (JNK) pathways through their interaction
with TNF receptor-associated factors (TRAFs) and NF-B-inducing
kinase (NIK). We have previously shown that the cytoplasmic domain of
receptor activator of NF-B (RANK) interacts with TRAF2, TRAF5, and
TRAF6 and that its overexpression activates NF-B and JNK pathways.
Through a detailed mutational analysis of the cytoplasmic domain of
RANK, we demonstrate that TRAF2 and TRAF5 bind to consensus TRAF
binding motifs located in the C terminus at positions 565-568 and
606-611, respectively. In contrast, TRAF6 interacts with a novel motif
located between residues 340 and 358 of RANK. Furthermore, transfection
experiments with RANK and its deletion mutants in human embryonic 293 cells revealed that the TRAF6-binding region (340-358), but not the TRAF2 or TRAF5-binding region, is necessary and sufficient for RANK-induced NF-B activation. Moreover, a kinase mutant of NIK (NIK-KM) inhibited RANK-induced NF-B activation. However,
RANK-mediated JNK activation required a distal portion (427-603) of
RANK containing the TRAF2-binding domain. Thus, our results indicate
that RANK interacts with various TRAFs through distinct motifs and
activates NF-B via a novel TRAF6 interaction motif, which then
activates NIK, thus leading to NF-B activation, whereas RANK most
likely activates JNK through a TRAF2-interacting region in RANK.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. N. Somayaji, S. Ritchie, M. Sahraei, I. Marriott, and M. C. Hudson Staphylococcus aureus Induces Expression of Receptor Activator of NF-{kappa}B Ligand and Prostaglandin E2 in Infected Murine Osteoblasts Infect. Immun., November 1, 2008; 76(11): 5120 - 5126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Kunnumakkara, H. Ichikawa, P. Anand, C. J. Mohankumar, P. S. Hema, M. S. Nair, and B. B. Aggarwal Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-{kappa}B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis Mol. Cancer Ther., October 1, 2008; 7(10): 3306 - 3317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lamothe, A. D. Campos, W. K. Webster, A. Gopinathan, L. Hur, and B. G. Darnay The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL J. Biol. Chem., September 5, 2008; 283(36): 24871 - 24880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.E. Wise and G.J. King Mechanisms of Tooth Eruption and Orthodontic Tooth Movement J. Dent. Res., May 1, 2008; 87(5): 414 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Mahlknecht, I. Dichamp, A. Varin, C. Van Lint, and G. Herbein NF-{kappa}B-dependent control of HIV-1 transcription by the second coding exon of Tat in T cells J. Leukoc. Biol., March 1, 2008; 83(3): 718 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Macedo, G. Pinhal-Enfield, V. Alshits, G. Elson, B. N. Cronstein, and S. J. Leibovich Wound Healing Is Impaired in MyD88-Deficient Mice: A Role for MyD88 in the Regulation of Wound Healing by Adenosine A2A Receptors Am. J. Pathol., December 1, 2007; 171(6): 1774 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Pandey, B. Sung, K. S. Ahn, A. B. Kunnumakkara, M. M. Chaturvedi, and B. B. Aggarwal Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-{kappa}B signaling pathway Blood, November 15, 2007; 110(10): 3517 - 3525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Izawa, N. Ishimaru, K. Moriyama, M. Kohashi, R. Arakaki, and Y. Hayashi Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance Blood, July 1, 2007; 110(1): 242 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Pandey, S. K. Sandur, B. Sung, G. Sethi, A. B. Kunnumakkara, and B. B. Aggarwal Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-{kappa}B and NF-{kappa}B-regulated Gene Expression through Direct Inhibition of I{kappa}B{alpha} Kinase beta on Cysteine 179 Residue J. Biol. Chem., June 15, 2007; 282(24): 17340 - 17350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Kunnumakkara, A. S. Nair, K. S. Ahn, M. K. Pandey, Z. Yi, M. Liu, and B. B. Aggarwal Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-{kappa}B activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis Blood, June 15, 2007; 109(12): 5112 - 5121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lamothe, A. Besse, A. D. Campos, W. K. Webster, H. Wu, and B. G. Darnay Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of I{kappa}B Kinase Activation J. Biol. Chem., February 9, 2007; 282(6): 4102 - 4112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Besse, B. Lamothe, A. D. Campos, W. K. Webster, U. Maddineni, S.-C. Lin, H. Wu, and B. G. Darnay TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3 J. Biol. Chem., February 9, 2007; 282(6): 3918 - 3928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Nair, S. Shishodia, K. S. Ahn, A. B. Kunnumakkara, G. Sethi, and B. B. Aggarwal Deguelin, an Akt Inhibitor, Suppresses I{kappa}B{alpha} Kinase Activation Leading to Suppression of NF-{kappa}B-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion J. Immunol., October 15, 2006; 177(8): 5612 - 5622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ichikawa, Y. Takada, S. Shishodia, B. Jayaprakasam, M. G. Nair, and B. B. Aggarwal Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-{kappa}B (NF-{kappa}B) activation and NF-{kappa}B-regulated gene expression. Mol. Cancer Ther., June 1, 2006; 5(6): 1434 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ichikawa, A. Murakami, and B. B. Aggarwal 1'-Acetoxychavicol Acetate Inhibits RANKL-Induced Osteoclastic Differentiation of RAW 264.7 Monocytic Cells by Suppressing Nuclear Factor-{kappa}B Activation Mol. Cancer Res., April 1, 2006; 4(4): 275 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xu, S. Wang, W. Liu, J. Liu, and X. Feng A Novel Receptor Activator of NF-{kappa}B (RANK) Cytoplasmic Motif Plays an Essential Role in Osteoclastogenesis by Committing Macrophages to the Osteoclast Lineage J. Biol. Chem., February 24, 2006; 281(8): 4678 - 4690. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rogers and R. Eastell Circulating Osteoprotegerin and Receptor Activator for Nuclear Factor {kappa}B Ligand: Clinical Utility in Metabolic Bone Disease Assessment J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6323 - 6331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-K. Min, Y.-M. Kim, S. W. Kim, M.-C. Kwon, Y.-Y. Kong, I. K. Hwang, M. H. Won, J. Rho, and Y.-G. Kwon TNF-Related Activation-Induced Cytokine Enhances Leukocyte Adhesiveness: Induction of ICAM-1 and VCAM-1 via TNF Receptor-Associated Factor and Protein Kinase C-Dependent NF-{kappa}B Activation in Endothelial Cells J. Immunol., July 1, 2005; 175(1): 531 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ichikawa, Y. Takada, A. Murakami, and B. B. Aggarwal Identification of a Novel Blocker of I{kappa}B{alpha} Kinase That Enhances Cellular Apoptosis and Inhibits Cellular Invasion through Suppression of NF-{kappa}B-Regulated Gene Products J. Immunol., June 1, 2005; 174(11): 7383 - 7392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Liu, D. Xu, H. Yang, H. Xu, Z. Shi, X. Cao, S. Takeshita, J. Liu, M. Teale, and X. Feng Functional Identification of Three Receptor Activator of NF-{kappa}B Cytoplasmic Motifs Mediating Osteoclast Differentiation and Function J. Biol. Chem., December 24, 2004; 279(52): 54759 - 54769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takada and B. B. Aggarwal Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling Blood, December 15, 2004; 104(13): 4113 - 4121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Aggarwal, Y. Takada, A. M. Mhashilkar, K. Sieger, S. Chada, and B. B. Aggarwal Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-{kappa}B Activation and Suppresses Apoptosis Induced by TNF J. Immunol., October 1, 2004; 173(7): 4368 - 4376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sarkar, Y. Sreenivasan, G. T. Ramesh, and S. K. Manna {beta}-D-Glucoside Suppresses Tumor Necrosis Factor-induced Activation of Nuclear Transcription Factor {kappa}B but Potentiates Apoptosis J. Biol. Chem., August 6, 2004; 279(32): 33768 - 33781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Doherty, L. A. Fitzpatrick, D. Inoue, J.-H. Qiao, M. C. Fishbein, R. C. Detrano, P. K. Shah, and T. B. Rajavashisth Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification Endocr. Rev., August 1, 2004; 25(4): 629 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Bharti, Y. Takada, and B. B. Aggarwal Curcumin (Diferuloylmethane) Inhibits Receptor Activator of NF-{kappa}B Ligand-Induced NF-{kappa}B Activation in Osteoclast Precursors and Suppresses Osteoclastogenesis J. Immunol., May 15, 2004; 172(10): 5940 - 5947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Gentry, N. J. Rutkoski, T. L. Burke, and B. D. Carter A Functional Interaction between the p75 Neurotrophin Receptor Interacting Factors, TRAF6 and NRIF J. Biol. Chem., April 16, 2004; 279(16): 16646 - 16656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hirotani, N. A. Tuohy, J.-T. Woo, P. H. Stern, and N. A. Clipstone The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells J. Biol. Chem., April 2, 2004; 279(14): 13984 - 13992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yu and B. C. Kone The STAT3 DNA-Binding Domain Mediates Interaction with NF-{kappa}B p65 and Inducible Nitric Oxide Synthase Transrepression in Mesangial Cells J. Am. Soc. Nephrol., March 1, 2004; 15(3): 585 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Bharti, Y. Takada, S. Shishodia, and B. B. Aggarwal Evidence That Receptor Activator of Nuclear Factor (NF)-{kappa}B Ligand Can Suppress Cell Proliferation and Induce Apoptosis through Activation of a NF-{kappa}B-independent and TRAF6-dependent Mechanism J. Biol. Chem., February 13, 2004; 279(7): 6065 - 6076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Chiffoleau, T. Kobayashi, M. C. Walsh, C. G. King, P. T. Walsh, W. W. Hancock, Y. Choi, and L. A. Turka TNF Receptor-Associated Factor 6 Deficiency during Hemopoiesis Induces Th2-Polarized Inflammatory Disease J. Immunol., December 1, 2003; 171(11): 5751 - 5759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, E. Jimi, and A. L. M. Bothwell Receptor Activator of NF-{kappa}B Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis J. Immunol., October 1, 2003; 171(7): 3620 - 3626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Polek, M. Talpaz, B. G. Darnay, and T. Spivak-Kroizman TWEAK Mediates Signal Transduction and Differentiation of RAW264.7 Cells in the Absence of Fn14/TweakR: EVIDENCE FOR A SECOND TWEAK RECEPTOR J. Biol. Chem., August 22, 2003; 278(34): 32317 - 32323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Komarova, M. F. Pilkington, A. F. Weidema, S. J. Dixon, and S. M. Sims RANK Ligand-induced Elevation of Cytosolic Ca2+ Accelerates Nuclear Translocation of Nuclear Factor kappa B in Osteoclasts J. Biol. Chem., February 28, 2003; 278(10): 8286 - 8293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Varin, S. K. Manna, V. Quivy, A.-Z. Decrion, C. Van Lint, G. Herbein, and B. B. Aggarwal Exogenous Nef Protein Activates NF-kappa B, AP-1, and c-Jun N-Terminal Kinase and Stimulates HIV Transcription in Promonocytic Cells. ROLE IN AIDS PATHOGENESIS J. Biol. Chem., January 17, 2003; 278(4): 2219 - 2227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ashikawa, S. Majumdar, S. Banerjee, A. C. Bharti, S. Shishodia, and B. B. Aggarwal Piceatannol Inhibits TNF-Induced NF-{kappa}B Activation and NF-{kappa}B-Mediated Gene Expression Through Suppression of I{kappa}B{alpha} Kinase and p65 Phosphorylation J. Immunol., December 1, 2002; 169(11): 6490 - 6497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hotokezaka, E. Sakai, K. Kanaoka, K. Saito, K.-i. Matsuo, H. Kitaura, N. Yoshida, and K. Nakayama U0126 and PD98059, Specific Inhibitors of MEK, Accelerate Differentiation of RAW264.7 Cells into Osteoclast-like Cells J. Biol. Chem., November 27, 2002; 277(49): 47366 - 47372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Armstrong, M. E. Tometsko, M. Glaccum, C. L. Sutherland, D. Cosman, and W. C. Dougall A RANK/TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function J. Biol. Chem., November 8, 2002; 277(46): 44347 - 44356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zhang and B. C. Kone NF-kappa B inhibits transcription of the H+-K+-ATPase alpha 2-subunit gene: role of histone deacetylases Am J Physiol Renal Physiol, November 1, 2002; 283(5): F904 - F911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Anto, A. Mukhopadhyay, S. Shishodia, C. G. Gairola, and B. B. Aggarwal Cigarette smoke condensate activates nuclear transcription factor-{kappa}B through phosphorylation and degradation of I{kappa}B{alpha}: correlation with induction of cyclooxygenase-2 Carcinogenesis, September 1, 2002; 23(9): 1511 - 1518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hull, G. McLean, F. Wong, P. J. Duriez, and A. Karsan Lipopolysaccharide Signals an Endothelial Apoptosis Pathway Through TNF Receptor-Associated Factor 6-Mediated Activation of c-Jun NH2-Terminal Kinase J. Immunol., September 1, 2002; 169(5): 2611 - 2618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Li, N. Udagawa, K. Itoh, K. Suda, Y. Murase, T. Nishihara, T. Suda, and N. Takahashi p38 MAPK-Mediated Signals Are Required for Inducing Osteoclast Differentiation But Not for Osteoclast Function Endocrinology, August 1, 2002; 143(8): 3105 - 3113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yu, W. Zhang, and B. C. Kone Histone Deacetylases Augment Cytokine Induction of the iNOS Gene J. Am. Soc. Nephrol., August 1, 2002; 13(8): 2009 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Majumdar, B. Lamothe, and B. B. Aggarwal Thalidomide Suppresses NF-{kappa}B Activation Induced by TNF and H2O2, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester J. Immunol., March 15, 2002; 168(6): 2644 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Shin, I. Kim, J. S. Lee, G. Y. Koh, Z. H. Lee, and H.-H. Kim A Novel Zinc Finger Protein That Inhibits Osteoclastogenesis and the Function of Tumor Necrosis Factor Receptor-associated Factor 6 J. Biol. Chem., March 1, 2002; 277(10): 8346 - 8353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mizukami, G. Takaesu, H. Akatsuka, H. Sakurai, J. Ninomiya-Tsuji, K. Matsumoto, and N. Sakurai Receptor Activator of NF-{kappa}B Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6 Mol. Cell. Biol., February 15, 2002; 22(4): 992 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. Chung, Y. C. Park, H. Ye, and H. Wu All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction J. Cell Sci., February 15, 2002; 115(4): 679 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fiumara, V. Snell, Y. Li, A. Mukhopadhyay, M. Younes, A. M. Gillenwater, F. Cabanillas, B. B. Aggarwal, and A. Younes Functional expression of receptor activator of nuclear factor kappa B in Hodgkin disease cell lines Blood, November 1, 2001; 98(9): 2784 - 2790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Huber, A. C. Bendixen, P. Pathrose, S. Srivastava, K. M. Dienger, N. K. Shevde, and J. W. Pike Androgens Suppress Osteoclast Formation Induced by RANKL and Macrophage-Colony Stimulating Factor Endocrinology, September 1, 2001; 142(9): 3800 - 3808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Majumdar and B. B. Aggarwal Methotrexate Suppresses NF-{kappa}B Activation Through Inhibition of I{kappa}B{alpha} Phosphorylation and Degradation J. Immunol., September 1, 2001; 167(5): 2911 - 2920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Desreumaux, L. Dubuquoy, S. Nutten, M. Peuchmaur, W. Englaro, K. Schoonjans, B. Derijard, B. Desvergne, W. Wahli, P. Chambon, et al. Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (RXR)/Peroxisome Proliferator-activated Receptor {{gamma}} (PPAR{{gamma}}) Heterodimer: A Basis for New Therapeutic Strategies J. Exp. Med., April 2, 2001; 193(7): 827 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Manna, A. Mukhopadhyay, and B. B. Aggarwal Leflunomide Suppresses TNF-Induced Cellular Responses: Effects on NF-{kappa}B, Activator Protein-1, c-Jun N-Terminal Protein Kinase, and Apoptosis J. Immunol., November 15, 2000; 165(10): 5962 - 5969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Manna, A. Mukhopadhyay, and B. B. Aggarwal IFN-{alpha} Suppresses Activation of Nuclear Transcription Factors NF-{kappa}B and Activator Protein 1 and Potentiates TNF-Induced Apoptosis J. Immunol., November 1, 2000; 165(9): 4927 - 4934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kaneda, T. Nojima, M. Nakagawa, A. Ogasawara, H. Kaneko, T. Sato, H. Mano, M. Kumegawa, and Y. Hakeda Endogenous Production of TGF-{beta} Is Essential for Osteoclastogenesis Induced by a Combination of Receptor Activator of NF-{kappa}B Ligand and Macrophage-Colony- Stimulating Factor J. Immunol., October 15, 2000; 165(8): 4254 - 4263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Kornbluth The emerging role of CD40 ligand in HIV infection J. Leukoc. Biol., |
