| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 12, 7793-7802, March 19, 1999
From the Department of Molecular and Cellular Biology, Roswell Park
Cancer Institute, Buffalo, New York 14263 and the
§ Oncology Gene Therapy Program, The Toronto Hospital,
Toronto, Ontario M5G 2M1, Canada
Interleukin (IL)-6 is a major regulator of
hepatic acute-phase plasma protein (APP) genes. The membrane-proximal
133-amino acid cytoplasmic domain of glycoprotein (gp) 130, containing
one copy of the Box3 motif, is sufficient to transmit a productive signal to endogenous APP genes in rat hepatoma H-35 cells. In contrast,
a mutant gp130 domain lacking the Box3 motif activates Janus kinases to
a normal level but fails to activate signal transducer and activator of
transcription 3 and to up-regulate a number of APP genes, including
thiostatin, fibrinogen, hemopexin, and haptoglobin. However, in the
absence of Box3, gp130 still stimulates the expression of
2-macroglobulin and synergizes with IL-1 to
up-regulate 1-acid glycoprotein. The Box3 motif is not
required for activation of the SH2-containing protein tyrosine
phosphatase 2 or the mitogen-activated protein kinase (MAPK), nor is
the immediate induction of egr-1 and junB
significantly altered. Surprisingly, gp130 without any functional Box3
stimulates prolonged activation of MAPK, leading to an extended period
of up-regulation of egr-1 and to an extracellularly regulated kinase-mediated reduction in the IL-6-stimulated production of thiostatin. IL-6 reduces proliferation of H-35 cells through signaling by the Box3. In addition, cells expressing Box3-deficient gp130 showed distinct morphologic changes upon receptor activation. Taken together, these results indicate that Box3-derived and
Box3-independent signals cooperate in the control of hepatic APP genes
and that Box3 may be involved in the modulation of MAPK activity in
gp130 signaling.
This article has been cited by other articles:
|
|
 |
|
  S. Chattopadhyay, E. Tracy, P. Liang, O. Robledo, S. Rose-John, and H. Baumann Interleukin-31 and Oncostatin-M Mediate Distinct Signaling Reactions and Response Patterns in Lung Epithelial Cells J. Biol. Chem., February 2, 2007; 282(5): 3014 - 3026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Baumann, P. Kunapuli, E. Tracy, and J. K. Cowell The Oncogenic Fusion Protein-tyrosine Kinase ZNF198/Fibroblast Growth Factor Receptor-1 Has Signaling Function Comparable with Interleukin-6 Cytokine Receptors J. Biol. Chem., April 25, 2003; 278(18): 16198 - 16208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.A. Cork, E.M. Tuckerman, T.C. Li, and S.M. Laird Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro Mol. Hum. Reprod., September 1, 2002; 8(9): 841 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Blanchard, Y. Wang, E. Kinzie, L. Duplomb, A. Godard, and H. Baumann Oncostatin M Regulates the Synthesis and Turnover of gp130, Leukemia Inhibitory Factor Receptor alpha , and Oncostatin M Receptor beta by Distinct Mechanisms J. Biol. Chem., December 7, 2001; 276(50): 47038 - 47045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Metzger, T. Hassin, V. Barash, O. Pappo, and T. Chajek-Shaul Reduced body fat and increased hepatic lipid synthesis in mice bearing interleukin-6-secreting tumor Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E957 - E965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ernst, M. Inglese, P. Waring, I. K. Campbell, S. Bao, F. J. Clay, W. S. Alexander, I. P. Wicks, D. M. Tarlinton, U. Novak, et al. Defective gp130-mediated Signal Transducer and Activator of Transcription (STAT) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation J. Exp. Med., July 16, 2001; 194(2): 189 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Alonzi, D. Maritano, B. Gorgoni, G. Rizzuto, C. Libert, and V. Poli Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver Mol. Cell. Biol., March 1, 2001; 21(5): 1621 - 1632. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Y. Wu and R. A. Bradshaw Activation of the Stat3 Signaling Pathway Is Required for Differentiation by Interleukin-6 in PC12-E2 Cells J. Biol. Chem., January 21, 2000; 275(3): 2147 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kim and H. Baumann Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells Mol. Cell. Biol., August 1, 1999; 19(8): 5326 - 5338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, O. Robledo, E. Kinzie, F. Blanchard, C. Richards, A. Miyajima, and H. Baumann Receptor Subunit-specific Action of Oncostatin M in Hepatic Cells and Its Modulation by Leukemia Inhibitory Factor J. Biol. Chem., August 11, 2000; 275(33): 25273 - 25285. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
