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J Biol Chem, Vol. 274, Issue 14, 9686-9691, April 2, 1999

Interferon Consensus Sequence-binding Protein Is Constitutively Expressed and Differentially Regulated in the Ocular Lens

Wenmei LiDagger , Chandrasekharam N. NagineniDagger , Hong Ge§, Bassey Efiok, Ana B. Chepelinsky§, and Charles E. EgwuaguDagger

From the Laboratories of Dagger  Immunology and § Molecular & Developmental Biology, NEI and the  Laboratory of Molecular Hematology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892

Interferon signaling is mediated by STATs and interferon regulatory factor (IRF) families of transcription factors. Ten distinct IRFs have been described and most are expressed in a variety of cells except for interferon consensus sequence-binding protein (ICSBP) and lymphoid-specific IRF/Pip that are thought to be exclusively expressed in lymphoid cells. We show here for the first time that ICSBP is constitutively and inducibly expressed in the mouse lens. In contrast to lymphoid cells with exclusive expression of ICSBP in the nucleus, ICSBP is present in both the cytoplasm and nucleus of the lens cell. However, ICSBP in the nucleus is of lower apparent molecular weight. We further show that the ICSBP promoter is constitutively bound by lens nuclear factors and that its activation requires binding of additional factors including STAT1. Furthermore, transcriptional activation of ICSBP gene by interferon gamma  is accompanied by selective nuclear localization of ICSBP in proliferating epithelial cells but not in the nuclei of nondividing cells in the lens fiber compartment. Constitutive and inducible expression of ICSBP in the ocular lens and differential regulation of its subcellular localization in the developing lens suggest that ICSBP may have nonimmunity related functions and that the commonly held view that it is lymphoid-specific be modified.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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