| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 16, 10689-10692, April 16, 1999
,,
, and
From the Division of TLR4 is a member of the recently identified
Toll-like receptor family of proteins and has been putatively
identified as Lps, the gene necessary for potent responses
to lipopolysaccharide in mammals. In order to determine whether TLR4 is
involved in lipopolysaccharide-induced activation of the nuclear
factor- Inflammatory Diseases and
Synthetic Chemistry, Eisai Research Institute, Andover,
Massachusetts 01810 and the ¶ Boston University School of
Medicine, Boston Medical Center, The Maxwell Finland Laboratory for
Infectious Diseases, Boston, Massachusetts 02118
B (NF-B) pathway, HEK 293 cells were transiently
transfected with human TLR4 cDNA and an
NF-B-dependent luciferase reporter plasmid followed by
stimulation with lipopolysaccharide/CD14 complexes. The results
demonstrate that lipopolysaccharide stimulates NF-B-mediated gene
expression in cells transfected with the TLR4 gene in a dose- and
time-dependent fashion. Furthermore, E5531, a
lipopolysaccharide antagonist, blocked TLR4-mediated transgene
activation in a dose-dependent manner (IC50
~30 nM). These data demonstrate that TLR4 is involved in
lipopolysaccharide signaling and serves as a cell-surface co-receptor for CD14, leading to lipopolysaccharide-mediated NF-B activation and
subsequent cellular events.
This article has been cited by other articles:
|
|
 |
|
  C.-S. Lin, J. G. Wann, C.-W. Hsiao, D. W. Tai, J.-S. Chen, Y.-H. Hsu, H.-C. Huang, and C.-F. Chao Intracellular acidification enhances neutrophil phagocytosis in chronic haemodialysis patients: possible role of CD11b/CD18 Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1642 - 1649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Jain, A. Halle, K. A. Halmen, E. Lien, M. Charrel-Dennis, S. Ram, D. T. Golenbock, and A. Visintin Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative bacteria depend on TLR4 signaling Blood, May 1, 2008; 111(9): 4637 - 4645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Waldo, Y. Li, C. Buono, B. Zhao, E. M. Billings, J. Chang, and H. S. Kruth Heterogeneity of Human Macrophages in Culture and in Atherosclerotic Plaques Am. J. Pathol., April 1, 2008; 172(4): 1112 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Lee, C.-L. Wu, and A.-L. Shiau Toll-like Receptor 4 Mediates an Antitumor Host Response Induced by Salmonella choleraesuis Clin. Cancer Res., March 15, 2008; 14(6): 1905 - 1912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ueno, T. Koga, K. Kato, D. T. Golenbock, S. J. Gendler, H. Kai, and K. C. Kim MUC1 Mucin Is a Negative Regulator of Toll-Like Receptor Signaling Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 263 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Rallabhandi, A. Awomoyi, K. E. Thomas, A. Phalipon, Y. Fujimoto, K. Fukase, S. Kusumoto, N. Qureshi, M. B. Sztein, and S. N. Vogel Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling J. Immunol., January 15, 2008; 180(2): 1139 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Dunn-Siegrist, O. Leger, B. Daubeuf, Y. Poitevin, F. Depis, S. Herren, M. Kosco-Vilbois, Y. Dean, J. Pugin, and G. Elson Pivotal Involvement of Fc{gamma} Receptor IIA in the Neutralization of Lipopolysaccharide Signaling via a Potent Novel Anti-TLR4 Monoclonal Antibody 15C1 J. Biol. Chem., November 30, 2007; 282(48): 34817 - 34827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Morefield, L. D. Hawkins, S. T. Ishizaka, T. L. Kissner, and R. G. Ulrich Synthetic Toll-Like Receptor 4 Agonist Enhances Vaccine Efficacy in an Experimental Model of Toxic Shock Syndrome Clin. Vaccine Immunol., November 1, 2007; 14(11): 1499 - 1504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ostrowska, E. Sokolova, and G. Reiser PAR-2 activation and LPS synergistically enhance inflammatory signaling in airway epithelial cells by raising PAR expression level and interleukin-8 release Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1208 - L1218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Huang, W. Du, R. P. Barrett, and L. D. Hazlett ST2 Is Essential for Th2 Responsiveness and Resistance to Pseudomonas aeruginosa Keratitis Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4626 - 4633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Young Goo, Y. S. Han, W. H. Kim, K.-H. Lee, and S.-J. Park Vibrio vulnificus IlpA-induced Cytokine Production Is Mediated by Toll-like Receptor 2 J. Biol. Chem., September 21, 2007; 282(38): 27647 - 27658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. MacLeod and L. M. Wetzler T Cell Activation by TLRs: A Role for TLRs in the Adaptive Immune Response Sci. Signal., September 4, 2007; 2007(402): pe48 - pe48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Lohmann, M. L. Vandenplas, M. H. Barton, C. E. Bryant, and J. N. Moore The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist Innate Immunity, August 1, 2007; 13(4): 235 - 242. [Abstract] [PDF]
|
|
|
|
 |
|
 S. M Zimmer, S. M Zughaier, Y.-L. Tzeng, and D. S Stephens Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4 Glycobiology, August 1, 2007; 17(8): 847 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Wang, I. O. Akinci, C. M. Baker, D. Urich, A. Bellmeyer, M. Jain, N. S. Chandel, G. M. Mutlu, and G. R. S. Budinger The Intrinsic Apoptotic Pathway Is Required for Lipopolysaccharide-Induced Lung Endothelial Cell Death J. Immunol., August 1, 2007; 179(3): 1834 - 1841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Gafencu, M. R. Robciuc, E. Fuior, V. I. Zannis, D. Kardassis, and M. Simionescu Inflammatory Signaling Pathways Regulating ApoE Gene Expression in Macrophages J. Biol. Chem., July 27, 2007; 282(30): 21776 - 21785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zanin-Zhorov, G. Tal-Lapidot, L. Cahalon, M. Cohen-Sfady, M. Pevsner-Fischer, O. Lider, and I. R. Cohen Cutting Edge: T Cells Respond to Lipopolysaccharide Innately via TLR4 Signaling J. Immunol., July 1, 2007; 179(1): 41 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. B. McCall, M. G. Netea, C. C. Hermsen, T. Jansen, L. Jacobs, D. Golenbock, A. J. A. M. van der Ven, and R. W. Sauerwein Plasmodium falciparum Infection Causes Proinflammatory Priming of Human TLR Responses J. Immunol., July 1, 2007; 179(1): 162 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O.-L. Brekke, D. Christiansen, H. Fure, M. Fung, and T. E. Mollnes The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human whole blood J. Leukoc. Biol., June 1, 2007; 81(6): 1404 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Flynn, B. K. McFarlin, and M. M. Markofski State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training American Journal of Lifestyle Medicine, May 1, 2007; 1(3): 220 - 235. [Abstract] [PDF]
|
|
|
|
 |
|
 M. W. Laschke, M. D. Menger, Y. Wang, G. Lindell, B. Jeppsson, and H. Thorlacius Sepsis-associated cholestasis is critically dependent on P-selectin-dependent leukocyte recruitment in mice Am J Physiol Gastrointest Liver Physiol, May 1, 2007; 292(5): G1396 - G1402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Droemann, J. Rupp, T. Goldmann, U. Uhlig, D. Branscheid, E. Vollmer, P. Kujath, P. Zabel, and K. Dalhoff Disparate Innate Immune Responses to Persistent and Acute Chlamydia pneumoniae Infection in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., April 15, 2007; 175(8): 791 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Foster, S. R. Lea, P. M. Preshaw, and J. J. Taylor Pivotal Advance: Vasoactive intestinal peptide inhibits up-regulation of human monocyte TLR2 and TLR4 by LPS and differentiation of monocytes to macrophages J. Leukoc. Biol., April 1, 2007; 81(4): 893 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Labrum, S. Bevan, M. Sitzer, M. Lorenz, and H. S. Markus Toll Receptor Polymorphisms and Carotid Artery Intima-Media Thickness Stroke, April 1, 2007; 38(4): 1179 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Janciauskiene, I. M. Nita, and T. Stevens {alpha}1-Antitrypsin, Old Dog, New Tricks: {alpha}1-ANTITRYPSIN EXERTS IN VITRO ANTI-INFLAMMATORY ACTIVITY IN HUMAN MONOCYTES BY ELEVATING cAMP J. Biol. Chem., March 23, 2007; 282(12): 8573 - 8582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Sacre, A. M. C. Lundberg, E. Andreakos, C. Taylor, M. Feldmann, and B. M. Foxwell Selective Use of TRAM in Lipopolysaccharide (LPS) and Lipoteichoic Acid (LTA) Induced NF-{kappa}B Activation and Cytokine Production in Primary Human Cells: TRAM Is an Adaptor for LPS and LTA Signaling J. Immunol., February 15, 2007; 178(4): 2148 - 2154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Wolfert, A. Roychowdhury, and G.-J. Boons Modification of the Structure of Peptidoglycan Is a Strategy To Avoid Detection by Nucleotide-Binding Oligomerization Domain Protein 1 Infect. Immun., February 1, 2007; 75(2): 706 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nishitani, H. Mitsuzawa, H. Sano, T. Shimizu, N. Matsushima, and Y. Kuroki Toll-like Receptor 4 Region Glu24-Lys47 Is a Site for MD-2 Binding: IMPORTANCE OF CYS29 AND CYS40 J. Biol. Chem., December 15, 2006; 281(50): 38322 - 38329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Bolz, R. S. Sundsbak, Y. Ma, S. Akira, J. H. Weis, T. G. Schwan, and J. J. Weis Dual Role of MyD88 in Rapid Clearance of Relapsing Fever Borrelia spp. Infect. Immun., December 1, 2006; 74(12): 6750 - 6760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Visintin, K. A. Halmen, N. Khan, B. G. Monks, D. T. Golenbock, and E. Lien MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4) J. Leukoc. Biol., December 1, 2006; 80(6): 1584 - 1592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mitsuzawa, C. Nishitani, N. Hyakushima, T. Shimizu, H. Sano, N. Matsushima, K. Fukase, and Y. Kuroki Recombinant Soluble Forms of Extracellular TLR4 Domain and MD-2 Inhibit Lipopolysaccharide Binding on Cell Surface and Dampen Lipopolysaccharide-Induced Pulmonary Inflammation in Mice J. Immunol., December 1, 2006; 177(11): 8133 - 8139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sato, M. M. Linehan, and A. Iwasaki Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells PNAS, November 14, 2006; 103(46): 17343 - 17348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Du, F. Zhang, J. E. Capo-Aponte, S. D. Tachado, J. Zhang, F.-S. X. Yu, R. A. Sack, H. Koziel, and P. S. Reinach AsialoGM1-Mediated IL-8 Release by Human Corneal Epithelial Cells Requires Coexpression of TLR5 Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4810 - 4818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Koch, P. Hoppmann, A. Pfeufer, A. Schomig, and A. Kastrati Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population Eur. Heart J., November 1, 2006; 27(21): 2524 - 2529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-Y. Lee, S.-C. Ho, H.-C. Lin, S.-M. Lin, C.-Y. Liu, C.-D. Huang, C.-H. Wang, K. F. Chung, and H.-P. Kuo Neutrophil-Derived Elastase Induces TGF-beta1 Secretion in Human Airway Smooth Muscle via NF-{kappa}B Pathway Am. J. Respir. Cell Mol. Biol., October 1, 2006; 35(4): 407 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Arafah Hypothalamic Pituitary Adrenal Function during Critical Illness: Limitations of Current Assessment Methods J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3725 - 3745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Yamada, H. Sano, T. Shimizu, H. Mitsuzawa, C. Nishitani, T. Himi, and Y. Kuroki Surfactant Protein A Directly Interacts with TLR4 and MD-2 and Regulates Inflammatory Cellular Response: IMPORTANCE OF SUPRATRIMERIC OLIGOMERIZATION J. Biol. Chem., August 4, 2006; 281(31): 21771 - 21780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. BRAAT, M. P PEPPELENBOSCH, and D. W HOMMES Immunology of Crohn's disease. Ann. N.Y. Acad. Sci., August 1, 2006; 1072: 135 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wakabayashi, M. Kobayashi, S. Akashi-Takamura, N. Tanimura, K. Konno, K. Takahashi, T. Ishii, T. Mizutani, H. Iba, T. Kouro, et al. A Protein Associated with Toll-Like Receptor 4 (PRAT4A) Regulates Cell Surface Expression of TLR4 J. Immunol., August 1, 2006; 177(3): 1772 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nencioni, K. Schwarzenberg, K. M. Brauer, S. M. Schmidt, A. Ballestrero, F. Grunebach, and P. Brossart Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation Blood, July 15, 2006; 108(2): 551 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rallabhandi, J. Bell, M. S. Boukhvalova, A. Medvedev, E. Lorenz, M. Arditi, V. G. Hemming, J. C. G. Blanco, D. M. Segal, and S. N. Vogel Analysis of TLR4 Polymorphic Variants: New Insights into TLR4/MD-2/CD14 Stoichiometry, Structure, and Signaling J. Immunol., July 1, 2006; 177(1): 322 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Huang, L. D. Hazlett, W. Du, and R. P. Barrett SIGIRR Promotes Resistance against Pseudomonas aeruginosa Keratitis by Down-Regulating Type-1 Immunity and IL-1R1 and TLR4 Signaling J. Immunol., July 1, 2006; 177(1): 548 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, I. Sabroe, J. D. Hasday, and S. N. Vogel Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease Innate Immunity, June 1, 2006; 12(3): 133 - 150. [Abstract] [PDF]
|
|
|
|
 |
|
 Y.-H. Huang, P.-S. Tsai, Y.-F. Kai, C.-H. Yang, and C.-J. Huang Lidocaine inhibition of inducible nitric oxide synthase and cationic amino Acid transporter-2 transcription in activated murine macrophages may involve voltage-sensitive na+ channel. Anesth. Analg., June 1, 2006; 102(6): 1739 - 1744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fang, L. Xu, T. Y. Chen, J. M. Cyr, and D. M. Frucht Anthrax Lethal Toxin Has Direct and Potent Inhibitory Effects on B Cell Proliferation and Immunoglobulin Production J. Immunol., May 15, 2006; 176(10): 6155 - 6161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kobayashi, S.-i. Saitoh, N. Tanimura, K. Takahashi, K. Kawasaki, M. Nishijima, Y. Fujimoto, K. Fukase, S. Akashi-Takamura, and K. Miyake Regulatory Roles for MD-2 and TLR4 in Ligand-Induced Receptor Clustering J. Immunol., May 15, 2006; 176(10): 6211 - 6218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Thorlacius, J. E. Slotta, M. W. Laschke, Y. Wang, M. D. Menger, B. Jeppsson, and H. Thorlacius Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury J. Leukoc. Biol., May 1, 2006; 79(5): 923 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Andersen, D. Al-Khairy, and R. R. Ingalls Innate Immunity at the Mucosal Surface: Role of Toll-Like Receptor 3 and Toll-Like Receptor 9 in Cervical Epithelial Cell Responses to Microbial Pathogens Biol Reprod, May 1, 2006; 74(5): 824 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, J. Alam, and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications Physiol Rev, April 1, 2006; 86(2): 583 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakai, M. B. Kadiiska, J.-J. Jiang, K. Stadler, and R. P. Mason Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin PNAS, March 21, 2006; 103(12): 4616 - 4621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Yang, H. J. Kim, Y. H. Ryu, C.-H. Yun, D. K. Chung, and S. H. Han Endotoxin contamination in commercially available pokeweed mitogen contributes to the activation of murine macrophages and human dendritic cell maturation. Clin. Vaccine Immunol., March 1, 2006; 13(3): 309 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Higgs, P. Cormican, S. Cahalane, B. Allan, A. T. Lloyd, K. Meade, T. James, D. J. Lynn, L. A. Babiuk, and C. O'Farrelly Induction of a Novel Chicken Toll-Like Receptor following Salmonella enterica Serovar Typhimurium Infection Infect. Immun., March 1, 2006; 74(3): 1692 - 1698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhang, S.-H. Wang, M. E. Lasbury, D. Tschang, C.-P. Liao, P. J. Durant, and C.-H. Lee Toll-Like Receptor 2 Mediates Alveolar Macrophage Response to Pneumocystis murina Infect. Immun., March 1, 2006; 74(3): 1857 - 1864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Park, F. Gamboni-Robertson, Q. He, D. Svetkauskaite, J.-Y. Kim, D. Strassheim, J.-W. Sohn, S. Yamada, I. Maruyama, A. Banerjee, et al. High mobility group box 1 protein interacts with multiple Toll-like receptors Am J Physiol Cell Physiol, March 1, 2006; 290(3): C917 - C924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Massari, A. Visintin, J. Gunawardana, K. A. Halmen, C. A. King, D. T. Golenbock, and L. M. Wetzler Meningococcal Porin PorB Binds to TLR2 and Requires TLR1 for Signaling J. Immunol., February 15, 2006; 176(4): 2373 - 2380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mookherjee, K. L. Brown, D. M. E. Bowdish, S. Doria, R. Falsafi, K. Hokamp, F. M. Roche, R. Mu, G. H. Doho, J. Pistolic, et al. Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37 J. Immunol., February 15, 2006; 176(4): 2455 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Harada, K Isse, and Y Nakanuma Interferon {gamma} accelerates NF-{kappa}B activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction J. Clin. Pathol., February 1, 2006; 59(2): 184 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Rosenfeld, N. Papo, and Y. Shai Endotoxin (Lipopolysaccharide) Neutralization by Innate Immunity Host-Defense Peptides: PEPTIDE PROPERTIES AND PLAUSIBLE MODES OF ACTION J. Biol. Chem., January 20, 2006; 281(3): 1636 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. O'Connell, I. A. Ionova, A. J. Quayle, A. Visintin, and R. R. Ingalls Localization of TLR2 and MyD88 to Chlamydia trachomatis Inclusions: EVIDENCE FOR SIGNALING BY INTRACELLULAR TLR2 DURING INFECTION WITH AN OBLIGATE INTRACELLULAR PATHOGEN J. Biol. Chem., January 20, 2006; 281(3): 1652 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Deering and J. S. Orange Development |
