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J Biol Chem, Vol. 274, Issue 17, 11811-11816, April 23, 1999
From the Physiologisches Institut, Albert-Ludwigs-Universität
Freiburg, Hermann-Herder-Straße 7, 79104 Freiburg, Germany
Enhanced osmotic water permeability has been
observed in Xenopus oocytes expressing cystic fibrosis
transmembrane conductance regulator (CFTR) protein. Subsequent studies
have shown that CFTR activates an endogenous water permeability in
oocytes, but that CFTR itself is not the water channel. Here, we show
CFTR-dependent activation of endogenous water permeability
in normal but not in cystic fibrosis human airway epithelial cells.
Cell volume was measured by novel confocal x-z laser scanning
microscopy. Glycerol uptake and antisense studies suggest
CFTR-dependent regulation of aquaporin 3 (AQP3) water
channels in airway epithelial cells. Regulatory interaction was
confirmed by coexpression of CFTR and AQP3 cloned from human airways in
Xenopus oocytes and of CFTR and rat AQP3 in Chinese hamster
ovary cells. These findings indicate that CFTR is a regulator of AQP3
in airway epithelial cells.
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