| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 17, 11889-11896, April 23, 1999
,,,,,,¶
From the Postsynaptic density
(PSD)-95/Synapse-associated protein (SAP) 90 and synaptic scaffolding
molecule (S-SCAM) are neuronal membrane-associated guanylate kinases.
Because PSD-95/SAP90 and S-SCAM function as synaptic scaffolding
proteins, identification of ligands for these proteins is important to
elucidate the structure of synaptic junctions. Here, we report a novel
protein interacting with the PDZ domains of PSD-95/SAP90 and S-SCAM and
named it MAGUIN-1 (membrane-associated guanylate kinase-interacting
protein-1). MAGUIN-1 has one sterile Takai Biotimer Project, Exploratory Research
for Advanced Technology, Japan Science and Technology Corporation, c/o
JCR Pharmaceuticals Co. Ltd., 2-2-10 Murotani, Nishi-ku, Kobe 651-2241, Japan, the § Department of Anatomy and Neurobiology,
Graduate School, Kyoto University, Kyoto 606-8315, Japan, and the
¶ Department of Molecular Biology and Biochemistry, Osaka
University Medical School, Suita 565-0871, Japan
motif, one PDZ, and one
plekstrin homology domain. MAGUIN-1 is localized at the plasma membrane
via the plekstrin homology domain and the C-terminal region
and interacts with PSD-95/SAP90 and S-SCAM via a C-terminal
PDZ domain-binding motif. MAGUIN-1 has a short isoform, MAGUIN-2, which
lacks a PDZ domain-binding motif. MAGUINs are expressed in neurons and
localized in the cell body and neurites and are coimmunoprecipitated
with PSD-95/SAP90 and S-SCAM from rat crude synaptosome. MAGUIN-1 may
play an important role with PSD-95/SAP90 and S-SCAM to assemble the
components of synaptic junctions.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Deng, M. G. Price, C. F. Davis, M. Mori, and D. L. Burgess Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain. J. Neurosci., July 26, 2006; 26(30): 7875 - 7884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kawata, J. Iida, M. Ikeda, Y. Sato, H. Mori, A. Kansaku, K. Sumita, N. Fujiwara, C. Rokukawa, M. Hamano, et al. CIN85 Is Localized at Synapses and Forms a Complex with S-SCAM via Dendrin. J. Biochem., May 1, 2006; 139(5): 931 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ziogas, K. Moelling, and G. Radziwill CNK1 Is a Scaffold Protein That Regulates Src-mediated Raf-1 Activation J. Biol. Chem., June 24, 2005; 280(25): 24205 - 24211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Jaffe, P. Aspenstrom, and A. Hall Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways Mol. Cell. Biol., February 15, 2004; 24(4): 1736 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. LANIGAN, A. LIU, Y. Z. HUANG, L. MEI, B. MARGOLIS, and K.-L. GUAN Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf FASEB J, November 1, 2003; 17(14): 2048 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Yao, J. Iida, W. Nishimura, and Y. Hata Synaptic and Nuclear Localization of Brain-Enriched Guanylate Kinase-Associated Protein J. Neurosci., July 1, 2002; 22(13): 5354 - 5364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Lim, D. D. Hall, and J. W. Hell Selectivity and Promiscuity of the First and Second PDZ Domains of PSD-95 and Synapse-associated Protein 102 J. Biol. Chem., June 7, 2002; 277(24): 21697 - 21711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Nishimura, I. Yao, J. Iida, N. Tanaka, and Y. Hata Interaction of Synaptic Scaffolding Molecule and beta -Catenin J. Neurosci., February 1, 2002; 22(3): 757 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kawabe, H. Nakanishi, M. Asada, A. Fukuhara, K. Morimoto, M. Takeuchi, and Y. Takai Pilt, a Novel Peripheral Membrane Protein at Tight Junctions in Epithelial Cells J. Biol. Chem., December 14, 2001; 276(51): 48350 - 48355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. PATRIE, A. J. DRESCHER, M. GOYAL, R. C. WIGGINS, and B. MARGOLIS The Membrane-Associated Guanylate Kinase Protein MAGI-1 Binds Megalin and Is Present in Glomerular Podocytes J. Am. Soc. Nephrol., April 1, 2001; 12(4): 667 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takai, T. Sasaki, and T. Matozaki Small GTP-Binding Proteins Physiol Rev, January 1, 2001; 81(1): 153 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kawabe, Y. Hata, M. Takeuchi, N. Ide, A. Mizoguchi, and Y. Takai nArgBP2, a Novel Neural Member of Ponsin/ArgBP2/Vinexin Family That Interacts with Synapse-associated Protein 90/Postsynaptic Density-95-associated Protein (SAPAP) J. Biol. Chem., October 22, 1999; 274(43): 30914 - 30918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hanada, L. Lin, E. V. Tibaldi, E. L. Reinherz, and A. H. Chishti GAKIN, a Novel Kinesin-like Protein Associates with the Human Homologue of the Drosophila Discs Large Tumor Suppressor in T Lymphocytes J. Biol. Chem., September 8, 2000; 275(37): 28774 - 28784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-I. Hwang, K. Heo, K.-J. Shin, E. Kim, C.-H. C. Yun, S. H. Ryu, H.-S. Shin, and P.-G. Suh Regulation of Phospholipase C-beta 3 Activity by Na+/H+ Exchanger Regulatory Factor 2 J. Biol. Chem., May 26, 2000; 275(22): 16632 - 16637. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
