| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 18, 12376-12382, April 30, 1999
From the Platelet factor 4 (PF-4) is a platelet-derived
Characterization of a Neutrophil Cell Surface Glycosaminoglycan
That Mediates Binding of Platelet Factor 4
,, and
Department of Medical Biochemistry and
Microbiology, Uppsala University, Biomedical Center, Box 575, S-75123 Uppsala, Sweden and the ¶ Department of Immunology and
Cell Biology, Research Center Borstel, Parkallee 22, D-23845 Borstel, Germany
-chemokine that binds to and activates human neutrophils to undergo
specific functions like exocytosis or adhesion. PF-4 binding has been
shown to be independent of interleukin-8 receptors and could be
inhibited by soluble chondroitin sulfate type glycosaminoglycans or by
pretreatment of cells with chondroitinase ABC. Here we present evidence
that surface-expressed neutrophil glycosaminoglycans are of chondroitin sulfate type and that this species binds to the tetrameric form of
PF-4. The glycosaminoglycans consist of a single type of chain with an
average molecular mass of ~23 kDa and are composed of ~85-90%
chondroitin 4-sulfate disaccharide units type CSA
(
4GlcA
13GalNAc(4-O-sulfate)1) and of
~10-15% di-O-sulfated disaccharide units. A major
part of these di-O-sulfated disaccharide units are CSE
units (4GlcA13GalNAc(4,6-O-sulfate)1). Binding studies revealed that the interaction of chondroitin sulfate with PF-4 required at least 20 monosaccharide units for significant binding. The di-O-sulfated disaccharide units in neutrophil
glycosaminoglycans clearly promoted the affinity to PF-4, which showed
a Kd ~ 0.8 µM, as the affinities of
bovine cartilage chondroitin sulfate A, porcine skin dermatan sulfate,
or bovine cartilage chondroitin sulfate C, all consisting exclusively
of monosulfated disaccharide units, were found to be 3-5-fold lower.
Taken together, our data indicate that chondroitin sulfate chains
function as physiologically relevant binding sites for PF-4 on
neutrophils and that the affinity of these chains for PF-4 is
controlled by their degree of sulfation.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Cebe-Suarez, F. S. Grunewald, R. Jaussi, X. Li, L. Claesson-Welsh, D. Spillmann, A. A. Mercer, A. E. Prota, and K. Ballmer-Hofer Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR FASEB J, August 1, 2008; 22(8): 3078 - 3086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mueller, A. Meiser, E. M. McDonagh, J. M. Fox, S. J. Petit, G. Xanthou, T. J. Williams, and J. E. Pease CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3 J. Leukoc. Biol., April 1, 2008; 83(4): 875 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kasper, E. Brandt, S. Brandau, and F. Petersen Platelet Factor 4 (CXC Chemokine Ligand 4) Differentially Regulates Respiratory Burst, Survival, and Cytokine Expression of Human Monocytes by Using Distinct Signaling Pathways J. Immunol., August 15, 2007; 179(4): 2584 - 2591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Campbell and C. A. Owen The Sulfate Groups of Chondroitin Sulfate- and Heparan Sulfate-containing Proteoglycans in Neutrophil Plasma Membranes Are Novel Binding Sites for Human Leukocyte Elastase and Cathepsin G J. Biol. Chem., May 11, 2007; 282(19): 14645 - 14654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Schiemann, T. A. Grimm, J. Hoch, R. Gross, B. Lindner, F. Petersen, S. Bulfone-Paus, and E. Brandt Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G Blood, March 15, 2006; 107(6): 2234 - 2242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kasper, E. Brandt, M. Ernst, and F. Petersen Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases Blood, March 1, 2006; 107(5): 1768 - 1775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Taylor and R. L. Gallo Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation FASEB J, January 1, 2006; 20(1): 9 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tiedemann, B. Olander, E. Eklund, L. Todorova, M. Bengtsson, M. Maccarana, G. Westergren-Thorsson, and A. Malmstrom Regulation of the chondroitin/dermatan fine structure by transforming growth factor-{beta}1 through effects on polymer-modifying enzymes Glycobiology, December 1, 2005; 15(12): 1277 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pervushina, B. Scheuerer, N. Reiling, L. Behnke, Jens.-M. Schroder, B. Kasper, E. Brandt, S. Bulfone-Paus, and F. Petersen Platelet Factor 4/CXCL4 Induces Phagocytosis and the Generation of Reactive Oxygen Metabolites in Mononuclear Phagocytes Independently of Gi Protein Activation or Intracellular Calcium Transients J. Immunol., August 1, 2004; 173(3): 2060 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kasper, E. Brandt, S. Bulfone-Paus, and F. Petersen Platelet factor 4 (PF-4)-induced neutrophil adhesion is controlled by src-kinases, whereas PF-4-mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase Blood, March 1, 2004; 103(5): 1602 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Z. Dudek, I. Nesmelova, K. Mayo, C. M. Verfaillie, S. Pitchford, and A. Slungaard Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis Blood, June 15, 2003; 101(12): 4687 - 4694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Marti, E. Bertran, M. Llucia, E. Villen, M. Peiro, J. Garcia, and F. Rueda Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8 J. Leukoc. Biol., September 1, 2002; 72(3): 590 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. I. Schenk, F. Petersen, H.-D. Flad, and E. Brandt Platelet-Derived Chemokines CXC Chemokine Ligand (CXCL)7, Connective Tissue-Activating Peptide III, and CXCL4 Differentially Affect and Cross-Regulate Neutrophil Adhesion and Transendothelial Migration J. Immunol., September 1, 2002; 169(5): 2602 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fleischer, E. Grage-Griebenow, B. Kasper, H. Heine, M. Ernst, E. Brandt, H.-D. Flad, and F. Petersen Platelet Factor 4 Inhibits Proliferation and Cytokine Release of Activated Human T Cells J. Immunol., July 15, 2002; 169(2): 770 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Sachais, A. Kuo, T. Nassar, J. Morgan, K. Kariko, K. J. Williams, M. Feldman, M. Aviram, N. Shah, L. Jarett, et al. Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic itinerary, resulting in retention of low-density lipoprotein on the cell surface Blood, May 15, 2002; 99(10): 3613 - 3622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kawashima, K. Atarashi, M. Hirose, J. Hirose, S. Yamada, K. Sugahara, and M. Miyasaka Oversulfated Chondroitin/Dermatan Sulfates Containing GlcAbeta 1/IdoAalpha 1-3GalNAc(4,6-O-disulfate) Interact with L- and P-selectin and Chemokines J. Biol. Chem., April 5, 2002; 277(15): 12921 - 12930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lortat-Jacob, A. Grosdidier, and A. Imberty Structural diversity of heparan sulfate binding domains in chemokines PNAS, February 5, 2002; 99(3): 1229 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mardberg, E. Trybala, F. Tufaro, and T. Bergstrom Herpes simplex virus type 1 glycoprotein C is necessary for efficient infection of chondroitin sulfate-expressing gro2C cells J. Gen. Virol., February 1, 2002; 83(2): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ohtake, Y. Ito, M. Fukuta, and O. Habuchi Human N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase cDNA Is Related to Human B Cell Recombination Activating Gene-associated Gene J. Biol. Chem., November 16, 2001; 276(47): 43894 - 43900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barragan, V. Fernandez, Q. Chen, A. von Euler, M. Wahlgren, and D. Spillmann The Duffy-binding-like domain 1 of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a heparan sulfate ligand that requires 12 mers for binding Blood, June 1, 2000; 95(11): 3594 - 3599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kishibe, S. Yamada, Y. Okada, J. Sato, A. Ito, K. Miyazaki, and K. Sugahara Structural Requirements of Heparan Sulfate for the Binding to the Tumor-derived Adhesion Factor/Angiomodulin That Induces Cord-like Structures to ECV-304 Human Carcinoma Cells J. Biol. Chem., May 12, 2000; 275(20): 15321 - 15329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sassetti, A. Van Zante, and S. D. Rosen Identification of Endoglycan, a Member of the CD34/Podocalyxin Family of Sialomucins J. Biol. Chem., March 17, 2000; 275(12): 9001 - 9010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Scheuerer, M. Ernst, I. Durrbaum-Landmann, J. Fleischer, E. Grage-Griebenow, E. Brandt, H.-D. Flad, and F. Petersen The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages Blood, February 15, 2000; 95(4): 1158 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Safaiyan, S. O. Kolset, K. Prydz, E. Gottfridsson, U. Lindahl, and M. Salmivirta Selective Effects of Sodium Chlorate Treatment on the Sulfation of Heparan Sulfate J. Biol. Chem., December 17, 1999; 274(51): 36267 - 36273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kawashima, M. Hirose, J. Hirose, D. Nagakubo, A. H. K. Plaas, and M. Miyasaka Binding of a Large Chondroitin Sulfate/Dermatan Sulfate Proteoglycan, Versican, to L-selectin, P-selectin, and CD44 J. Biol. Chem., November 3, 2000; 275(45): 35448 - 35456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bengtsson, A. Aspberg, D. Heinegard, Y. Sommarin, and D. Spillmann The Amino-terminal Part of PRELP Binds to Heparin and Heparan Sulfate J. Biol. Chem., December 22, 2000; 275(52): 40695 - 40702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ito and O. Habuchi Purification and Characterization of N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase from the Squid Cartilage J. Biol. Chem., October 27, 2000; 275(44): 34728 - 34736. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
