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J Biol Chem, Vol. 274, Issue 18, 12650-12655, April 30, 1999
,,
From the In Plasmodium-infected mosquitoes,
oocysts are preferentially located at the posterior half of the
posterior midgut. Because mosquitoes rest vertically after feeding, the
effect of gravity on the ingested blood has been proposed as the cause
of such a biased distribution. In this paper, we examined the oocyst
distribution on the midguts of mosquitoes that were continuously
rotated to nullify the effect of gravity and found that the typical
pattern of oocyst distribution did not change. Invasion of the midgut epithelium by ookinetes was similarly found to be biased toward the
posterior part of the posterior midgut. We examined whether the
distribution of oocysts depends on the distribution of vesicular ATPase
(V-ATPase)-overexpressing cells that Plasmodium ookinetes preferentially use to cross the midgut epithelium. An antiserum raised
against recombinant Aedes aegypti V-ATPase B subunit
indicated that the majority of V-ATPase-overexpressing cells in
Ae. aegypti and Anopheles gambiae are localized
at the posterior part of the posterior midgut. We propose that the
typical distribution of oocysts on the mosquito midgut is
attributable to the presence and the spatial distribution
of the V-ATPase-overexpressing cells in the midgut epithelium.
Medical Entomology Section and the
¶ Malaria Genetics Section, Laboratory of Parasitic Diseases,
NIAID, National Institutes of Health, Bethesda, Maryland 20892-0425
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