| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 19, 12955-12958, May 7, 1999
B
From Millennium Pharmaceuticals, Inc.,
Cambridge, Massachusetts 02139
The nematode CED-4 protein and its human homolog
Apaf-1 play a central role in apoptosis by functioning as direct
activators of death-inducing caspases. A novel human CED-4/Apaf-1
family member called CARD4 was identified that has a domain structure strikingly similar to the cytoplasmic, receptor-like proteins that
mediate disease resistance in plants. CARD4 interacted with the
serine-threonine kinase RICK and potently induced NF-
B activity through TRAF-6 and NIK signaling molecules. In addition, coexpression of CARD4 augmented caspase-9-induced apoptosis. Thus, CARD4 coordinates downstream NF-B and apoptotic signaling pathways and may be a component of the host innate immune response.
This article has been cited by other articles:
|
|
 |
|
  J. M. Wilmanski, T. Petnicki-Ocwieja, and K. S. Kobayashi NLR proteins: integral members of innate immunity and mediators of inflammatory diseases J. Leukoc. Biol., January 1, 2008; 83(1): 13 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Barton, T. Berg, L. Didon, and M. Nord The pattern recognition receptor Nod1 activates CCAAT/enhancer binding protein {beta} signalling in lung epithelial cells Eur. Respir. J., August 1, 2007; 30(2): 214 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sarkar, M. Duncan, J. Hart, E. Hertlein, D. C. Guttridge, and M. D. Wewers ASC Directs NF-{kappa}B Activation by Regulating Receptor Interacting Protein-2 (RIP2) Caspase-1 Interactions. J. Immunol., April 15, 2006; 176(8): 4979 - 4986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Traub, S. von Aulock, T. Hartung, and C. Hermann Invited review: MDP and other muropeptides direct and synergistic effects on the immune system Innate Immunity, April 1, 2006; 12(2): 69 - 85. [Abstract] [PDF]
|
|
|
|
 |
|
 J. da Silva Correia, Y. Miranda, N. Austin-Brown, J. Hsu, J. Mathison, R. Xiang, H. Zhou, Q. Li, J. Han, and R. J. Ulevitch Nod1-dependent control of tumor growth PNAS, February 7, 2006; 103(6): 1840 - 1845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Netea, G. Ferwerda, D. J. de Jong, C. Werts, I. G. Boneca, M. Jehanno, J. W. M. Van Der Meer, D. Mengin-Lecreulx, P. J. Sansonetti, D. J. Philpott, et al. The Frameshift Mutation in Nod2 Results in Unresponsiveness Not Only to Nod2- but Also Nod1-activating Peptidoglycan Agonists J. Biol. Chem., October 28, 2005; 280(43): 35859 - 35867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamamoto, T. Torigoe, K. Kamiguchi, Y. Hirohashi, K. Nakanishi, C. Nabeta, H. Asanuma, T. Tsuruma, T. Sato, F. Hata, et al. A Novel Isoform of TUCAN Is Overexpressed in Human Cancer Tissues and Suppresses Both Caspase-8- and Caspase-9-Mediated Apoptosis Cancer Res., October 1, 2005; 65(19): 8706 - 8714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Haferlach, A. Kohlmann, S. Schnittger, M. Dugas, W. Hiddemann, W. Kern, and C. Schoch Global approach to the diagnosis of leukemia using gene expression profiling Blood, August 15, 2005; 106(4): 1189 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Barnich, J. E. Aguirre, H.-C. Reinecker, R. Xavier, and D. K. Podolsky Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition J. Cell Biol., July 4, 2005; 170(1): 21 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Barnich, T. Hisamatsu, J. E. Aguirre, R. Xavier, H.-C. Reinecker, and D. K. Podolsky GRIM-19 Interacts with Nucleotide Oligomerization Domain 2 and Serves as Downstream Effector of Anti-bacterial Function in Intestinal Epithelial Cells J. Biol. Chem., May 13, 2005; 280(19): 19021 - 19026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Marriott, D. M. Rati, S. H. McCall, and S. L. Tranguch Induction of Nod1 and Nod2 Intracellular Pattern Recognition Receptors in Murine Osteoblasts following Bacterial Challenge Infect. Immun., May 1, 2005; 73(5): 2967 - 2973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lu, A. Wang, M. Dorsch, J. Tian, K. Nagashima, A. J. Coyle, B. Jaffee, T. D. Ocain, and Y. Xu Participation of Rip2 in Lipopolysaccharide Signaling Is Independent of Its Kinase Activity J. Biol. Chem., April 22, 2005; 280(16): 16278 - 16283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hasegawa, R. Imamura, T. Kinoshita, N. Matsumoto, J. Masumoto, N. Inohara, and T. Suda ASC-mediated NF-{kappa}B Activation Leading to Interleukin-8 Production Requires Caspase-8 and Is Inhibited by CLARP J. Biol. Chem., April 15, 2005; 280(15): 15122 - 15130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Horikawa, N. J. Kirkman, K. E. Mayo, S. M. Mulders, J. Zhou, C. A. Bondy, S.-Y. T. Hsu, G. J. King, and E. Y. Adashi The Mouse Germ-Cell-Specific Leucine-Rich Repeat Protein NALP14: A Member of the NACHT Nucleoside Triphosphatase Family Biol Reprod, April 1, 2005; 72(4): 879 - 889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Opitz, S. Forster, A. C. Hocke, M. Maass, B. Schmeck, S. Hippenstiel, N. Suttorp, and M. Krull Nod1-Mediated Endothelial Cell Activation by Chlamydophila pneumoniae Circ. Res., February 18, 2005; 96(3): 319 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Gasche and P Grundtner Genotypes and phenotypes in Crohn's disease: do they help in clinical management? Gut, January 1, 2005; 54(1): 162 - 167. [Full Text] [PDF]
|
|
|
|
|
|
B. Opitz, A. Puschel, B. Schmeck, A. C. Hocke, S. Rosseau, S. Hammerschmidt, R. R. Schumann, N. Suttorp, and S. Hippenstiel Nucleotide-binding Oligomerization Domain Proteins Are Innate Immune Receptors for Internalized Streptococcus pneumoniae J. Biol. Chem., August 27, 2004; 279(35): 36426 - 36432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, M. Hasegawa, R. Imamura, T. Kinoshita, C. Kondo, K. Konaka, and T. Suda PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1 Int. Immunol., June 1, 2004; 16(6): 777 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Kim, S. J. Lee, and M. F. Kagnoff Nod1 Is an Essential Signal Transducer in Intestinal Epithelial Cells Infected with Bacteria That Avoid Recognition by Toll-Like Receptors Infect. Immun., March 1, 2004; 72(3): 1487 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Andrews and K. E. Sullivan Infections in Patients with Inherited Defects in Phagocytic Function Clin. Microbiol. Rev., October 1, 2003; 16(4): 597 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hisamatsu, M. Suzuki, and D. K. Podolsky Interferon-{gamma} Augments CARD4/NOD1 Gene and Protein Expression through Interferon Regulatory Factor-1 in Intestinal Epithelial Cells J. Biol. Chem., August 29, 2003; 278(35): 32962 - 32968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stehlik, H. Hayashi, F. Pio, A. Godzik, and J. C. Reed CARD6 Is a Modulator of NF-{kappa}B Activation by Nod1- and Cardiak-mediated Pathways J. Biol. Chem., August 22, 2003; 278(34): 31941 - 31949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Girardin, I. G. Boneca, L. A. M. Carneiro, A. Antignac, M. Jehanno, J. Viala, K. Tedin, M.-K. Taha, A. Labigne, U. Zathringer, et al. Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan Science, June 6, 2003; 300(5625): 1584 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Garcia-Domingo, D. Ramirez, G. Gonzalez de Buitrago, and C. Martinez-A Death Inducer-Obliterator 1 Triggers Apoptosis after Nuclear Translocation and Caspase Upregulation Mol. Cell. Biol., May 1, 2003; 23(9): 3216 - 3225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Girardin, I. G. Boneca, J. Viala, M. Chamaillard, A. Labigne, G. Thomas, D. J. Philpott, and P. J. Sansonetti Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection J. Biol. Chem., March 7, 2003; 278(11): 8869 - 8872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Harton, M. W. Linhoff, J. Zhang, and J. P.-Y. Ting Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains J. Immunol., October 15, 2002; 169(8): 4088 - 4093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Furukawa, N. Nishimura, Y. Furukawa, M. Satoh, H. Endo, S. Iwase, H. Yamada, M. Matsuda, Y. Kano, and M. Nakamura Apaf-1 Is a Mediator of E2F-1-induced Apoptosis J. Biol. Chem., October 11, 2002; 277(42): 39760 - 39768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Muto, J. Ruland, L. M. McAllister-Lucas, P. C. Lucas, S. Yamaoka, F. F. Chen, A. Lin, T. W. Mak, G. Nunez, and N. Inohara Protein Kinase C-associated Kinase (PKK) Mediates Bcl10-independent NF-kappa B Activation Induced by Phorbol Ester J. Biol. Chem., August 23, 2002; 277(35): 31871 - 31876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, G. A. Manji, J. M. Grenier, A. Al-Garawi, S. Merriam, J. M. Lora, B. J. Geddes, M. Briskin, P. S. DiStefano, and J. Bertin PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-kappa B and Caspase-1-dependent Cytokine Processing J. Biol. Chem., August 9, 2002; 277(33): 29874 - 29880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Srinivasula, J.-L. Poyet, M. Razmara, P. Datta, Z. Zhang, and E. S. Alnemri The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1 J. Biol. Chem., June 7, 2002; 277(24): 21119 - 21122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Stephanou, T. M. Scarabelli, R. A. Knight, and D. S. Latchman Antiapoptotic Activity of the Free Caspase Recruitment Domain of Procaspase-9. A NOVEL ENDOGENOUS RESCUE PATHWAY IN CELL DEATH J. Biol. Chem., April 12, 2002; 277(16): 13693 - 13699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Razmara, S. M. Srinivasula, L. Wang, J.-L. Poyet, B. J. Geddes, P. S. DiStefano, J. Bertin, and E. S. Alnemri CARD-8 Protein, a New CARD Family Member That Regulates Caspase-1 Activation and Apoptosis J. Biol. Chem., April 12, 2002; 277(16): 13952 - 13958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Manji, L. Wang, B. J. Geddes, M. Brown, S. Merriam, A. Al-Garawi, S. Mak, J. M. Lora, M. Briskin, M. Jurman, et al. PYPAF1, a PYRIN-containing Apaf1-like Protein That Assembles with ASC and Regulates Activation of NF-kappa B J. Biol. Chem., March 22, 2002; 277(13): 11570 - 11575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Vasselon and P. A. Detmers Toll Receptors: a Central Element in Innate Immune Responses Infect. Immun., March 1, 2002; 70(3): 1033 - 1041. [Full Text] [PDF]
|
|
|
|
|
|
L. Bouchier-Hayes, H. Conroy, H. Egan, C. Adrain, E. M. Creagh, M. MacFarlane, and S. J. Martin CARDINAL, a Novel Caspase Recruitment Domain Protein, Is an Inhibitor of Multiple NF-kappa B Activation Pathways J. Biol. Chem., November 16, 2001; 276(47): 44069 - 44077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Silverman and T. Maniatis NF-{kappa}B signaling pathways in mammalian and insect innate immunity Genes & Dev., September 15, 2001; 15(18): 2321 - 2342. [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Fairbrother, N. C. Gordon, E. W. Humke, K. M. O'rourke, M. A. Starovasnik, J.-P. Yin, and V. M. Dixit The PYRIN domain: A member of the death domain-fold superfamily Protein Sci., September 1, 2001; 10(9): 1911 - 1918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Sisk, S. Roys, and C.-H. Chang Self-Association of CIITA and Its Transactivation Potential Mol. Cell. Biol., August 1, 2001; 21(15): 4919 - 4928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wiszniewski, M.-C. Fondaneche, F. Le Deist, M. Kanariou, F. Selz, N. Brousse, V. Steimle, G. Barbieri, C. Alcaide-Loridan, D. Charron, et al. Mutation in the Class II trans-Activator Leading to a Mild Immunodeficiency J. Immunol., August 1, 2001; 167(3): 1787 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Alexander and E. Th. Rietschel Invited review: Bacterial lipopolysaccharides and innate immunity Innate Immunity, June 1, 2001; 7(3): 167 - 202. [Abstract] [PDF]
|
|
|
|
|
|
M. W. Linhoff, J. A. Harton, D. E. Cressman, B. K. Martin, and J. P.-Y. Ting Two Distinct Domains within CIITA Mediate Self-Association: Involvement of the GTP-Binding and Leucine-Rich Repeat Domains Mol. Cell. Biol., May 1, 2001; 21(9): 3001 - 3011. [Abstract] [Full Text]
|
|
|
|
|
|
N. Droin, M. Beauchemin, E. Solary, and R. Bertrand Identification of a Caspase-2 Isoform that Behaves as an Endogenous Inhibitor of the Caspase Cascade Cancer Res., December 1, 2000; 60(24): 7039 - 7047. [Abstract] [Full Text]
|
|
|
|
|
|
K. E. Conway, B. B. McConnell, C. E. Bowring, C. D. Donald, S. T. Warren, and P. M. Vertino TMS1, a Novel Proapoptotic Caspase Recruitment Domain Protein, Is a Target of Methylation-induced Gene Silencing in Human Breast Cancers Cancer Res., November 1, 2000; 60(22): 6236 - 6242. [Abstract] [Full Text]
|
|
|
|
|
|
B. B. McConnell and P. M. Vertino Activation of a Caspase-9-mediated Apoptotic Pathway by Subcellular Redistribution of the Novel Caspase Recruitment Domain Protein TMS1 Cancer Res., November 1, 2000; 60(22): 6243 - 6247. [PDF]
|
|
|
|
 |
|
 J. C. Reed Mechanisms of Apoptosis Am. J. Pathol., November 1, 2000; 157(5): 1415 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Lomaga, J. T. Henderson, A. J. Elia, J. Robertson, R. S. Noyce, W.-C. Yeh, and T. W. Mak Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Deficiency Results in Exencephaly and Is Required for Apoptosis within the Developing CNS J. Neurosci., October 1, 2000; 20(19): 7384 - 7393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Dixon, C. Golstein, C. M. Thomas, E. A. van der Biezen, and J. D. G. Jones Genetic complexity of pathogen perception by plants: The example of Rcr3, a tomato gene required specifically by Cf-2 PNAS, August 1, 2000; 97(16): 8807 - 8814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ray, G. Chen, C. Vande Velde, J. Cizeau, J. H. Park, J. C. Reed, R. D. Gietz, and A. H. Greenberg BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites J. Biol. Chem., January 14, 2000; 275(2): 1439 - 1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Tai, D. Dahlbeck, E. T. Clark, P. Gajiwala, R. Pasion, M. C. Whalen, R. E. Stall, and B. J. Staskawicz Expression of the Bs2 pepper gene confers resistance to bacterial spot disease in tomato PNAS, November 23, 1999; 96(24): 14153 - 14158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Moriishi, D. C. S. Huang, S. Cory, and J. M. Adams Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1 PNAS, August 17, 1999; 96(17): 9683 - 9688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bertin, Y. Guo, L. Wang, S. M. Srinivasula, M. D. Jacobson, J.-L. Poyet, S. Merriam, M.-Q. Du, M. J. S. Dyer, K. E. Robison, et al. CARD9 Is a Novel Caspase Recruitment Domain-containing Protein That Interacts With BCL10/CLAP and Activates NF-kappa B J. Biol. Chem., December 22, 2000; 275(52): 41082 - 41086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Poyet, S. M. Srinivasula, M. Tnani, M. Razmara, T. Fernandes-Alnemri, and E. S. Alnemri Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1 J. Biol. Chem., July 20, 2001; 276(30): 28309 - 28313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Inohara, T. Koseki, J. Lin, L. del Peso, P. C. Lucas, F. F. Chen, Y. Ogura, and G. Nunez An Induced Proximity Model for NF-kappa B Activation in the Nod1/RICK and RIP Signaling Pathways J. Biol. Chem., September 1, 2000; 275(36): 27823 - 27831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-L. Chu, F. Pio, Z. Xie, K. Welsh, M. Krajewska, S. Krajewski, A. Godzik, and J. C. Reed A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis J. Biol. Chem., March 16, 2001; 276(12): 9239 - 9245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ogura, N. Inohara, A. Benito, F. F. Chen, S. Yamaoka, and G. Nunez Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-kappa B J. Biol. Chem., February 9, 2001; 276(7): 4812 - 4818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Inohara, Y. Ogura, F. F. Chen, A. Muto, and G. Nunez Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides J. Biol. Chem., January 19, 2001; 276(4): 2551 - 2554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hlaing, R.-F. Guo, K. A. Dilley, J. M. Loussia, T. A. Morrish, M. M. Shi, C. Vincenz, and P. A. Ward Molecular Cloning and Characterization of DEFCAP-L and -S, Two Isoforms of a Novel Member of the Mammalian Ced-4 Family of Apoptosis Proteins J. Biol. Chem., March 16, 2001; 276(12): 9230 - 9238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bertin, L. Wang, Y. Guo, M. D. Jacobson, J.-L. Poyet, S. M. Srinivasula, S. Merriam, P. S. DiStefano, and E. S. Alnemri CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-kappa B J. Biol. Chem., April 6, 2001; 276(15): 11877 - 11882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, Y. Guo, W.-J. Huang, X. Ke, J.-L. Poyet, G. A. Manji, S. Merriam, M. A. Glucksmann, P. S. DiStefano, E. S. Alnemri, et al. CARD10 Is a Novel Caspase Recruitment Domain/Membrane-associated Guanylate Kinase Family Member That Interacts with BCL10 and Activates NF-kappa B J. Biol. Chem., June 8, 2001; 276(24): 21405 - 21409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Choi, K.-B. Kim, H.-H. Kim, G.-S. Hong, Y.-K. Kwon, C.-W. Chung, Y.-M. Park, Z.-J. Shen, B. J. Kim, S.-Y. Lee, et al. FLASH Coordinates NF-kappa B Activity via TRAF2 J. Biol. Chem., June 29, 2001; 276(27): 25073 - 25077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Neuss, R. Monticone, M. S. Lundberg, A. T. Chesley, E. Fleck, and M. T. Crow The Apoptotic Regulatory Protein ARC (Apoptosis Repressor with Caspase Recruitment Domain) Prevents Oxidant Stress-mediated Cell Death by Preserving Mitochondrial Function J. Biol. Chem., August 31, 2001; 276(36): 33915 - 33922. [Abstract] [Full Text] [PDF] |
