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J Biol Chem, Vol. 274, Issue 19, 12963-12966, May 7, 1999
From the Programa de Biologia Celular y Molecular, Instituto de
Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile,
Santiago 7, Chile
A mammalian protein highly homologous to
TATA-binding protein (TBP) has been identified and cloned. The
recombinant mammalian TBP-related factor binds to the TATA box of the
Ad-MLP and forms stable complexes with TFIIB on the promoter DNA. The
mammalian TBP-related factor is able to substitute for TBP in
supporting transcription by RNA polymerase II in an in
vitro reconstituted system.
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