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J Biol Chem, Vol. 274, Issue 2, 559-562, January 8, 1999
,
, and
§¶
From the P84 (also known as SHPS-1, BIT, and SIRP) is a
heterophilic adhesive membrane protein involved in receptor tyrosine
kinase signaling that is found at synapses in the mammalian central
nervous system and in non-neural tissues. We have identified a binding partner for P84 using an expression cloning strategy. Here we report
that integrin-associated protein (IAP/CD47) is a predominant binding
partner of P84. Immunohistochemistry reveals a virtually identical
distribution of P84 and IAP in a variety of adult brain regions.
Because IAP has been implicated in cell signaling in cells of the
immune system, P84 and IAP represent a heterophilic binding pair that
is likely to be involved in bi-directional signaling at the synapse and
in other tissues.
Department of Neurobiology and the
§ Department of Pediatrics,
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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