| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 2, 607-617, January 8, 1999
From INSERM U119, 27 Boulevard Lei Roure,
13009 Marseille, France
The Tec protein-tyrosine kinase family includes
Btk, Itk/Tsk/Emt, Tec, Rlk/Txk, and Bmx which are involved in signals
mediated by various cytokines or antigen receptors. Itk is expressed
primarily in T cells and activated by TCR/CD3, CD28, and CD2. However,
the defect in T cell signaling in itk-deficient mice is
very modest. Thus, we looked for other Tec family kinases that could be
expressed in lymphoid cells and involved in T cell signal transduction. Here, we demonstrate that Tec, expressed in T cells, is activated following TCR/CD3 or CD28 ligation and interacts with CD28 receptor in
an activation-dependent manner. This interaction involves
the Tec SH3 domain and the proline-rich motifs in CD28. We also show that Tec can phosphorylate p62dok, one CD28-specific substrate,
whereas Itk cannot. Overexpression of Tec but not Itk can enhance the
interleukin-2 promoter activity mediated by TCR/CD3 or CD28 stimulation
and introduction of a kinase-dead Tec but not Itk can suppress
interleukin-2 expression, indicating that Tec is directly involved in T
cell activation. Altogether, these data demonstrate that Tec kinase is
an integral component of T cell signaling and that the two Tec family
kinases, Tec and Itk, have distinct roles in T cell activation.
This article has been cited by other articles:
|
|
 |
|
  T. Yasuda, K. Bundo, A. Hino, K. Honda, A. Inoue, M. Shirakata, M. Osawa, T. Tamura, H. Nariuchi, H. Oda, et al. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling Int. Immunol., April 1, 2007; 19(4): 487 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. L. Tamma, S. P. Balan, K. W. Chung, and S. Pahwa The lectin jacalin plus costimulation with anti-CD28 antibody induces phosphorylation of p38 MAPK and IL-4 synthesis-I J. Leukoc. Biol., April 1, 2006; 79(4): 876 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bernard, B. Riteau, J. D. Hansen, R. B. Phillips, F. Michel, P. Boudinot, and A. Benmansour Costimulatory Receptors in a Teleost Fish: Typical CD28, Elusive CTLA4 J. Immunol., April 1, 2006; 176(7): 4191 - 4200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Boulay, J.-G. Nemorin, and P. Duplay Phosphotyrosine Binding-Mediated Oligomerization of Downstream of Tyrosine Kinase (Dok)-1 and Dok-2 Is Involved in CD2-Induced Dok Phosphorylation J. Immunol., October 1, 2005; 175(7): 4483 - 4489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-N. Lee, C. C. Malbon, and H.-y. Wang G{alpha}13 Signals via p115RhoGEF Cascades Regulating JNK1 and Primitive Endoderm Formation J. Biol. Chem., December 24, 2004; 279(52): 54896 - 54904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Garcon, G. Bismuth, D. Isnardon, D. Olive, and J. A. Nunes Tec Kinase Migrates to the T Cell-APC Interface Independently of Its Pleckstrin Homology Domain J. Immunol., July 15, 2004; 173(2): 770 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Tomlinson, L. P. Kane, J. Su, T. A. Kadlecek, M. N. Mollenauer, and A. Weiss Expression and Function of Tec, Itk, and Btk in Lymphocytes: Evidence for a Unique Role for Tec Mol. Cell. Biol., March 15, 2004; 24(6): 2455 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Michel and O. Acuto CD28 Costimulation: A Source of Vav-1 for TCR Signaling with the Help of SLP-76? Sci. Signal., August 6, 2002; 2002(144): pe35 - pe35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lachance, S. Levasseur, and P. H. Naccache Chemotactic Factor-induced Recruitment and Activation of Tec Family Kinases in Human Neutrophils. IMPLICATION OF PHOSPHATIDYLINOSITOL 3-KINASES J. Biol. Chem., June 7, 2002; 277(24): 21537 - 21541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liang, D. Wisniewski, A. Strife, Shivakrupa, B. Clarkson, and M. D. Resh Phosphatidylinositol 3-Kinase and Src Family Kinases Are Required for Phosphorylation and Membrane Recruitment of Dok-1 in c-Kit Signaling J. Biol. Chem., April 12, 2002; 277(16): 13732 - 13738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Takesono, L. D. Finkelstein, and P. L. Schwartzberg Beyond calcium: new signaling pathways for Tec family kinases J. Cell Sci., January 8, 2002; 115(15): 3039 - 3048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Di Cristofano, M. Niki, M. Zhao, F. G. Karnell, B. Clarkson, W. S. Pear, L. Van Aelst, and P. P. Pandolfi p62dok, a Negative Regulator of Ras and Mitogen-activated Protein Kinase (MAPK) Activity, Opposes Leukemogenesis by p210bcr-abl J. Exp. Med., July 30, 2001; 194(3): 275 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Kline, D. J. Moore, and C. V. Clevenger Activation and Association of the Tec Tyrosine Kinase with the Human Prolactin Receptor: Mapping of a Tec/Vav1-Receptor Binding Site Mol. Endocrinol., May 1, 2001; 15(5): 832 - 841. [Abstract] [Full Text]
|
|
|
|
|
|
J.-G. Nemorin, P. Laporte, G. Berube, and P. Duplay p62dok Negatively Regulates CD2 Signaling in Jurkat Cells J. Immunol., April 1, 2001; 166(7): 4408 - 4415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bony, S. Roche, U. Shuichi, T. Sasaki, M. A. Crackower, J. Penninger, H. Mano, and M. Puceat A Specific Role of Phosphatidylinositol 3-Kinase {gamma}: A Regulation of Autonomic Ca2+ Oscillations in Cardiac Cells J. Cell Biol., February 20, 2001; 152(4): 717 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Yang, K. A. Ching, C. D. Tsoukas, and L. J. Berg Tec Kinase Signaling in T Cells Is Regulated by Phosphatidylinositol 3-Kinase and the Tec Pleckstrin Homology Domain J. Immunol., January 1, 2001; 166(1): 387 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ellmeier, S. Jung, M. J. Sunshine, F. Hatam, Y. Xu, D. Baltimore, H. Mano, and D. R. Littman Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk J. Exp. Med., December 4, 2000; 192(11): 1611 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Yang, M. Ghiotto, R. Castellano, Y. Collette, N. Auphan, J. A. Nunes, and D. Olive Role of Tec kinase in nuclear factor of activated T cells signaling Int. Immunol., November 1, 2000; 12(11): 1547 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Sylla, K. Murphy, E. Cahir-McFarland, W. S. Lane, G. Mosialos, and E. Kieff The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B PNAS, June 13, 2000; (2000) 130193097. [Abstract] [Full Text]
|
|
|
|
|
|
J.-G. Nemorin and P. Duplay Evidence That Lck-mediated Phosphorylation of p56dok and p62dok May Play a Role in CD2 Signaling J. Biol. Chem., May 5, 2000; 275(19): 14590 - 14597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Perez-Villar and S. B. Kanner Regulated Association Between the Tyrosine Kinase Emt/Itk/Tsk and Phospholipase-C{gamma}1 in Human T Lymphocytes J. Immunol., December 15, 1999; 163(12): 6435 - 6441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rajagopal, C. L. Sommers, D. C. Decker, E. O. Mitchell, U. Korthauer, A. I. Sperling, C. A. Kozak, P. E. Love, and J. A. Bluestone RIBP, a Novel Rlk/Txk- and Itk-binding Adaptor Protein That Regulates T Cell Activation J. Exp. Med., December 6, 1999; 190(11): 1657 - 1668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Ohya, S. Kajigaya, A. Kitanaka, K. Yoshida, A. Miyazato, Y. Yamashita, T. Yamanaka, U. Ikeda, K. Shimada, K. Ozawa, et al. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase PNAS, October 12, 1999; 96(21): 11976 - 11981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Lafont, F. Ottones, J. Liautard, and J. Favero Evidence for a p21ras/Raf-1/MEK-1/ERK-2-independent Pathway in Stimulation of IL-2 Gene Transcription in Human Primary T Lymphocytes J. Biol. Chem., September 3, 1999; 274(36): 25743 - 25748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Harada, E. Tanabe, R. Watanabe, B. D. Weiss, A. Matsumoto, H. Ariga, O. Koiwai, Y. Fukui, M. Kubo, C. H. June, et al. Novel Role of Phosphatidylinositol 3-Kinase in CD28-mediated Costimulation J. Biol. Chem., March 16, 2001; 276(12): 9003 - 9008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yoshida, Y. Yamashita, A. Miyazato, K.-i. Ohya, A. Kitanaka, U. Ikeda, K. Shimada, T. Yamanaka, K. Ozawa, and H. Mano Mediation by the Protein-tyrosine Kinase Tec of Signaling between the B Cell Antigen Receptor and Dok-1 J. Biol. Chem., August 4, 2000; 275(32): 24945 - 24952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Sylla, K. Murphy, E. Cahir-McFarland, W. S. Lane, G. Mosialos, and E. Kieff The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B PNAS, June 20, 2000; 97(13): 7470 - 7475. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
