| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 2, 638-648, January 8, 1999
From the Division of Molecular Biology and Biochemistry, School of
Biological Sciences, University of Missouri-Kansas City,
Kansas City, Missouri 64110-2499
Hemopexin protects cells lacking hemopexin
receptors by tightly binding heme abrogating its deleterious effects
and preventing nonspecific heme uptake, whereas cells with hemopexin
receptors undergo a series of cellular events upon encountering
heme-hemopexin. The biochemical responses to heme-hemopexin depend on
its extracellular concentration and range from stimulation of cell
growth at low levels to cell survival at otherwise toxic levels of
heme. High (2-10 µM) but not low (0.01-1
µM) concentrations of heme-hemopexin increase, albeit
transiently, the protein carbonyl content of mouse hepatoma (Hepa)
cells. This is due to events associated with heme transport since
cobalt-protoporphyrin IX-hemopexin, which binds to the receptor and
activates signaling pathways without tetrapyrrole transport, does not
increase carbonyl content. The N-terminal c-Jun kinase (JNK) is rapidly
activated by 2-10 µM heme-hemopexin, yet the increased
intracellular heme levels are neither toxic nor apoptotic. After
24 h exposure to 10 µM heme-hemopexin, Hepa cells
become refractory to the growth stimulation seen with 0.1-0.75
µM heme-hemopexin but HO-1 remains responsive to
induction by heme-hemopexin. Since free heme does not induce JNK, the
signaling events, like phosphorylation of c-Jun via activation of JNK
as well as the nuclear translocation of NF
B, G2/M
arrest, and increased expression of p53 and of the cell cycle inhibitor
p21WAF1/CIP1/SDI1 generated by heme-hemopexin appear to be of
paramount importance in cellular protection by heme-hemopexin.
This article has been cited by other articles:
|
|
 |
|
  J. C. Mocny, J. S. Olson, and T. D. Connell Passively Released Heme from Hemoglobin and Myoglobin Is a Potential Source of Nutrient Iron for Bordetella bronchiseptica Infect. Immun., October 1, 2007; 75(10): 4857 - 4866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Korrapati, J. Chilakapati, F. A. Witzmann, C. Rao, E. A. Lock, and H. M. Mehendale Proteomics of S-(1, 2-dichlorovinyl)-L-cysteine-induced acute renal failure and autoprotection in mice Am J Physiol Renal Physiol, October 1, 2007; 293(4): F994 - F1006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. D. T. G. Wagener, H. E. van Beurden, J. W. von den Hoff, G. J. Adema, and C. G. Figdor The heme-heme oxygenase system: a molecular switch in wound healing Blood, July 15, 2003; 102(2): 521 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. N. J. Strube, J. L. Beard, and A. C. Ross Iron Deficiency and Marginal Vitamin A Deficiency Affect Growth, Hematological Indices and the Regulation of Iron Metabolism Genes in Rats J. Nutr., December 1, 2002; 132(12): 3607 - 3615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tolosano, S. Fagoonee, E. Hirsch, F. G. Berger, H. Baumann, L. Silengo, and F. Altruda Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis Blood, December 1, 2002; 100(12): 4201 - 4208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Chae, S. W. Chae, J. S. Kang, B. G. Bang, S. B. Cho, R. K. Park, H. S. So, Y. K. Kim, H. M. Kim, and H. R. Kim Dexamethasone Suppresses Tumor Necrosis Factor-{alpha}-Induced Apoptosis in Osteoblasts: Possible Role for Ceramide Endocrinology, August 1, 2000; 141(8): 2904 - 2913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balla, G. Balla, V. Jeney, G. Kakuk, H. S. Jacob, and G. M. Vercellotti Ferriporphyrins and endothelium: a 2-edged sword---promotion of oxidation and induction of cytoprotectants Blood, June 1, 2000; 95(11): 3442 - 3450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tolosano, E. Hirsch, E. Patrucco, C. Camaschella, R. Navone, L. Silengo, and F. Altruda Defective Recovery and Severe Renal Damage After Acute Hemolysis in Hemopexin-Deficient Mice Blood, December 1, 1999; 94(11): 3906 - 3914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Maya-Monteiro, S. Daffre, C. Logullo, F. A. Lara, E. W. Alves, M. L. Capurro, R. Zingali, I. C. Almeida, and P. L. Oliveira HeLp, a Heme Lipoprotein from the Hemolymph of the Cattle Tick, Boophilus microplus J. Biol. Chem., November 17, 2000; 275(47): 36584 - 36589. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
