|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 20, 13870-13876, May 14, 1999
From the We have previously shown that early growth
response (Egr) 1-deficient mice exhibit female infertility,
reflecting a luteinizing hormone (LH)
Activation of Luteinizing Hormone
Gene by
Gonadotropin-releasing Hormone Requires the Synergy of Early Growth
Response-1 and Steroidogenic Factor-1
,,¶
Department of Obstetrics and Gynecology, the
§ Department of Pathology, and the ¶ Department of Cell
Biology and Physiology, Washington University School of Medicine,
St. Louis, Missouri 63110
deficiency. Egr-1
activates the LH gene in vitro through synergy with
steroidogenic factor-1 (SF-1), a protein required for gonadotrope
function. To test if this synergy is essential for
gonadotropin-releasing hormone (GnRH) stimulation of LH, we examined
the activity of the LH promoter in the gonadotrope cell line LT2.
GnRH markedly stimulated the LH promoter (15-fold). Mutation of
either Egr-1 or SF-1 elements within the LH promoter attenuated this
stimulation, whereas mutation of both promoter elements abrogated GnRH
induction of the LH promoter. Furthermore, GnRH stimulated Egr-1 but
not SF-1 expression in LT2 cells. Importantly, overexpression of
Egr-1 alone was sufficient to enhance LH expression. Although other
Egr proteins are expressed in LT2 cells and are capable of
interacting with SF-1, GnRH stimulation of Egr-1 was the most robust.
We also found that the nuclear receptor DAX-1, a repressor of SF-1
activity, reduced Egr-1-SF-1 synergy and diminished GnRH stimulation
of the LH promoter. We conclude that the synergy between Egr-1 and
SF-1 is essential for GnRH stimulation of the LH gene and plays
a central role in the dynamic regulation of LH expression.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. P. Bliss, A. Miller, A. M. Navratil, J. Xie, S. P. McDonough, P. J. Fisher, G. E. Landreth, and M. S. Roberson ERK Signaling in the Pituitary Is Required for Female But Not Male Fertility Mol. Endocrinol., July 1, 2009; 23(7): 1092 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F Nogueira, Y. Xing, C. A V Morris, and W. E Rainey Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis J. Mol. Endocrinol., April 1, 2009; 42(4): 319 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Fustin, H. Dardente, G. C. Wagner, D. A. Carter, J. D. Johnston, G. A. Lincoln, and D. G. Hazlerigg Egr1 involvement in evening gene regulation by melatonin FASEB J, March 1, 2009; 23(3): 764 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Yang, J. H. Heaton, H. Brevig, S. Mukherjee, J. A. Iniguez-Lluhi, and G. D. Hammer SUMOylation Inhibits SF-1 Activity by Reducing CDK7-Mediated Serine 203 Phosphorylation Mol. Cell. Biol., February 1, 2009; 29(3): 613 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Walsh and M. A. Shupnik Proteasome Regulation of Dynamic Transcription Factor Occupancy on the GnRH-Stimulated Luteinizing Hormone {beta}-Subunit Promoter Mol. Endocrinol., February 1, 2009; 23(2): 237 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fortin, P. Lamba, Y. Wang, and D. J. Bernard Conservation of mechanisms mediating gonadotrophin-releasing hormone 1 stimulation of human luteinizing hormone {beta} subunit transcription Mol. Hum. Reprod., February 1, 2009; 15(2): 77 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shima, M. Zubair, T. Komatsu, S. Oka, C. Yokoyama, T. Tachibana, T. A. Hjalt, J. Drouin, and K.-i. Morohashi Pituitary Homeobox 2 Regulates Adrenal4 Binding Protein/Steroidogenic Factor-1 Gene Transcription in the Pituitary Gonadotrope through Interaction with the Intronic Enhancer Mol. Endocrinol., July 1, 2008; 22(7): 1633 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Salisbury, A. K. Binder, and J. H. Nilson Welcoming {beta}-Catenin to the Gonadotropin-Releasing Hormone Transcriptional Network in Gonadotropes Mol. Endocrinol., June 1, 2008; 22(6): 1295 - 1303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lim, M. Luo, M. Koh, M. Yang, M. N. bin Abdul Kadir, J. H. Tan, Z. Ye, W. Wang, and P. Melamed Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin {beta}-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone Mol. Cell. Biol., June 1, 2007; 27(11): 4105 - 4120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zheng, M. Jimenez-Linan, B. S. Rubin, and L. M. Halvorson Anterior Pituitary Gene Expression with Reproductive Aging in the Female Rat Biol Reprod, June 1, 2007; 76(6): 1091 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lawson, R. Tsutsumi, H. Zhang, I. Talukdar, B. K. Butler, S. J. Santos, P. L. Mellon, and N. J. G. Webster Pulse Sensitivity of the Luteinizing Hormone {beta} Promoter Is Determined by a Negative Feedback Loop Involving Early Growth Response-1 and Ngfi-A Binding Protein 1 and 2 Mol. Endocrinol., May 1, 2007; 21(5): 1175 - 1191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Maudsley, Z. Naor, D. Bonfil, L. Davidson, D. Karali, A. J. Pawson, R. Larder, C. Pope, N. Nelson, R. P. Millar, et al. Proline-Rich Tyrosine Kinase 2 Mediates Gonadotropin-Releasing Hormone Signaling to a Specific Extracellularly Regulated Kinase-Sensitive Transcriptional Locus in the Luteinizing Hormone {beta}-Subunit Gene Mol. Endocrinol., May 1, 2007; 21(5): 1216 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Salisbury, A. K. Binder, J. C. Grammer, and J. H. Nilson Maximal Activity of the Luteinizing Hormone{beta}-Subunit Gene Requires {beta}-Catenin Mol. Endocrinol., April 1, 2007; 21(4): 963 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, J. S. Bailey, D. Coss, B. Lin, R. Tsutsumi, M. A. Lawson, P. L. Mellon, and N. J. G. Webster Activin Modulates the Transcriptional Response of LssT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation Mol. Endocrinol., November 1, 2006; 20(11): 2909 - 2930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-F. Yan, E. Harja, M. Andrassy, T. Fujita, and A. M. Schmidt Protein Kinase C {beta}/Early Growth Response-1 Pathway: A Key Player in Ischemia, Atherosclerosis, and Restenosis J. Am. Coll. Cardiol., October 27, 2006; 48(9_Suppl_A): A47 - A55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ruf, M.-J. Park, F. Hayot, G. Lin, B. Roysam, Y. Ge, and S. C. Sealfon Mixed Analog/Digital Gonadotrope Biosynthetic Response to Gonadotropin-releasing Hormone J. Biol. Chem., October 13, 2006; 281(41): 30967 - 30978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Melamed, Y. Zhu, S. H. Tan, M. Xie, and M. Koh Gonadotropin-Releasing Hormone Activation of C-jun, But Not Early Growth Response Factor-1, Stimulates Transcription of a Luteinizing Hormone {beta}-Subunit Gene Endocrinology, July 1, 2006; 147(7): 3598 - 3605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Luo, M. Koh, J. Feng, Q. Wu, and P. Melamed Cross Talk in Hormonally Regulated Gene Transcription through Induction of Estrogen Receptor Ubiquitylation Mol. Cell. Biol., August 15, 2005; 25(16): 7386 - 7398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Jiang, K.-H. Jeong, C. D Horton, and L. M Halvorson Pituitary homeobox 1 (Pitx1) stimulates rat LH{beta} gene expression via two functional DNA-regulatory regions J. Mol. Endocrinol., August 1, 2005; 35(1): 145 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Simard, M.-L. Ricketts, S. Gingras, P. Soucy, F. A. Feltus, and M. H. Melner Molecular Biology of the 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 Isomerase Gene Family Endocr. Rev., June 1, 2005; 26(4): 525 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Komatsu, H. Mizusaki, T. Mukai, H. Ogawa, D. Baba, M. Shirakawa, S. Hatakeyama, K. I. Nakayama, H. Yamamoto, A. Kikuchi, et al. Small Ubiquitin-Like Modifier 1 (SUMO-1) Modification of the Synergy Control Motif of Ad4 Binding Protein/Steroidogenic Factor 1 (Ad4BP/SF-1) Regulates Synergistic Transcription between Ad4BP/SF-1 and Sox9 Mol. Endocrinol., October 1, 2004; 18(10): 2451 - 2462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Qin, D.-m. Gao, Q.-F. Jiang, Q. Zhou, Y.-Y. Kong, Y. Wang, and Y.-H. Xie Prospero-Related Homeobox (Prox1) Is a Corepressor of Human Liver Receptor Homolog-1 and Suppresses the Transcription of the Cholesterol 7-{alpha}-Hydroxylase Gene Mol. Endocrinol., October 1, 2004; 18(10): 2424 - 2439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Jorgensen, C. C. Quirk, and J. H. Nilson Multiple and Overlapping Combinatorial Codes Orchestrate Hormonal Responsiveness and Dictate Cell-Specific Expression of the Genes Encoding Luteinizing Hormone Endocr. Rev., August 1, 2004; 25(4): 521 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Curtin, H. A. Ferris, M. Hakli, M. Gibson, O. A. Janne, J. J. Palvimo, and M. A. Shupnik Small Nuclear RING Finger Protein Stimulates the Rat Luteinizing Hormone-{beta} Promoter by Interacting with Sp1 and Steroidogenic Factor-1 and Protects from Androgen Suppression Mol. Endocrinol., May 1, 2004; 18(5): 1263 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Bernard Both SMAD2 and SMAD3 Mediate Activin-Stimulated Expression of the Follicle-Stimulating Hormone {beta} Subunit in Mouse Gonadotrope Cells Mol. Endocrinol., March 1, 2004; 18(3): 606 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Mouillet, C. Sonnenberg-Hirche, X. Yan, and Y. Sadovsky p300 Regulates the Synergy of Steroidogenic Factor-1 and Early Growth Response-1 in Activating Luteinizing Hormone-{beta} Subunit Gene J. Biol. Chem., February 27, 2004; 279(9): 7832 - 7839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamada, H. Yamamoto, T. Yonehara, H. Kanasaki, H. Nakanishi, E. Miyamoto, and K. Miyazaki Differential Activation of the Luteinizing Hormone {beta}-Subunit Promoter by Activin and Gonadotropin-Releasing Hormone: A Role for the Mitogen-Activated Protein Kinase Signaling Pathway in L{beta}T2 Gonadotrophs Biol Reprod, January 1, 2004; 70(1): 236 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ganga, H. M. Espinoza, C. J. Cox, L. Morton, T. A. Hjalt, Y. Lee, and B. A. Amendt PITX2 Isoform-specific Regulation of Atrial Natriuretic Factor Expression: SYNERGISM AND REPRESSION WITH Nkx2.5 J. Biol. Chem., June 13, 2003; 278(25): 22437 - 22445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Haisenleder, H. A. Ferris, and M. A. Shupnik The Calcium Component of Gonadotropin-Releasing Hormone-Stimulated Luteinizing Hormone Subunit Gene Transcription Is Mediated by Calcium/Calmodulin-Dependent Protein Kinase Type II Endocrinology, June 1, 2003; 144(6): 2409 - 2416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Russell, K. M. H. Doyle, I. Gonzales-Robayna, C. Pipaon, and J. S. Richards Egr-1 Induction in Rat Granulosa Cells by Follicle-Stimulating Hormone and Luteinizing Hormone: Combinatorial Regulation By Transcription Factors Cyclic Adenosine 3',5'-Monophosphate Regulatory Element Binding Protein, Serum Response Factor, Sp1, and Early Growth Response Factor-1 Mol. Endocrinol., April 1, 2003; 17(4): 520 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Raetzman, R. Ward, and S. A. Camper Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia Development, March 11, 2003; 129(18): 4229 - 4239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Johnston, S. Messager, F. J. P. Ebling, L. M. Williams, P. Barrett, and D. G. Hazlerigg Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland PNAS, March 4, 2003; 100(5): 2831 - 2835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Quirk, D. D. Seachrist, and J. H. Nilson Embryonic Expression of the Luteinizing Hormone beta Gene Appears to Be Coupled to the Transient Appearance of p8, a High Mobility Group-related Transcription Factor J. Biol. Chem., January 10, 2003; 278(3): 1680 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Scherrer, D. A. Rice, and L. L. Heckert Expression of Steroidogenic Factor 1 in the Testis Requires an Interactive Array of Elements Within Its Proximal Promoter Biol Reprod, November 1, 2002; 67(5): 1509 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Vasilyev, M. A. Lawson, D. Dipaolo, N. J. G. Webster, and P. L. Mellon Different Signaling Pathways Control Acute Induction versus Long-Term Repression of LH{beta} Transcription by GnRH Endocrinology, September 1, 2002; 143(9): 3414 - 3426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Melamed, M. Koh, P. Preklathan, L. Bei, and C. Hew Multiple Mechanisms for Pitx-1 Transactivation of a Luteinizing Hormone beta Subunit Gene J. Biol. Chem., July 12, 2002; 277(29): 26200 - 26207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Rosenberg and P. L. Mellon An Otx-Related Homeodomain Protein Binds an LH{beta} Promoter Element Important for Activation During Gonadotrope Maturation Mol. Endocrinol., June 1, 2002; 16(6): 1280 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Koskimies, J. Levallet, P. Sipila, I. Huhtaniemi, and M. Poutanen Murine Relaxin-Like Factor Promoter: Functional Characterization and Regulation by Transcription Factors Steroidogenic Factor 1 and DAX-1 Endocrinology, March 1, 2002; 143(3): 909 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Duan, M. Ito, Y. Park, E. T. Maizels, M. Hunzicker-Dunn, and J. L. Jameson GnRH Regulates Early Growth Response Protein 1 Transcription Through Multiple Promoter Elements Mol. Endocrinol., February 1, 2002; 16(2): 221 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Parker, D. A. Rice, D. S. Lala, Y. Ikeda, X. Luo, M. Wong, M. Bakke, L. Zhao, C. Frigeri, N. A. Hanley, et al. Steroidogenic Factor 1: an Essential Mediator of Endocrine Development Recent Prog. Horm. Res., January 1, 2002; 57(1): 19 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Heckert and M. D. Griswold The Expression of the Follicle-stimulating Hormone Receptor in Spermatogenesis Recent Prog. Horm. Res., January 1, 2002; 57(1): 129 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Wurmbach, T. Yuen, B. J. Ebersole, and S. C. Sealfon Gonadotropin-releasing Hormone Receptor-coupled Gene Network Organization J. Biol. Chem., December 7, 2001; 276(50): 47195 - 47201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zhang, M. W. Wolfe, and M. S. Roberson An Early Growth Response Protein (Egr) 1 cis-Element Is Required for Gonadotropin-releasing Hormone-induced Mitogen-activated Protein Kinase Phosphatase 2 Gene Expression J. Biol. Chem., November 30, 2001; 276(49): 45604 - 45613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Curtin, S. Jenkins, N. Farmer, A. C. Anderson, D. J. Haisenleder, E. Rissman, E. M. Wilson, and M. A. Shupnik Androgen Suppression of GnRH-Stimulated Rat LH{beta} Gene Transcription Occurs Through Sp1 Sites in the Distal GnRH-Responsive Promoter Region Mol. Endocrinol., November 1, 2001; 15(11): 1906 - 1917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Jorgensen and J. H. Nilson AR Suppresses Transcription of the LH{beta} Subunit by Interacting with Steroidogenic Factor-1 Mol. Endocrinol., September 1, 2001; 15(9): 1505 - 1516. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Achermann, M. Ito, B. L. Silverman, R. L. Habiby, S. Pang, A. Rosler, and J. L. Jameson Missense Mutations Cluster within the Carboxyl-Terminal Region of DAX-1 and Impair Transcriptional Repression J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3171 - 3175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Heckert Activation of the Rat Follicle-Stimulating Hormone Receptor Promoter by Steroidogenic Factor 1 Is Blocked by Protein Kinase A and Requires Upstream Stimulatory Factor Binding to a Proximal E Box Element Mol. Endocrinol., May 1, 2001; 15(5): 704 - 715. [Abstract] [Full Text]
|
|
|
|
|
|
C. C. Quirk, K. L. Lozada, R. A. Keri, and J. H. Nilson A Single Pitx1 Binding Site Is Essential for Activity of the LH{beta} Promoter in Transgenic Mice Mol. Endocrinol., May 1, 2001; 15(5): 734 - 746. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. Tremblay and R. S. Viger Nuclear Receptor Dax-1 Represses the Transcriptional Cooperation Between GATA-4 and SF-1 in Sertoli Cells Biol Reprod, April 1, 2001; 64(4): 1191 - 1199. [Abstract] [Full Text]
|
|
|
|
 |
|
 C.H. Nilsson, M. Kaleva, H. Virtanen, A.M. Haavisto, K. Pettersson, and I.T. Huhtaniemi Disparate response of wild-type and variant forms of LH to GnRH stimulation in individuals heterozygous for the LH{beta} variant allele Hum. Reprod., February 1, 2001; 16(2): 230 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ou, J.-F. Mouillet, X. Yan, C. Dorn, P. A. Crawford, and Y. Sadovsky The DEAD Box Protein DP103 Is a Regulator of Steroidogenic Factor-1 Mol. Endocrinol., January 1, 2001; 15(1): 69 - 79. [Abstract] [Full Text]
|
|
|
|
|
|
S. Wolfahrt, B. Kleine, H. Jarry, and W. G. Rossmanith Endogenous regulation of the GnRH receptor by GnRH in the human placenta Mol. Hum. Reprod., January 1, 2001; 7(1): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Zhao, M Bakke, Y Krimkevich, L. Cushman, A. Parlow, S. Camper, and K. Parker Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function Development, January 1, 2001; 128(2): 147 - 154. [Abstract] [PDF]
|
|
|
|
|
|
M. Higa, H. Kanda, T. Kitahashi, M. Ito, T. Shiba, and H. Ando Quantitative Analysis of fushi tarazu Factor 1 Homolog Messenger Ribonucleic Acids in the Pituitary of Salmon at Different Prespawning Stages Biol Reprod, December 1, 2000; 63(6): 1756 - 1763. [Abstract] [Full Text]
|
|
|
|
|
|
U. B. Kaiser, L. M. Halvorson, and M. T. Chen Sp1, Steroidogenic Factor 1 (SF-1), and Early Growth Response Protein 1 (Egr-1) Binding Sites Form a Tripartite Gonadotropin-Releasing Hormone Response Element in the Rat Luteinizing Hormone-{beta} Gene Promoter: an Integral Role for SF-1 Mol. Endocrinol., August 1, 2000; 14(8): 1235 - 1245. [Abstract] [Full Text]
|
|
|
|
|
|
W. G. Tourtellotte, R. Nagarajan, A. Bartke, and J. Milbrandt Functional Compensation by Egr4 in Egr1-Dependent Luteinizing Hormone Regulation and Leydig Cell Steroidogenesis Mol. Cell. Biol., July 15, 2000; 20(14): 5261 - 5268. [Abstract] [Full Text]
|
|
|
|
|
|
L. L. Espey, T. Ujioka, D. L. Russell, M. Skelsey, B. Vladu, R. L. Robker, H. Okamura, and J. S. Richards Induction of Early Growth Response Protein-1 Gene Expression in the Rat Ovary in Response to an Ovulatory Dose of Human Chorionic Gonadotropin Endocrinology, July 1, 2000; 141(7): 2385 - 2391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Keri, D. J. Bachmann, A. Behrooz, B. D. Herr, R. K. Ameduri, C. C. Quirk, and J. H. Nilson An NF-Y Binding Site Is Important for Basal, but Not Gonadotropin-releasing Hormone-stimulated, Expression of the Luteinizing Hormone beta Subunit Gene J. Biol. Chem., April 21, 2000; 275(17): 13082 - 13088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Weck, A. C. Anderson, S. Jenkins, P. C. Fallest, and M. A. Shupnik Divergent and Composite Gonadotropin-Releasing Hormone-Responsive Elements in the Rat Luteinizing Hormone Subunit Genes Mol. Endocrinol., April 1, 2000; 14(4): 472 - 485. [Abstract] [Full Text]
|
|
|
|
|
|
B. R. Sevetson, J. Svaren, and J. Milbrandt A Novel Activation Function for NAB Proteins in EGR-dependent Transcription of the Luteinizing Hormone beta Gene J. Biol. Chem., March 24, 2000; 275(13): 9749 - 9757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Barnea and Y. Bergman Synergy of SF1 and RAR in Activation of Oct-3/4 Promoter J. Biol. Chem., February 25, 2000; 275(9): 6608 - 6619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ito, Y. Park, J. Weck, K. E. Mayo, and J. L. Jameson Synergistic Activation of the Inhibin {alpha}-Promoter by Steroidogenic Factor-1 and Cyclic Adenosine 3',5'-Monophosphate Mol. Endocrinol., January 1, 2000; 14(1): 66 - 81. [Abstract] [Full Text]
|
|
|
|
|
|
M. W. Wolfe The Equine Luteinizing Hormone {beta}-Subunit Promoter Contains Two Functional Steroidogenic Factor-1 Response Elements Mol. Endocrinol., September 1, 1999; 13(9): 1497 - 1510. [Abstract] [Full Text]
|
|
|
|
|
|
T. Yokoi, M. Ohmichi, K. Tasaka, A. Kimura, Y. Kanda, J. Hayakawa, M. Tahara, K. Hisamoto, H. Kurachi, and Y. Murata Activation of the Luteinizing Hormone beta Promoter by Gonadotropin-releasing Hormone Requires c-Jun NH2-terminal Protein Kinase J. Biol. Chem., July 7, 2000; 275(28): 21639 - 21647. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |