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J Biol Chem, Vol. 274, Issue 21, 14926-14935, May 21, 1999
From the Departments of Cardiovascular Research and Biophysics,
Berlex Biosciences, Richmond, California 94804
A novel cDNA has been identified from human
heart that encodes an unusual mosaic serine protease, designated corin.
Corin has a predicted structure of a type II transmembrane protein and contains two frizzled-like cysteine-rich motifs, seven low density lipoprotein receptor repeats, a macrophage scavenger receptor-like domain, and a trypsin-like protease domain in the extracellular region.
Northern analysis showed that corin mRNA was highly expressed in
the human heart. In mice, corin mRNA was detected by in
situ hybridization in the cardiac myocytes of the embryonic heart
as early as embryonic day (E) 9.5. By E11.5-13.5, corin mRNA was most abundant in the primary atrial septum and the trabecular ventricular compartment. Expression in the heart was maintained through
the adult. In addition, mouse corin mRNA was also detected in the
prehypertrophic chrondrocytes in developing bones. By fluorescent in situ hybridization analysis, the human corin gene was
mapped to 4p12-13 where a congenital heart disease locus, total
anomalous pulmonary venous return, had been previously localized. The
unique domain structure and specific embryonic expression pattern
suggest that corin may have a function in cell differentiation during development. The chromosomal localization of the human corin gene makes
it an attractive candidate gene for total anomalous pulmonary venous return.
Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel
cDNA from Human Heart
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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