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J Biol Chem, Vol. 274, Issue 22, 15301-15304, May 28, 1999
From the Institut de Génétique et de Biologie
Moléculaire et Cellulaire, CNRS/INSERM/ULP, B. P. 163-67404 Illkirch Cédex, Communauté Urbaine de
Strasbourg, France
We have investigated the expression levels of the
TATA-binding protein (TBP) and several TBP-associated factors
(TAFIIs) in differentiated adult mouse tissues.
Immunoblots performed using monoclonal antibodies show that there are
considerable variations in the levels of TBP and many TAFII
proteins present in various tissues. Consequently, the relative levels
of TAFIIs and TBP vary significantly from one tissue to
another. TBP and several TAFIIs are overexpressed in both
testis and small intestine, while in marked contrast, many of these
proteins, including TBP itself, were substantially down-regulated in
nervous tissues and in the heart. These tissues do, however, show a
high expression level of the TBP-like factor, which thus may represent
an alternative factor for the specialized transcription program in some
differentiated tissues. While there are significant variations in the
levels of TAFII28 protein, reverse transcription-coupled
polymerase chain reaction shows similar expression of the
TAFII28 mRNA in different tissues. The variations in
TAFII28 protein levels therefore result from
post-transcriptional regulatory events.
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