|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 23, 16569-16575, June 4, 1999
From the Division of Nephrology, Center for Health Sciences, UCLA
School of Medicine, Los Angeles, California 90095-1698
Previous functional studies have demonstrated
that muscle intracellular pH regulation is mediated by sodium-coupled
bicarbonate transport, Na+/H+ exchange,
and Cl
Cloning, Tissue Distribution, Genomic Organization, and
Functional Characterization of NBC3, a New Member of the Sodium
Bicarbonate Cotransporter Family
/bicarbonate exchange. We report the cloning,
sequence analysis, tissue distribution, genomic organization, and
functional analysis of a new member of the sodium bicarbonate
cotransporter (NBC) family, NBC3, from human skeletal muscle. mNBC3
encodes a 1214-residue polypeptide with 12 putative membrane-spanning
domains. The ~ 7.8-kilobase transcript is expressed uniquely in
skeletal muscle and heart. The NBC3 gene (SLC4A7) spans ~80 kb and is
composed of 25 coding exons and 24 introns that are flanked by typical splice donor and acceptor sequences. Expression of mNBC3 cRNA in
Xenopus laevis oocytes demonstrated that the protein
encodes a novel stilbene-insensitive
5-(N-ethyl-N-isopropyl)-amiloride-inhibitable sodium bicarbonate cotransporter.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  W. F. Boron, L. Chen, and M. D. Parker Modular structure of sodium-coupled bicarbonate transporters J. Exp. Biol., June 1, 2009; 212(11): 1697 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Parker, R. Musa-Aziz, J. D. Rojas, I. Choi, C. M. Daly, and W. F. Boron Characterization of Human SLC4A10 as an Electroneutral Na/HCO3 Cotransporter (NBCn2) with Cl- Self-exchange Activity J. Biol. Chem., May 9, 2008; 283(19): 12777 - 12788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Boedtkjer, J. Praetorius, E.-M. Fuchtbauer, and C. Aalkjaer Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice Am J Physiol Cell Physiol, February 1, 2008; 294(2): C591 - C603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-M. Chen, I. Choi, G. G. Haddad, and W. F. Boron Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2412 - R2420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Damkier, S. Nielsen, and J. Praetorius Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R2136 - R2146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bouyer, H. Sakai, T. Itokawa, T. Kawano, C. M. Fulton, W. F. Boron, and K. L. Insogna Colony-Stimulating Factor-1 Increases Osteoclast Intracellular pH and Promotes Survival via the Electroneutral Na/HCO3 Cotransporter NBCn1 Endocrinology, February 1, 2007; 148(2): 831 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Villa-Abrille, M. G. V. Petroff, and E. A. Aiello The electrogenic Na+/HCO3- cotransport modulates resting membrane potential and action potential duration in cat ventricular myocytes J. Physiol., February 1, 2007; 578(3): 819 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Choi, H. Soo Yang, and W. F. Boron The electrogenicity of the rat sodium-bicarbonate cotransporter NBCe1 requires interactions among transmembrane segments of the transporter J. Physiol., January 1, 2007; 578(1): 131 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, N.-Y. Koo, I.-H. Cho, T.-H. Kwon, S.-Y. Choi, S. J. Lee, S. B. Oh, J.-S. Kim, and K. Park Expression of the Na+-HCO3- cotransporter and its role in pHi regulation in guinea pig salivary glands Am J Physiol Gastrointest Liver Physiol, December 1, 2006; 291(6): G1031 - G1040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Bachmann, D. Reichelt, B. Tuo, M. P. Manns, and U. Seidler Carbachol increases Na+-HCO3- cotransport activity in murine colonic crypts in a M3-, Ca2+/calmodulin-, and PKC-dependent manner Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G650 - G657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. F. Boron Acid-Base Transport by the Renal Proximal Tubule J. Am. Soc. Nephrol., September 1, 2006; 17(9): 2368 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Boedtkjer, J. Praetorius, and C. Aalkjaer NBCn1 (slc4a7) Mediates the Na+-Dependent Bicarbonate Transport Important for Regulation of Intracellular pH in Mouse Vascular Smooth Muscle Cells Circ. Res., March 3, 2006; 98(4): 515 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pushkin and I. Kurtz SLC4 base (HCO3-, CO32-) transporters: classification, function, structure, genetic diseases, and knockout models Am J Physiol Renal Physiol, March 1, 2006; 290(3): F580 - F599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. Damkier, S. Nielsen, and J. Praetorius An anti-NH2-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H172 - H180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Abuladze, R. Azimov, D. Newman, P. Sassani, W. Liu, S. Tatishchev, A. Pushkin, and I. Kurtz Critical amino acid residues involved in the electrogenic sodium-bicarbonate cotransporter kNBC1-mediated transport J. Physiol., June 15, 2005; 565(3): 717 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Cooper, N. C. Saxena, H. S. Yang, H. J. Lee, A. G. Moring, A. Lee, and I. Choi Molecular and Functional Characterization of the Electroneutral Na/HCO3 Cotransporter NBCn1 in Rat Hippocampal Neurons J. Biol. Chem., May 6, 2005; 280(18): 17823 - 17830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamamoto, P. Swietach, A. Rossini, S.-H. Loh, R. D. Vaughan-Jones, and K. W. Spitzer Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pig J. Physiol., January 15, 2005; 562(2): 455 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ten Hove, M. G. J. Nederhoff, and C. J. A. Van Echteld Relative contributions of Na+/H+ exchange and Na+/HCO3- cotransport to ischemic Nai+ overload in isolated rat hearts Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H287 - H292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. F. Boron Regulation of intracellular pH Advan Physiol Educ, December 1, 2004; 28(4): 160 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. B. Loiselle, P. E. Morgan, B. V. Alvarez, and J. R. Casey Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA Am J Physiol Cell Physiol, June 1, 2004; 286(6): C1423 - C1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Odgaard, J. K. Jakobsen, S. Frische, J. Praetorius, S. Nielsen, C. Aalkjaer, and J. Leipziger Basolateral Na+-dependent HCO3- transporter NBCn1-mediated HCO3- influx in rat medullary thick ascending limb J. Physiol., February 15, 2004; 555(1): 205 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Platica, E. Ivan, J. F. Holland, A. Ionescu, S. Chen, J. Mandeli, P. D. Unger, and O. Platica A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells PNAS, February 10, 2004; 101(6): 1560 - 1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Kim, T.-H. Kwon, B. M. Christensen, J. Nielsen, S. M. Wall, K. M. Madsen, J. Frokiaer, and S. Nielsen Altered expression of renal acid-base transporters in rats with lithium-induced NDI Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1244 - F1257. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Wang, J. W. Meyer, M. Ashraf, and G. E. Shull Mice With a Null Mutation in the NHE1 Na+-H+ Exchanger Are Resistant to Cardiac Ischemia-Reperfusion Injury Circ. Res., October 17, 2003; 93(8): 776 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. CLAUSEN Na+-K+ Pump Regulation and Skeletal Muscle Contractility Physiol Rev, October 1, 2003; 83(4): 1269 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hirata, T. Kaneko, T. Ono, T. Nakazato, N. Furukawa, S. Hasegawa, S. Wakabayashi, M. Shigekawa, M.-H. Chang, M. F. Romero, et al. Mechanism of acid adaptation of a fish living in a pH 3.5 lake Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1199 - R1212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M Bers, W. H Barry, and S. Despa Intracellular Na+ regulation in cardiac myocytes Cardiovasc Res, March 15, 2003; 57(4): 897 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pushkin, N. Abuladze, D. Newman, V. Muronets, P. Sassani, S. Tatishchev, and I. Kurtz The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction Am J Physiol Cell Physiol, March 1, 2003; 284(3): C667 - C673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, Z. Wang, S. Barone, M. Petrovic, H. Amlal, L. Conforti, S. Petrovic, and M. Soleimani Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant Am J Physiol Renal Physiol, January 1, 2003; 284(1): F41 - F50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Park, S. B. H. Ko, J. Y. Choi, G. Muallem, P. J. Thomas, A. Pushkin, M.-S. Lee, J. Y. Kim, M. G. Lee, S. Muallem, et al. The Cystic Fibrosis Transmembrane Conductance Regulator Interacts with and Regulates the Activity of the HCO3- Salvage Transporter Human Na+-HCO3- Cotransport Isoform 3 J. Biol. Chem., December 20, 2002; 277(52): 50503 - 50509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gross and I. Kurtz Structural determinants and significance of regulation of electrogenic Na+-HCO3- cotransporter stoichiometry Am J Physiol Renal Physiol, November 1, 2002; 283(5): F876 - F887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Baetz, R. S. Haworth, M. Avkiran, and D. Feuvray The ERK pathway regulates Na+-HCO3- cotransport activity in adult rat cardiomyocytes Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H2102 - H2109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-P. Yip, S. Tsuruoka, G. J. Schwartz, and I. Kurtz Apical H+/base transporters mediating bicarbonate absorption and pHi regulation in the OMCD Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1098 - F1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Gresz, T.-H. Kwon, H. Vorum, T. Zelles, I. Kurtz, M. C. Steward, C. Aalkjaer, and S. Nielsen Immunolocalization of electroneutral Na+-HCO3- cotransporters in human and rat salivary glands Am J Physiol Gastrointest Liver Physiol, August 1, 2002; 283(2): G473 - G480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sassani, A. Pushkin, E. Gross, A. Gomer, N. Abuladze, R. Dukkipati, G. Carpenito, and I. Kurtz Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter Am J Physiol Cell Physiol, February 1, 2002; 282(2): C408 - C416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sterling, R. A. F. Reithmeier, and J. R. Casey A Transport Metabolon. FUNCTIONAL INTERACTION OF CARBONIC ANHYDRASE II AND CHLORIDE/BICARBONATE EXCHANGERS J. Biol. Chem., December 14, 2001; 276(51): 47886 - 47894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M.J Lamers Unmasking of a novel target for blocking harmful Na+ coupled acid extrusion: electrogenic Na+-HCO3- symport Cardiovasc Res, December 1, 2001; 52(3): 339 - 344. [Full Text] [PDF]
|
|
|
|
|
|
N. Khandoudi, J. Albadine, P. Robert, S. Krief, I. Berrebi-Bertrand, X. Martin, M. O Bevensee, W. F Boron, and A. Bril Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury Cardiovasc Res, December 1, 2001; 52(3): 387 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gamba Alternative splicing and diversity of renal transporters Am J Physiol Renal Physiol, November 1, 2001; 281(5): F781 - F794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bok, M. J. Schibler, A. Pushkin, P. Sassani, N. Abuladze, Z. Naser, and I. Kurtz Immunolocalization of electrogenic sodium-bicarbonate cotransporters pNBC1 and kNBC1 in the rat eye Am J Physiol Renal Physiol, November 1, 2001; 281(5): F920 - F935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Sciortino, L. D. Shrode, B. R. Fletcher, P. J. Harte, and M. F. Romero Localization of endogenous and recombinant Na+-driven anion exchanger protein NDAE1 from Drosophila melanogaster Am J Physiol Cell Physiol, August 1, 2001; 281(2): C449 - C463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhao and R. A. F. Reithmeier Expression and characterization of the anion transporter homologue YNL275w in Saccharomyces cerevisiae Am J Physiol Cell Physiol, July 1, 2001; 281(1): C33 - C45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Praetorius, H. Hager, S. Nielsen, C. Aalkjaer, U. G. Friis, M. A. Ainsworth, and T. Johansen Molecular and functional evidence for electrogenic and electroneutral Na+-HCO3{-} cotransporters in murine duodenum Am J Physiol Gastrointest Liver Physiol, March 1, 2001; 280(3): G332 - G343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Gross, N Abuladze, A Pushkin, I Kurtz, and C U Cotton The stoichiometry of the electrogenic sodium bicarbonate cotransporter pNBC1 in mouse pancreatic duct cells is 2 HCO3-:1 Na+ J. Physiol., March 1, 2001; 531(2): 375 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. MAUNSBACH, H. VORUM, T.-H. KWON, S. NIELSEN, B. SIMONSEN, I. CHOI, B. M. SCHMITT, W. F. BORON, and C. AALKJæR Immunoelectron Microscopic Localization of the Electrogenic Na/HCO3 Cotransporter in Rat and Ambystoma Kidney J. Am. Soc. Nephrol., December 1, 2000; 11(12): 2179 - 2189. [Abstract] [Full Text]
|
|
|
|
|
|
X. C. Sun, J. A. Bonanno, S. Jelamskii, and Q. Xie Expression and localization of Na+-HCO3- cotransporter in bovine corneal endothelium Am J Physiol Cell Physiol, November 1, 2000; 279(5): C1648 - C1655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Vorum, T.-H. Kwon, C. Fulton, B. Simonsen, I. Choi, W. Boron, A. B. Maunsbach, S. Nielsen, and C. Aalkjar Immunolocalization of electroneutral Na-HCO3- cotransporter in rat kidney Am J Physiol Renal Physiol, November 1, 2000; 279(5): F901 - F909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Amlal, K. Habo, and M. Soleimani Potassium deprivation upregulates expression of renal basolateral Na+-HCO3- cotransporter (NBC-1) Am J Physiol Renal Physiol, September 1, 2000; 279(3): F532 - F543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. O. Bevensee, B. M. Schmitt, I. Choi, M. F. Romero, and W. F. Boron An electrogenic Na+-HCO-3 cotransporter (NBC) with a novel COOH-terminus, cloned from rat brain Am J Physiol Cell Physiol, June 1, 2000; 278(6): C1200 - C1211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-H. Kwon, J. Frokiar, J. S. Han, M. A. Knepper, and S. Nielsen Decreased abundance of major Na+ transporters in kidneys of rats with ischemia-induced acute renal failure Am J Physiol Renal Physiol, June 1, 2000; 278(6): F925 - F939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-V. Nguyen, G. E Shull, and J. E Melvin Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice J. Physiol., February 15, 2000; 523(1): 139 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-H. Kwon, A. Pushkin, N. Abuladze, S. Nielsen, and I. Kurtz Immunoelectron microscopic localization of NBC3 sodium-bicarbonate cotransporter in rat kidney Am J Physiol Renal Physiol, February 1, 2000; 278(2): F327 - F336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Roussa, M. F. Romero, B. M. Schmitt, W. F. Boron, S. L. Alper, and F. Thevenod Immunolocalization of anion exchanger AE2 and Na+-HCO-3 cotransporter in rat parotid and submandibular glands Am J Physiol Gastrointest Liver Physiol, December 1, 1999; 277(6): G1288 - G1296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pushkin, K.-P. Yip, I. Clark, N. Abuladze, T.-H. Kwon, S. Tsuruoka, G. J. Schwartz, S. Nielsen, and I. Kurtz NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase Am J Physiol Renal Physiol, December 1, 1999; 277(6): F974 - F981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Z. Wang, H. Yano, K. Nagashima, and S. Seino The Na+-driven Cl-/HCO3- Exchanger. CLONING, TISSUE DISTRIBUTION, AND FUNCTIONAL CHARACTERIZATION J. Biol. Chem., November 3, 2000; 275(45): 35486 - 35490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. I Grichtchenko, I. Choi, X. Zhong, P. Bray-Ward, J. M. Russell, and W. F. Boron Cloning, Characterization, and Chromosomal Mapping of a Human Electroneutral Na+-driven Cl-HCO3 Exchanger J. Biol. Chem., March 9, 2001; 276(11): 8358 - 8363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Romero, D. Henry, S. Nelson, P. J. Harte, A. K. Dillon, and C. M. Sciortino Cloning and Characterization of a Na+-driven Anion Exchanger (NDAE1). A NEW BICARBONATE TRANSPORTER J. Biol. Chem., August 4, 2000; 275(32): 24552 - 24559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tsuganezawa, K. Kobayashi, M. Iyori, T. Araki, A. Koizumi, S.-I. Watanabe, A. Kaneko, T. Fukao, T. Monkawa, T. Yoshida, et al. A New Member of the HCO3- Transporter Superfamily Is an Apical Anion Exchanger of beta -Intercalated Cells in the Kidney J. Biol. Chem., March 9, 2001; 276(11): 8180 - 8189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Luo, J. Y. Choi, S. B. H. Ko, A. Pushkin, I. Kurtz, W. Ahn, M. G. Lee, and S. Muallem HCO3- Salvage Mechanisms in the Submandibular Gland Acinar and Duct Cells J. Biol. Chem., March 23, 2001; 276(13): 9808 - 9816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. V. Virkki, D. A. Wilson, R. D. Vaughan-Jones, and W. F. Boron Functional characterization of human NBC4 as an electrogenic Na+-HCO3- cotransporter (NBCe2) Am J Physiol Cell Physiol, June 1, 2002; 282(6): C1278 - C1289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-H. Kwon, C. Fulton, W. Wang, I. Kurtz, J. Frokiar, C. Aalkjar, and S. Nielsen Chronic metabolic acidosis upregulates rat kidney Na-HCO3- cotransporters NBCn1 and NBC3 but not NBC1 Am J Physiol Renal Physiol, February 1, 2002; 282(2): F341 - F351. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |