| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 24, 16677-16680, June 11, 1999
From the Department of Physiological Chemistry, Graduate School of
Pharmaceutical Sciences, University of Tokyo,
Tokyo 113-0033, Japan
The mammalian GTP-binding protein GSPT, whose
carboxyl-terminal sequence is homologous to the eukaryotic elongation
factor EF1
, binds to the polypeptide chain releasing factor eRF1 to function as eRF3 in the translation termination. The amino-terminal domain of GSPT was, however, not required for the binding. Search for
other GSPT-binding proteins in yeast two-hybrid screening system
resulted in the identification of a cDNA encoding
polyadenylate-binding protein (PABP), whose amino terminus is
associating with the poly(A) tail of mRNAs presumably for their
stabilization. The interaction appeared to be mediated through the
carboxyl-terminal domain of PABP and the amino-terminal region of GSPT.
Interestingly, multimerization of PABP with poly(A), which is ascribed
to the action of its carboxyl-terminal domain, was completely inhibited
by the interaction with the amino-terminal domain of GSPT. These
results indicate that GSPT/eRF3 may play important roles not only in
the termination of protein synthesis but also in the regulation of
mRNA stability. Thus, the present study is the first report
showing that GSPT/eRF3 carries the translation termination signal to
3'-poly(A) tail ubiquitously present in eukaryotic mRNAs.
This article has been cited by other articles:
|
|
 |
|
  A. L. Silva, P. Ribeiro, A. Inacio, S. A. Liebhaber, and L. Romao Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay RNA, March 1, 2008; 14(3): 563 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Funakoshi, Y. Doi, N. Hosoda, N. Uchida, M. Osawa, I. Shimada, M. Tsujimoto, T. Suzuki, T. Katada, and S.-i. Hoshino Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases Genes & Dev., December 1, 2007; 21(23): 3135 - 3148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fang, M. Menon, W. Kapelle, O. Bogacheva, O. Bogachev, E. Houde, S. Browne, P. Sathyanarayana, and D. M. Wojchowski EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts Blood, October 1, 2007; 110(7): 2361 - 2370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Bradrick, E. Y. Dobrikova, C. Kaiser, M. Shveygert, and M. Gromeier Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosome entry sites RNA, September 1, 2007; 13(9): 1582 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Yao, Y.-C. Chiang, C. Zhang, D. J. Lee, T. M. Laue, and C. L. Denis PAB1 Self-Association Precludes Its Binding to Poly(A), Thereby Accelerating CCR4 Deadenylation In Vivo Mol. Cell. Biol., September 1, 2007; 27(17): 6243 - 6253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chauvin, S. Salhi, and O. Jean-Jean Human Eukaryotic Release Factor 3a Depletion Causes Cell Cycle Arrest at G1 Phase through Inhibition of the mTOR Pathway Mol. Cell. Biol., August 15, 2007; 27(16): 5619 - 5629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Keeling, J. Salas-Marco, L. Z. Osherovich, and D. M. Bedwell Tpa1p Is Part of an mRNP Complex That Influences Translation Termination, mRNA Deadenylation, and mRNA Turnover in Saccharomyces cerevisiae. Mol. Cell. Biol., July 1, 2006; 26(14): 5237 - 5248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hosoda, F. Lejeune, and L. E. Maquat Evidence that Poly(A) Binding Protein C1 Binds Nuclear Pre-mRNA Poly(A) Tails Mol. Cell. Biol., April 15, 2006; 26(8): 3085 - 3097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mehta, C. R. Trotta, and S. W. Peltz Derepression of the Her-2 uORF is mediated by a novel post-transcriptional control mechanism in cancer cells Genes & Dev., April 15, 2006; 20(8): 939 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Bradrick, R. W. Walters, and M. Gromeier The hepatitis C virus 3'-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase Nucleic Acids Res., March 1, 2006; 34(4): 1293 - 1303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chauvin, S. Salhi, C. Le Goff, W. Viranaicken, D. Diop, and O. Jean-Jean Involvement of Human Release Factors eRF3a and eRF3b in Translation Termination and Regulation of the Termination Complex Formation Mol. Cell. Biol., July 15, 2005; 25(14): 5801 - 5811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Malta-Vacas, C Aires, P Costa, A R Conde, S Ramos, A P Martins, C Monteiro, and M Brito Differential expression of the eukaryotic release factor 3 (eRF3/GSPT1) according to gastric cancer histological types J. Clin. Pathol., June 1, 2005; 58(6): 621 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Wilkie, P. Gautier, D. Lawson, and N. K. Gray Embryonic Poly(A)-Binding Protein Stimulates Translation in Germ Cells Mol. Cell. Biol., March 1, 2005; 25(5): 2060 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Okochi, T. Suzuki, J.-i. Inoue, S. Matsuda, and T. Yamamoto Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control Genes Cells, February 1, 2005; 10(2): 151 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kobayashi, Y. Funakoshi, S.-i. Hoshino, and T. Katada The GTP-binding Release Factor eRF3 as a Key Mediator Coupling Translation Termination to mRNA Decay J. Biol. Chem., October 29, 2004; 279(44): 45693 - 45700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Janzen and A. P. Geballe The effect of eukaryotic release factor depletion on translation termination in human cell lines Nucleic Acids Res., August 23, 2004; 32(15): 4491 - 4502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-C. Chang, A. Yamashita, C.-Y. A. Chen, Y. Yamashita, W. Zhu, S. Durdan, A. Kahvejian, N. Sonenberg, and A.-B. Shyu UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant Genes & Dev., August 15, 2004; 18(16): 2010 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kuyumcu-Martinez, G. Belliot, S. V. Sosnovtsev, K.-O. Chang, K. Y. Green, and R. E. Lloyd Calicivirus 3C-Like Proteinase Inhibits Cellular Translation by Cleavage of Poly(A)-Binding Protein J. Virol., August 1, 2004; 78(15): 8172 - 8182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Kuyumcu-Martinez, M. E. Van Eden, P. Younan, and R. E. Lloyd Cleavage of Poly(A)-Binding Protein by Poliovirus 3C Protease Inhibits Host Cell Translation: a Novel Mechanism for Host Translation Shutoff Mol. Cell. Biol., February 15, 2004; 24(4): 1779 - 1790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Uchida, S.-i. Hoshino, and T. Katada Identification of a Human Cytoplasmic Poly(A) Nuclease Complex Stimulated by Poly(A)-binding Protein J. Biol. Chem., January 9, 2004; 279(2): 1383 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Burgui, T. Aragon, J. Ortin, and A. Nieto PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes J. Gen. Virol., December 1, 2003; 84(12): 3263 - 3274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Melo, R. Dhalia, C. M. de Sa, N. Standart, and O. P. de Melo Neto Identification of a C-terminal Poly(A)-binding Protein (PABP)-PABP Interaction Domain: ROLE IN COOPERATIVE BINDING TO POLY(A) AND EFFICIENT CAP DISTAL TRANSLATIONAL REPRESSION J. Biol. Chem., November 21, 2003; 278(47): 46357 - 46368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kajiho, K. Saito, K. Tsujita, K. Kontani, Y. Araki, H. Kurosu, and T. Katada RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway J. Cell Sci., October 15, 2003; 116(20): 4159 - 4168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hosoda, T. Kobayashi, N. Uchida, Y. Funakoshi, Y. Kikuchi, S. Hoshino, and T. Katada Translation Termination Factor eRF3 Mediates mRNA Decay through the Regulation of Deadenylation J. Biol. Chem., October 3, 2003; 278(40): 38287 - 38291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. A. Chen and A.-B. Shyu Rapid Deadenylation Triggered by a Nonsense Codon Precedes Decay of the RNA Body in a Mammalian Cytoplasmic Nonsense-Mediated Decay Pathway Mol. Cell. Biol., July 15, 2003; 23(14): 4805 - 4813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Inagaki, C. Blouin, E. Susko, and A. J. Roger Assessing functional divergence in EF-1{alpha} and its paralogs in eukaryotes and archaebacteria Nucleic Acids Res., July 15, 2003; 31(14): 4227 - 4237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Belostotsky Unexpected Complexity of Poly(A)-Binding Protein Gene Families in Flowering Plants: Three Conserved Lineages That Are at Least 200 Million Years Old and Possible Auto- and Cross-Regulation Genetics, January 1, 2003; 163(1): 311 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Uchida, S.-i. Hoshino, H. Imataka, N. Sonenberg, and T. Katada A Novel Role of the Mammalian GSPT/eRF3 Associating with Poly(A)-binding Protein in Cap/Poly(A)-dependent Translation J. Biol. Chem., December 20, 2002; 277(52): 50286 - 50292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Namy, I. Hatin, G. Stahl, H. Liu, S. Barnay, L. Bidou, and J.-P. Rousset Gene Overexpression as a Tool for Identifying New trans-Acting Factors Involved in Translation Termination in Saccharomyces cerevisiae Genetics, June 1, 2002; 161(2): 585 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Cosson, A. Couturier, S. Chabelskaya, D. Kiktev, S. Inge-Vechtomov, M. Philippe, and G. Zhouravleva Poly(A)-Binding Protein Acts in Translation Termination via Eukaryotic Release Factor 3 Interaction and Does Not Influence [PSI+] Propagation Mol. Cell. Biol., May 15, 2002; 22(10): 3301 - 3315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Kuyumcu-Martinez, M. Joachims, and R. E. Lloyd Efficient Cleavage of Ribosome-Associated Poly(A)-Binding Protein by Enterovirus 3C Protease J. Virol., March 1, 2002; 76(5): 2062 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mazumder, V. Seshadri, H. Imataka, N. Sonenberg, and P. L. Fox Translational Silencing of Ceruloplasmin Requires the Essential Elements of mRNA Circularization: Poly(A) Tail, Poly(A)-Binding Protein, and Eukaryotic Translation Initiation Factor 4G Mol. Cell. Biol., October 1, 2001; 21(19): 6440 - 6449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Khaleghpour, A. Kahvejian, G. De Crescenzo, G. Roy, Y. V. Svitkin, H. Imataka, M. O'Connor-McCourt, and N. Sonenberg Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein Mol. Cell. Biol., August 1, 2001; 21(15): 5200 - 5213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kozlov, J.-F. Trempe, K. Khaleghpour, A. Kahvejian, I. Ekiel, and K. Gehring Structure and function of the C-terminal PABC domain of human poly(A)-binding protein PNAS, March 29, 2001; (2001) 71024998. [Abstract] [Full Text]
|
|
|
|
|
|
R. C. Deo, N. Sonenberg, and S. K. Burley X-ray structure of the human hyperplastic discs protein: An ortholog of the C-terminal domain of poly(A)-binding protein PNAS, March 29, 2001; (2001) 71552198. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Bertram, S. Innes, O. Minella, J. P. Richardson, and I. Stansfield Endless possibilities: translation termination and stop codon recognition Microbiology, February 1, 2001; 147(2): 255 - 269. [Full Text]
|
|
|
|
|
|
Z. Wang and M. Kiledjian The Poly(A)-Binding Protein and an mRNA Stability Protein Jointly Regulate an Endoribonuclease Activity Mol. Cell. Biol., September 1, 2000; 20(17): 6334 - 6341. [Abstract] [Full Text]
|
|
|
|
|
|
O. P. d. M. Neto, J. A. Walker, C. M. d. Sa, and N. Standart Levels of free PABP are limited by newly polyadenylated mRNA in early Spisula embryogenesis Nucleic Acids Res., September 1, 2000; 28(17): 3346 - 3353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Bates, E. Knuepfer, and D. F. Smith Poly(A)-binding protein I of Leishmania: functional analysis and localisation in trypanosomatid parasites Nucleic Acids Res., March 1, 2000; 28(5): 1211 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Michel, D. Poncet, M. Piron, K. M. Kean, and A. M. Borman Cap-Poly(A) Synergy in Mammalian Cell-free Extracts. INVESTIGATION OF THE REQUIREMENTS FOR POLY(A)-MEDIATED STIMULATION OF TRANSLATION INITIATION J. Biol. Chem., October 6, 2000; 275(41): 32268 - 32276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kozlov, J.-F. Trempe, K. Khaleghpour, A. Kahvejian, I. Ekiel, and K. Gehring From the Cover: Structure and function of the C-terminal PABC domain of human poly(A)-binding protein PNAS, April 10, 2001; 98(8): 4409 - 4413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Deo, N. Sonenberg, and S. K. Burley From the Cover: X-ray structure of the human hyperplastic discs protein: An ortholog of the C-terminal domain of poly(A)-binding protein PNAS, April 10, 2001; 98(8): 4414 - 4419. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
