JBC Invitrogen Ultrasensitive Cytokine Assays

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sun, X.
Right arrow Articles by Dixit, V. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sun, X.
Right arrow Articles by Dixit, V. M.

J Biol Chem, Vol. 274, Issue 24, 16871-16875, June 11, 1999

RIP3, a Novel Apoptosis-inducing Kinase

Xiaoqing SunDagger , James Lee§, Tony Navas, Daryl T. Baldwin§, Timothy A. Stewart, and Vishva M. DixitDagger

From the Dagger  Departments of Molecular Oncology, § Molecular Biology, and  Endocrine Research, Genentech, Inc., South San Francisco, California 94080

RIP3 is a novel gene product containing a N-terminal kinase domain that shares extensive homology with the corresponding domain in RIP (receptor-interacting protein) and RIP2. Unlike RIP, which has a C-terminal death domain, and RIP2, which has a C-terminal caspase activation and recruitment domain, RIP3 has a unique C terminus. RIP3 binds RIP through its unique C-terminal segment and by virtue of this interaction is recruited to the tumor necrosis factor (TNF) receptor-1 signaling complex. Previous studies have shown that RIP mediates TNF-induced activation of the anti-apoptotic NF-kappa B pathway. RIP3, however, attenuates both RIP and TNF receptor-1-induced NF-kappa B activation. Overexpression studies revealed RIP3 to be a potent inducer of apoptosis, capable of selectively binding to large prodomain initiator caspases.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.


This article has been cited by other articles:


Home page
 BloodHome page
J. R. Cerhan, S. M. Ansell, Z. S. Fredericksen, N. E. Kay, M. Liebow, T. G. Call, A. Dogan, J. M. Cunningham, A. H. Wang, W. Liu-Mares, et al.
Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma
Blood, December 15, 2007; 110(13): 4455 - 4463.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Shu, S. Lv, Y. Qin, X. Ma, X. Wang, X. Peng, Y. Luo, B.-e Xu, X. Sun, and J. Wu
Functional characterization of human PFTK1 as a cyclin-dependent kinase
PNAS, May 29, 2007; 104(22): 9248 - 9253.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. J. Kaiser and M. K. Offermann
Apoptosis Induced by the Toll-Like Receptor Adaptor TRIF Is Dependent on Its Receptor Interacting Protein Homotypic Interaction Motif
J. Immunol., April 15, 2005; 174(8): 4942 - 4952.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L. Li, L.-H. Bin, F. Li, Y. Liu, D. Chen, Z. Zhai, and H.-B. Shu
TRIP6 is a RIP2-associated common signaling component of multiple NF-{kappa}B activation pathways
J. Cell Sci., February 1, 2005; 118(3): 555 - 563.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Yang, J. Ma, Y. Chen, and M. Wu
Nucleocytoplasmic Shuttling of Receptor-interacting Protein 3 (RIP3): IDENTIFICATION OF NOVEL NUCLEAR EXPORT AND IMPORT SIGNALS IN RIP3
J. Biol. Chem., September 10, 2004; 279(37): 38820 - 38829.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Z. Song, S. Liu, H. He, N. Hoti, Y. Wang, S. Feng, and M. Wu
A Single Amino Acid Change (Asp 53-> Ala53) Converts Survivin from Anti-apoptotic to Pro-apoptotic
Mol. Biol. Cell, March 1, 2004; 15(3): 1287 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Newton, X. Sun, and V. M. Dixit
Kinase RIP3 Is Dispensable for Normal NF-{kappa}Bs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4
Mol. Cell. Biol., February 15, 2004; 24(4): 1464 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. T. Moran, K. Haider, Y. Ow, P. Milton, L. Chen, and S. Pillai
Protein Kinase C-associated Kinase Can Activate NF{kappa}B in Both a Kinase-dependent and a Kinase-independent Manner
J. Biol. Chem., June 6, 2003; 278(24): 21526 - 21533.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. Kaynak, A. von Heydebreck, S. Mebus, D. Seelow, S. Hennig, J. Vogel, H.-P. Sperling, R. Pregla, V. Alexi-Meskishvili, R. Hetzer, et al.
Genome-Wide Array Analysis of Normal and Malformed Human Hearts
Circulation, May 20, 2003; 107(19): 2467 - 2474.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Muto, J. Ruland, L. M. McAllister-Lucas, P. C. Lucas, S. Yamaoka, F. F. Chen, A. Lin, T. W. Mak, G. Nunez, and N. Inohara
Protein Kinase C-associated Kinase (PKK) Mediates Bcl10-independent NF-kappa B Activation Induced by Phorbol Ester
J. Biol. Chem., August 23, 2002; 277(35): 31871 - 31876.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Munz, E. Hildt, M. L. Springer, and H. M. Blau
RIP2, a Checkpoint in Myogenic Differentiation
Mol. Cell. Biol., August 15, 2002; 22(16): 5879 - 5886.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Sun, J. Yin, M. A. Starovasnik, W. J. Fairbrother, and V. M. Dixit
Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3
J. Biol. Chem., March 8, 2002; 277(11): 9505 - 9511.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Dan, S.-E. Ong, N. M. Watanabe, B. Blagoev, M. M. Nielsen, E. Kajikawa, T. Z. Kristiansen, M. Mann, and A. Pandey
Cloning of MASK, a Novel Member of the Mammalian Germinal Center Kinase III Subfamily, with Apoptosis-inducing Properties
J. Biol. Chem., February 15, 2002; 277(8): 5929 - 5939.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
B. B Aggarwal
Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappa B
Ann Rheum Dis, November 1, 2000; 59(90001): i6 - 16.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Inbal, G. Shani, O. Cohen, J. L. Kissil, and A. Kimchi
Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis
Mol. Cell. Biol., February 1, 2000; 20(3): 1044 - 1054.
[Abstract] [Full Text]

Home page
 Cardiovasc ResHome page
M. J.B van den Hoff, S. M van den Eijnde, S. Viragh, and A. F.M Moorman
Programmed cell death in the developing heart
Cardiovasc Res, February 1, 2000; 45(3): 603 - 620.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. M. Kasof and B. C. Gomes
Livin, a Novel Inhibitor of Apoptosis Protein Family Member
J. Biol. Chem., January 26, 2001; 276(5): 3238 - 3246.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Araki, R. Nagarajan, and J. Milbrandt
Identification of Genes Induced in Peripheral Nerve after Injury. EXPRESSION PROFILING AND NOVEL GENE DISCOVERY
J. Biol. Chem., August 31, 2001; 276(36): 34131 - 34141.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1999 by the American Society for Biochemistry and Molecular Biology.