| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 24, 16965-16972, June 11, 1999
From the Department of Internal Medicine, University of Turin,
Turin 10126, Italy and the § Department of Biological
Regulation, Weizmann Institute of Science, 76100 Rehovot, Israel
Stem cell factor (SCF) and its tyrosine kinase
receptor, c-Kit, play a crucial role in regulating migration and
proliferation of melanoblasts, germ cells, and hemopoietic cell
progenitors by activating a number of intracellular signaling
molecules. Here we report that SCF stimulation of myeloid cells or
fibroblasts ectopically expressing c-Kit induces physical association
with and tyrosine phosphorylation of three signal transducers and
activators of transcription (STATs) as follows: STAT1
, STAT5A, and
STAT5B. Other STAT proteins are not recruited upon SCF stimulation.
Recruitment of STATs leads to their dimerization, nuclear
translocation, and binding to specific promoter-responsive elements.
Whereas STAT1, possibly in the form of homodimers, binds to the
sis-inducible DNA element, STAT5 proteins, either as
STAT5A/STAT5B or STAT5/STAT1 heterodimers, bind to the
prolactin-inducible element of the 
-casein promoter. The tyrosine
kinase activity of Kit appears essential for STAT activation since a
kinase-defective mutant lacking a kinase insert domain was inactive in
STAT signaling. However, another mutant that lacked the
carboxyl-terminal region retained STAT1 activation and nuclear
translocation but was unable to fully activate STAT5 proteins, although
it mediated their transient phosphorylation. These results indicate
that different intracellular domains of c-Kit are involved in
activation of the various STAT proteins.
This article has been cited by other articles:
|
|
 |
|
  T. Jahn, S. Sindhu, S. Gooch, P. Seipel, P. Lavori, E. Leifheit, and K. Weinberg Direct interaction between Kit and the interleukin-7 receptor Blood, September 15, 2007; 110(6): 1840 - 1847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Corbacioglu, M. Kilic, M.-A. Westhoff, D. Reinhardt, S. Fulda, and K.-M. Debatin Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin Blood, November 15, 2006; 108(10): 3504 - 3513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. O. Barnstein, G. Li, Z. Wang, S. Kennedy, C. Chalfant, H. Nakajima, K. D. Bunting, and J. J. Ryan Stat5 Expression Is Required for IgE-Mediated Mast Cell Function. J. Immunol., September 1, 2006; 177(5): 3421 - 3426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Maertens, H. Prenen, M. Debiec-Rychter, A. Wozniak, R. Sciot, P. Pauwels, I. De Wever, J. R. Vermeesch, T. de Raedt, A. De Paepe, et al. Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients Hum. Mol. Genet., March 15, 2006; 15(6): 1015 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. P. Li, J. A. Fletcher, M. C. Heinrich, J. E. Garber, S. E. Sallan, C. Curiel-Lewandrowski, A. Duensing, M. van de Rijn, L. E. Schnipper, and G. D. Demetri Familial Gastrointestinal Stromal Tumor Syndrome: Phenotypic and Molecular Features in a Kindred J. Clin. Oncol., April 20, 2005; 23(12): 2735 - 2743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Kataoka, N. Komazawa, E. Morii, K. Oboki, and T. Nakano Involvement of connective tissue-type mast cells in Th1 immune responses via Stat4 expression Blood, February 1, 2005; 105(3): 1016 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lennartsson, T. Jelacic, D. Linnekin, and R. Shivakrupa Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit Stem Cells, January 1, 2005; 23(1): 16 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Shelburne, M. E. McCoy, R. Piekorz, V. Sexl, K.-H. Roh, S. M. Jacobs-Helber, S. R. Gillespie, D. P. Bailey, P. Mirmonsef, M. N. Mann, et al. Stat5 expression is critical for mast cell development and survival Blood, August 15, 2003; 102(4): 1290 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hashimoto, I. Matsumura, T. Tsujimura, D.-K. Kim, H. Ogihara, H. Ikeda, S. Ueda, M. Mizuki, H. Sugahara, H. Shibayama, et al. Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation Blood, February 1, 2003; 101(3): 1094 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Bradley, T. S. Hawley, and K. D. Bunting Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells Blood, December 1, 2002; 100(12): 3983 - 3989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Brizzi, P. Dentelli, R. Gambino, S. Cabodi, M. Cassader, A. Castelli, P. Defilippi, L. Pegoraro, and G. Pagano STAT5 Activation Induced by Diabetic LDL Depends on LDL Glycation and Occurs Via src Kinase Activity Diabetes, November 1, 2002; 51(11): 3311 - 3317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Bunting, H. L. Bradley, T. S. Hawley, R. Moriggl, B. P. Sorrentino, and J. N. Ihle Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5 Blood, January 15, 2002; 99(2): 479 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chian, S. Young, A. Danilkovitch-Miagkova, L. Ronnstrand, E. Leonard, P. Ferrao, L. Ashman, and D. Linnekin Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant Blood, September 1, 2001; 98(5): 1365 - 1373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Duarte and D. A. Frank SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways Blood, November 15, 2000; 96(10): 3422 - 3430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Pang, S. Fagerlie, T. A. Christianson, W. Keeble, G. Faulkner, J. Diaz, R. K. Rathbun, and G. C. Bagby The Fanconi Anemia Protein FANCC Binds to and Facilitates the Activation of STAT1 by Gamma Interferon and Hematopoietic Growth Factors Mol. Cell. Biol., July 1, 2000; 20(13): 4724 - 4735. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
