|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 24, 16973-16978, June 11, 1999
From the The early phase of the stimulatory effect of
aldosterone on sodium reabsorption in renal epithelia is thought to
involve activation of apical sodium channels. However, the genes
initiating this effect are unknown. We used a combination of polymerase
chain reaction-based subtractive hybridization and differential display techniques to identify aldosterone-regulated immediate early genes in
renal mineralocorticoid target cells. We report here that aldosterone rapidly increases mRNA levels of a putative Ser/Thr kinase,
sgk (or serum- and
glucocorticoid-regulated kinase), in its native target cells, i.e. in cortical collecting duct cells. The
effect occurs within 30 min of the addition of aldosterone, is mediated through mineralocorticoid receptors, and does not require de
novo protein synthesis. The full-length sequences of rabbit and
mouse sgk cDNAs were determined. Both cDNAs show
significant homology to rat and human sgk (88-94% at the
nucleotide level, and 96-99% at the amino acid level). Coexpression
of the mouse sgk in Xenopus oocytes with the
three subunits of the epithelial Na+ channel results in a
significantly enhanced Na+ current. These results suggest
that sgk is an immediate early aldosterone-induced gene,
and this protein kinase plays an important role in the early phase of
aldosterone-stimulated Na+ transport.
sgk Is an Aldosterone-induced Kinase in the Renal
Collecting Duct
EFFECTS ON EPITHELIAL Na+ CHANNELS
,,, and
Department of Physiology, Dartmouth Medical
School, Lebanon, New Hampshire 03756-0001 and ¶ Department of
Cellular and Molecular Physiology, School of Medicine, Yale University,
New Haven, Connecticut 06520
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. F. Ackermann, K. M. Boini, H. Volkl, M. Bhandaru, P. M. Bareiss, L. Just, V. Vallon, K. Amann, D. Kuhl, Y. Feng, et al. SGK1-sensitive renal tubular glucose reabsorption in diabetes Am J Physiol Renal Physiol, April 1, 2009; 296(4): F859 - F866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Li, S. Koshy, and H. G. Folkesson IL-1{beta}-induced cortisol stimulates lung fluid absorption in fetal guinea pigs via SGK-mediated Nedd4-2 inhibition Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L527 - L533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Artunc, O. Nasir, K. Amann, K. M. Boini, H.-U. Haring, T. Risler, and F. Lang Serum- and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome Am J Physiol Renal Physiol, December 1, 2008; 295(6): F1624 - F1634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Estilo, W. Liu, N. Pastor-Soler, P. Mitchell, M. D. Carattino, T. R. Kleyman, and L. M. Satlin Effect of aldosterone on BK channel expression in mammalian cortical collecting duct Am J Physiol Renal Physiol, September 1, 2008; 295(3): F780 - F788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Naray-Fejes-Toth, C. Boyd, and G. Fejes-Toth Regulation of epithelial sodium transport by promyelocytic leukemia zinc finger protein Am J Physiol Renal Physiol, July 1, 2008; 295(1): F18 - F26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fejes-Toth, G. Frindt, A. Naray-Fejes-Toth, and L. G. Palmer Epithelial Na+ channel activation and processing in mice lacking SGK1 Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1298 - F1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. McDonald A new SGK1 knockout mouse Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1296 - F1297. [Full Text] [PDF]
|
|
|
|
 |
|
 V. McEneaney, B. J. Harvey, and W. Thomas Aldosterone Regulates Rapid Trafficking of Epithelial Sodium Channel Subunits in Renal Cortical Collecting Duct Cells via Protein Kinase D Activation Mol. Endocrinol., April 1, 2008; 22(4): 881 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Terada, H. Kuwana, T. Kobayashi, T. Okado, N. Suzuki, T. Yoshimoto, Y. Hirata, and S. Sasaki Aldosterone-Stimulated SGK1 Activity Mediates Profibrotic Signaling in the Mesangium J. Am. Soc. Nephrol., February 1, 2008; 19(2): 298 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Taruno, N. Niisato, and Y. Marunaka Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells Am J Physiol Renal Physiol, January 1, 2008; 294(1): F177 - F186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Li, S. Koshy, and H. G. Folkesson Involvement of {alpha}ENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L1069 - L1078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O. Wielputz, I.-H. Lee, A. Dinudom, S. Boulkroun, N. Farman, D. I. Cook, C. Korbmacher, and R. Rauh (NDRG2) Stimulates Amiloride-sensitive Na+ Currents in Xenopus laevis Oocytes and Fisher Rat Thyroid Cells J. Biol. Chem., September 21, 2007; 282(38): 28264 - 28273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Husted, K. A. Volk, R. D. Sigmund, and J. B. Stokes Discordant effects of corticosteroids and expression of subunits on ENaC activity Am J Physiol Renal Physiol, September 1, 2007; 293(3): F813 - F820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Martel, D. Michael, G. Fejes-Toth, and A. Naray-Fejes-Toth Melanophilin, a novel aldosterone-induced gene in mouse cortical collecting duct cells Am J Physiol Renal Physiol, September 1, 2007; 293(3): F904 - F913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Pao, J. A. McCormick, H. Li, J. Siu, C. Govaerts, V. Bhalla, R. Soundararajan, and D. Pearce NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1741 - F1750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cordas, A. Naray-Fejes-Toth, and G. Fejes-Toth Subcellular location of serum- and glucocorticoid-induced kinase-1 in renal and mammary epithelial cells Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1971 - C1981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Fejes-Toth and A. Naray-Fejes-Toth Early Aldosterone-Regulated Genes in Cardiomyocytes: Clues to Cardiac Remodeling? Endocrinology, April 1, 2007; 148(4): 1502 - 1510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fakitsas, G. Adam, D. Daidie, M. X. van Bemmelen, F. Fouladkou, A. Patrignani, U. Wagner, R. Warth, S. M.R. Camargo, O. Staub, et al. Early Aldosterone-Induced Gene Product Regulates the Epithelial Sodium Channel by Deubiquitylation J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1084 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nielsen, T.-H. Kwon, J. Frokiaer, M. A. Knepper, and S. Nielsen Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade Am J Physiol Renal Physiol, January 1, 2007; 292(1): F382 - F394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. Huang, K. M. Boini, H. Osswald, B. Friedrich, F. Artunc, S. Ullrich, J. Rajamanickam, M. Palmada, P. Wulff, D. Kuhl, et al. Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1264 - F1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rexhepaj, F. Grahammer, H. Volkl, C. Remy, C. A. Wagner, D. Sandulache, F. Artunc, G. Henke, S. Nammi, G. Capasso, et al. Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice FASEB J, November 1, 2006; 20(13): 2214 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Sandu, F. Artunc, M. Palmada, R. Rexhepaj, F. Grahammer, A. Hussain, C. Yun, D. R. Alessi, and F. Lang Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G868 - G876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lang, C. Bohmer, M. Palmada, G. Seebohm, N. Strutz-Seebohm, and V. Vallon (Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms. Physiol Rev, October 1, 2006; 86(4): 1151 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bhalla, R. Soundararajan, A. C. Pao, H. Li, and D. Pearce Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ Am J Physiol Renal Physiol, October 1, 2006; 291(4): F714 - F721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Boini, A. M. Hennige, D. Y. Huang, B. Friedrich, M. Palmada, C. Boehmer, F. Grahammer, F. Artunc, S. Ullrich, D. Avram, et al. Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance. Diabetes, July 1, 2006; 55(7): 2059 - 2066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Ponda and T. H. Hostetter Aldosterone Antagonism in Chronic Kidney Disease Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 668 - 677. [Full Text] [PDF]
|
|
|
|
|
|
B. Malik, S. R. Price, W. E. Mitch, Q. Yue, and D. C. Eaton Regulation of epithelial sodium channels by the ubiquitin-proteasome proteolytic pathway Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1285 - F1294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Grahammer, G. Henke, C. Sandu, R. Rexhepaj, A. Hussain, B. Friedrich, T. Risler, M. Metzger, L. Just, T. Skutella, et al. Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1 Am J Physiol Gastrointest Liver Physiol, June 1, 2006; 290(6): G1114 - G1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lister, D. J. Autelitano, A. Jenkins, R. D. Hannan, and K. E. Sheppard Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: A possible role for SGK1 Cardiovasc Res, June 1, 2006; 70(3): 555 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pochynyuk, Q. Tong, A. Staruschenko, H.-P. Ma, and J. D. Stockand Regulation of the epithelial Na+ channel (ENaC) by phosphatidylinositides Am J Physiol Renal Physiol, May 1, 2006; 290(5): F949 - F957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Loffing-Cueni, S. Y. Flores, D. Sauter, D. Daidie, N. Siegrist, P. Meneton, O. Staub, and J. Loffing Dietary Sodium Intake Regulates the Ubiquitin-Protein Ligase Nedd4-2 in the Renal Collecting System J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1264 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Staub and D. Rotin Role of Ubiquitylation in Cellular Membrane Transport Physiol Rev, April 1, 2006; 86(2): 669 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Grahammer, F. Artunc, D. Sandulache, R. Rexhepaj, B. Friedrich, T. Risler, J. A. McCormick, K. Dawson, J. Wang, D. Pearce, et al. Renal function of gene-targeted mice lacking both SGK1 and SGK3 Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R945 - R950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. Huang, K. M. Boini, B. Friedrich, M. Metzger, L. Just, H. Osswald, P. Wulff, D. Kuhl, V. Vallon, and F. Lang Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1 Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R935 - R944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhang, X. Xia, D. I. Jalal, T. Kuncewicz, W. Xu, G. D. Lesage, and B. C. Kone Aldosterone-sensitive repression of ENaC{alpha} transcription by a histone H3 lysine-79 methyltransferase Am J Physiol Cell Physiol, March 1, 2006; 290(3): C936 - C946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Alvarez de la Rosa, I. Gimenez, B. Forbush, and C. M. Canessa SGK1 activates Na+-K+-ATPase in amphibian renal epithelial cells Am J Physiol Cell Physiol, February 1, 2006; 290(2): C492 - C498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bhalla, D. Daidie, H. Li, A. C. Pao, L. P. LaGrange, J. Wang, A. Vandewalle, J. D. Stockand, O. Staub, and D. Pearce Serum- and Glucocorticoid-Regulated Kinase 1 Regulates Ubiquitin Ligase Neural Precursor Cell-Expressed, Developmentally Down-Regulated Protein 4-2 by Inducing Interaction with 14-3-3 Mol. Endocrinol., December 1, 2005; 19(12): 3073 - 3084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Staub and F. Verrey Impact of Nedd4 Proteins and Serum and Glucocorticoid-Induced Kinases on Epithelial Na+ Transport in the Distal Nephron J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3167 - 3174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Loffing and L. Schild Functional Domains of the Epithelial Sodium Channel J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3175 - 3181. [Full Text] [PDF]
|
|
|
|
|
|
D. Wang, H. Sun, F. Lang, and C. C. Yun Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1 Am J Physiol Cell Physiol, October 1, 2005; 289(4): C802 - C810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Helms, L. Yu, B. Malik, D. J. Kleinhenz, C. M. Hart, and D. C. Eaton Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia Am J Physiol Cell Physiol, September 1, 2005; 289(3): C717 - C726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Flores, D. Loffing-Cueni, E. Kamynina, D. Daidie, C. Gerbex, S. Chabanel, J. Dudler, J. Loffing, and O. Staub Aldosterone-Induced Serum and Glucocorticoid-Induced Kinase 1 Expression Is Accompanied by Nedd4-2 Phosphorylation and Increased Na+ Transport in Cortical Collecting Duct Cells J. Am. Soc. Nephrol., August 1, 2005; 16(8): 2279 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Itani, J. B. Stokes, and C. P. Thomas Nedd4-2 isoforms differentially associate with ENaC and regulate its activity Am J Physiol Renal Physiol, August 1, 2005; 289(2): F334 - F346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. McCormick, V. Bhalla, A. C. Pao, and D. Pearce SGK1: A Rapid Aldosterone-Induced Regulator of Renal Sodium Reabsorption Physiology, April 1, 2005; 20(2): 134 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ichimura, H. Yamamura, K. Sasamoto, Y. Tominaga, M. Taoka, K. Kakiuchi, T. Shinkawa, N. Takahashi, S. Shimada, and T. Isobe 14-3-3 Proteins Modulate the Expression of Epithelial Na+ Channels by Phosphorylation-dependent Interaction with Nedd4-2 Ubiquitin Ligase J. Biol. Chem., April 1, 2005; 280(13): 13187 - 13194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boyd and A. Naray-Fejes-Toth Gene regulation of ENaC subunits by serum- and glucocorticoid-inducible kinase-1 Am J Physiol Renal Physiol, March 1, 2005; 288(3): F505 - F512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhou and P. M. Snyder Nedd4-2 Phosphorylation Induces Serum and Glucocorticoid-regulated Kinase (SGK) Ubiquitination and Degradation J. Biol. Chem., February 11, 2005; 280(6): 4518 - 4523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen, B. Yang, J. A. McNulty, L. G. Clifton, J. G. Binz, A. M. Grimes, J. C. Strum, W. W. Harrington, Z. Chen, T. W. Balon, et al. GI262570, a Peroxisome Proliferator-Activated Receptor {gamma} Agonist, Changes Electrolytes and Water Reabsorption from the Distal Nephron in Rats J. Pharmacol. Exp. Ther., February 1, 2005; 312(2): 718 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Stockand Preserving salt: in vivo studies with Sgk1-deficient mice define a modern role for this ancient protein Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R1 - R3. [Full Text] [PDF]
|
|
|
|
|
|
V. Vallon, P. Wulff, D. Y. Huang, J. Loffing, H. Volkl, D. Kuhl, and F. Lang Role of Sgk1 in salt and potassium homeostasis Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R4 - R10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Menniti, R. Iuliano, R. Amato, R. Boito, M. Corea, I. Le Pera, E. Gulletta, G. Fuiano, and N. Perrotti Serum and glucocorticoid-regulated kinase Sgk1 inhibits insulin-dependent activation of phosphomannomutase 2 in transfected COS-7 cells Am J Physiol Cell Physiol, January 1, 2005; 288(1): C148 - C155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Naray-Fejes-Toth, P. M. Snyder, and G. Fejes-Toth The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport PNAS, December 14, 2004; 101(50): 17434 - 17439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lang Surfing the lipid bilayer: how basolateral insulin receptors regulate Na+ channels in the apical cell membrane. Focus on "Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na+ channels" Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1539 - C1540. [Full Text] [PDF]
|
|
|
|
|
|
P. M. Snyder, D. R. Olson, R. Kabra, R. Zhou, and J. C. Steines cAMP and Serum and Glucocorticoid-inducible Kinase (SGK) Regulate the Epithelial Na+ Channel through Convergent Phosphorylation of Nedd4-2 J. Biol. Chem., October 29, 2004; 279(44): 45753 - 45758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamamura, S. Ugawa, T. Ueda, M. Nagao, and S. Shimada Capsazepine Is a Novel Activator of the {delta} Subunit of the Human Epithelial Na+ Channel J. Biol. Chem., October 22, 2004; 279(43): 44483 - 44489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Meneton, J. Loffing, and D. G. Warnock Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule Am J Physiol Renal Physiol, October 1, 2004; 287(4): F593 - F601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Thomas, J. R. Campbell, P. J. Wright, and R. F. Husted cAMP-stimulated Na+ transport in H441 distal lung epithelial cells: role of PKA, phosphatidylinositol 3-kinase, and sgk1 Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L843 - L851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. de la Rosa, T. G. Paunescu, W. J. Els, S. I. Helman, and C. M. Canessa Mechanisms of Regulation of Epithelial Sodium Channel by SGK1 in A6 Cells J. Gen. Physiol., September 27, 2004; 124(4): 395 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Diakov and C. Korbmacher A Novel Pathway of Epithelial Sodium Channel Activation Involves a Serum- and Glucocorticoid-inducible Kinase Consensus Motif in the C Terminus of the Channel's {alpha}-Subunit J. Biol. Chem., September 10, 2004; 279(37): 38134 - 38142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fouladkou, R. Alikhani-Koopaei, B. Vogt, S. Y. Flores, L. Malbert-Colas, M.-C. Lecomte, J. Loffing, F. J. Frey, B. M. Frey, and O. Staub A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes Am J Physiol Renal Physiol, September 1, 2004; 287(3): F550 - F561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Freel and J. M.C. Connell Mechanisms of Hypertension: The Expanding Role of Aldosterone J. Am. Soc. Nephrol., August 1, 2004; 15(8): 1993 - 2001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Palmada, M. Dieter, A. Speil, C. Bohmer, A. F. Mack, H. J. Wagner, K. Klingel, R. Kandolf, H. Murer, J. Biber, et al. Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1 Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G143 - G150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A.J. Devonald and F. E. Karet Renal Epithelial Traffic Jams and One-Way Streets J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1370 - 1381. [Full Text] [PDF]
|
|
|
|
|
|
R. Sepehrdad, P. N. Chander, G. Singh, and C. T. Stier Jr Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1185 - F1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Tong, R. E. Booth, R. T. Worrell, and J. D. Stockand Regulation of Na+ transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1232 - F1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schniepp, K. Kohler, T. Ladewig, E. Guenther, G. Henke, M. Palmada, C. Boehmer, J. D. Rothstein, S. Broer, and F. Lang Retinal Colocalization and In Vitro Interaction of the Glutamate Receptor EAAT3 and the Serum- and Glucocorticoid-Inducible Kinase SGK1 Invest. Ophthalmol. Vis. Sci., May 1, 2004; 45(5): 1442 - 1449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gonzalez-Nunez, M. Morales-Ruiz, A. Leivas, S. C. Hebert, and E. Poch In vitro characterization of aldosterone and cAMP effects in mouse distal convoluted tubule cells Am J Physiol Renal Physiol, May 1, 2004; 286(5): F936 - F944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. Huang, P. Wulff, H. Volkl, J. Loffing, K. Richter, D. Kuhl, F. Lang, and V. Vallon Impaired Regulation of Renal K+ Elimination in the sgk1-Knockout Mouse J. Am. Soc. Nephrol., April 1, 2004; 15(4): 885 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Snyder, J. C. Steines, and D. R. Olson Relative Contribution of Nedd4 and Nedd4-2 to ENaC Regulation in Epithelia Determined by RNA Interference J. Biol. Chem., February 6, 2004; 279(6): 5042 - 5046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Gumz, M. P. Popp, C. S. Wingo, and B. D. Cain Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line Am J Physiol Renal Physiol, October 1, 2003; 285(4): F664 - F673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. de la Rosa, T. Coric, N. Todorovic, D. Shao, T. Wang, and C. M Canessa Distribution and regulation of expression of serum- and glucocorticoid-induced kinase-1 in the rat kidney J. Physiol., September 1, 2003; 551(2): 455 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Auberson, N. Hoffmann-Pochon, A. Vandewalle, S. Kellenberger, and L. Schild Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin Am J Physiol Renal Physiol, September 1, 2003; 285(3): F459 - F471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yoo, B. Y. Kim, C. Campo, L. Nance, A. King, D. Maouyo, and P. A. Welling Cell Surface Expression of the ROMK (Kir 1.1) Channel Is Regulated by the Aldosterone-induced Kinase, SGK-1, and Protein Kinase A J. Biol. Chem., June 13, 2003; 278(25): 23066 - 23075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Blazer-Yost, M. A. Esterman, and C. J. Vlahos Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity Am J Physiol Cell Physiol, June 1, 2003; 284(6): C1645 - C1653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. G. Muller, R. G. Parnova, G. Centeno, B. C. Rossier, D. Firsov, and J.-D. Horisberger Mineralocorticoid Effects in the Kidney: Correlation between {alpha}ENaC, GILZ, and Sgk-1 mRNA Expression and Urinary Excretion of Na+ and K+ J. Am. Soc. Nephrol., May 1, 2003; 14(5): 1107 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Loffing and B. Kaissling Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human Am J Physiol Renal Physiol, April 1, 2003; 284(4): F628 - F643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Itani, K. L. Cornish, K. Z. Liu, and C. P. Thomas Cycloheximide increases glucocorticoid-stimulated alpha -ENaC mRNA in collecting duct cells by p38 MAPK-dependent pathway Am J Physiol Renal Physiol, April 1, 2003; 284(4): F778 - F787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Farjah, B. P. Roxas, D. L. Geenen, and R. S. Danziger Dietary Salt Regulates Renal SGK1 Abundance: Relevance to Salt Sensitivity in the Dahl Rat Hypertension, April 1, 2003; 41(4): 874 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boehmer, V. Wilhelm, M. Palmada, S. Wallisch, G. Henke, H. Brinkmeier, P. Cohen, B. Pieske, and F. Lang Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A Cardiovasc Res, March 15, 2003; 57(4): 1079 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Helms, G. Fejes-Toth, and A. Naray-Fejes-Toth Hormone-regulated transepithelial Na+ transport in mammalian CCD cells requires SGK1 expression Am J Physiol Renal Physiol, March 1, 2003; 284(3): F480 - F487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Maiyar, M. L.L. Leong, and G. L. Firestone Importin-alpha Mediates the Regulated Nuclear Targeting of Serum- and Glucocorticoid-inducible Protein Kinase (Sgk) by Recognition of a Nuclear Localization Signal in the Kinase Central Domain Mol. Biol. Cell, March 1, 2003; 14(3): 1221 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. L. Leong, A. C. Maiyar, B. Kim, B. A. O'Keeffe, and G. L. Firestone Expression of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, Is a Cell Survival Response to Multiple Types of Environmental Stress Stimuli in Mammary Epithelial Cells J. Biol. Chem., February 14, 2003; 278(8): 5871 - 5882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Alvarez de la Rosa and C. M. Canessa Role of SGK in hormonal regulation of epithelial sodium channel in A6 cells Am J Physiol Cell Physiol, February 1, 2003; 284(2): C404 - C414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. Wilson, K. T. Kahle, E. Sabath, M. D. Lalioti, A. K. Rapson, R. S. Hoover, S. C. Hebert, G. Gamba, and R. P. Lifton Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4 PNAS, January 21, 2003; 100(2): 680 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Yun, M. Palmada, H. M. Embark, O. Fedorenko, Y. Feng, G. Henke, I. Setiawan, C. Boehmer, E. J. Weinman, S. Sandrasagra, et al. The Serum and Glucocorticoid-Inducible Kinase SGK1 and the Na+/H+ Exchange Regulating Factor NHERF2 Synergize to Stimulate the Renal Outer Medullary K+ Channel ROMK1 J. Am. Soc. Nephrol., December 1, 2002; 13(12): 2823 - 2830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. Itani, K. Z. Liu, K. L. Cornish, J. R. Campbell, and C. P. Thomas Glucocorticoids stimulate human sgk1 gene expression by activation of a GRE in its 5'-flanking region Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E971 - E979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nielsen, T.-H. Kwon, S. Masilamani, K. Beutler, H. Hager, S. Nielsen, and M. A. Knepper Sodium transporter abundance profiling in kidney: effect of spironolactone Am J Physiol Renal Physiol, November 1, 2002; 283(5): F923 - F933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Becchetti, B. Malik, G. Yue, P. Duchatelle, O. Al-Khalili, T. R. Kleyman, and D. C. Eaton Phosphatase inhibitors increase the open probability of ENaC in A6 cells Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1030 - F1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Bonny and B. C. Rossier Disturbances of Na/K Balance: Pseudohypoaldosteronism Revisited J. Am. Soc. Nephrol., September 1, 2002; 13(9): 2399 - 2414. [Full Text] [PDF]
|
|
|
|
|
|
E. Kamynina and O. Staub Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na+ transport Am J Physiol Renal Physiol, September 1, 2002; 283(3): F377 - F387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Busjahn, A. Aydin, R. Uhlmann, C. Krasko, S. Bahring, T. Szelestei, Y. Feng, S. Dahm, A. M. Sharma, F. C. Luft, et al. Serum- and Glucocorticoid-Regulated Kinase (SGK1) Gene and Blood Pressure Hypertension, September 1, 2002; 40(3): 256 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Boulkroun, M. Fay, M.-C. Zennaro, B. Escoubet, F. Jaisser, M. Blot-Chabaud, N. Farman, and N. Courtois-Coutry Characterization of Rat NDRG2 (N-Myc Downstream Regulated Gene 2), a Novel Early Mineralocorticoid-specific Induced Gene J. Biol. Chem., August 23, 2002; 277(35): 31506 - 31515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vuagniaux, V. Vallet, N. F. Jaeger, E. Hummler, and B. C. Rossier Synergistic Activation of ENaC by Three Membrane-bound Channel-activating Serine Proteases (mCAP1, mCAP2, and mCAP3) and Serum- and Glucocorticoid-regulated Kinase (Sgk1) in Xenopus Oocytes J. Gen. Physiol., July 30, 2002; 120(2): 191 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kellenberger and L. Schild Epithelial Sodium Channel/Degenerin Family of Ion Channels: A Variety of Functions for a Shared Structure Physiol Rev, July 1, 2002; 82(3): 735 - 767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Rozansky, J. Wang, N. Doan, T. Purdy, T. Faulk, A. Bhargava, K. Dawson, and D. Pearce Hypotonic induction of SGK1 and Na+ transport in A6 cells Am J Physiol Renal Physiol, July 1, 2002; 283(1): F105 - F113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Rossier Hormonal Regulation of the Epithelial Sodium Channel ENaC: N or Po? J. Gen. Physiol., June 24, 2002; 120(1): 67 - 70. [Full Text] [PDF]
|
|
|
|
|
|
C. E. Deppe, P. J. Heering, S. Viengchareun, B. Grabensee, N. Farman, and M. Lombes Cyclosporine A and FK506 Inhibit Transcriptional Activity of the Human Mineralocorticoid Receptor: A Cell-Based Model to Investigate Partial Aldosterone Resistance in Kidney Transplantation Endocrinology, May 1, 2002; 143(5): 1932 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hou, H. J. L. Speirs, J. R. Seckl, and R. W. Brown Sgk1 Gene Expression in Kidney and Its Regulation by Aldosterone: Spatio-Temporal Heterogeneity and Quantitative Analysis J. Am. Soc. Nephrol., May 1, 2002; 13(5): 1190 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shi, C. Asher, A. Chigaev, Y. Yung, E. Reuveny, R. Seger, and H. Garty Interactions of beta and gamma ENaC with Nedd4 Can Be Facilitated by an ERK-mediated Phosphorylation J. Biol. Chem., April 12, 2002; 277(16): 13539 - 13547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Snyder The Epithelial Na+ Channel: Cell Surface Insertion and Retrieval in Na+ Homeostasis and Hypertension Endocr. Rev., April 1, 2002; 23(2): 258 - 275. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |