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J Biol Chem, Vol. 274, Issue 24, 17159-17163, June 11, 1999
From the We have isolated a novel liver-specific organic
anion transporter, LST-1, that is expressed exclusively in the human,
rat, and mouse liver. LST-1 is a new gene family located between the organic anion transporter family and prostaglandin transporter. LST-1
transports taurocholate (Km = 13.6 µM) in a sodium-independent manner. LST-1 also shows
broad substrate specificity. It transports conjugated steroids
(dehydroepiandrosterone sulfate, estradiol-17 LST-1 is probably the most important transporter in human liver
for clearance of bile acids and organic anions because hepatic levels
of another organic anion transporter, OATP, is very low. This is also
the first report of the human molecule that transports thyroid hormones.
Identification of a Novel Gene Family Encoding Human
Liver-specific Organic Anion Transporter LST-1
,
,,,,,,, and
Department of Neurophysiology, 1st
Department of Surgery, Department of
Pediatrics,
-glucuronide, and
estrone-3-sulfate), eicosanoids (prostaglandin E2,
thromboxane B2, leukotriene C4, leukotriene
E4), and thyroid hormones (thyroxine, Km = 3.0 µM and triiodothyronine,
Km = 2.7 µM), reflecting hepatic multispecificity.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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B. Gao, B. Hagenbuch, G. A. Kullak-Ublick, D. Benke, A. Aguzzi, and P. J. Meier Organic Anion-Transporting Polypeptides Mediate Transport of Opioid Peptides across Blood-Brain Barrier J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 73 - 79. [Abstract] [Full Text]
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J. Konig, Y. Cui, A. T. Nies, and D. Keppler A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane Am J Physiol Gastrointest Liver Physiol, January 1, 2000; 278(1): G156 - G164. [Abstract] [Full Text] [PDF]
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B. Hsiang, Y. Zhu, Z. Wang, Y. Wu, V. Sasseville, W.-P. Yang, and T. G. Kirchgessner A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2). IDENTIFICATION OF A LIVER-SPECIFIC HUMAN ORGANIC ANION TRANSPORTING POLYPEPTIDE AND IDENTIFICATION OF RAT AND HUMAN HYDROXYMETHYLGLUTARYL-CoA REDUCTASE INHIBITOR TRANSPORTERS J. Biol. Chem., December 24, 1999; 274(52): 37161 - 37168. [Abstract] [Full Text] [PDF]
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J. Konig, Y. Cui, A. T. Nies, and D. Keppler Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide J. Biol. Chem., July 21, 2000; 275(30): 23161 - 23168. [Abstract] [Full Text] [PDF]
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Y. Cui, J. Konig, I. Leier, U. Buchholz, and D. Keppler Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6 J. Biol. Chem., March 23, 2001; 276(13): 9626 - 9630. [Abstract] [Full Text] [PDF]
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E. Battaglia and J. Gollan A Unique Multifunctional Transporter Translocates Estradiol-17beta -Glucuronide in Rat Liver Microsomal Vesicles J. Biol. Chem., June 22, 2001; 276(26): 23492 - 23498. [Abstract] [Full Text] [PDF]
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R. G. Tirona, B. F. Leake, G. Merino, and R. B. Kim Polymorphisms in OATP-C. IDENTIFICATION OF MULTIPLE ALLELIC VARIANTS ASSOCIATED WITH ALTERED TRANSPORT ACTIVITY AMONG EUROPEAN- AND AFRICAN-AMERICANS J. Biol. Chem., September 14, 2001; 276(38): 35669 - 35675. [Abstract] [Full Text] [PDF]
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D. Jung, B. Hagenbuch, L. Gresh, M. Pontoglio, P. J. Meier, and G. A. Kullak-Ublick Characterization of the Human OATP-C (SLC21A6) Gene Promoter and Regulation of Liver-specific OATP Genes by Hepatocyte Nuclear Factor 1alpha J. Biol. Chem., September 28, 2001; 276(40): 37206 - 37214. [Abstract] [Full Text] [PDF]
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