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J Biol Chem, Vol. 274, Issue 27, 18847-18850, July 2, 1999
From the Department of Molecular Physiology and Biophysics,
Vanderbilt University, School of Medicine,
Nashville, Tennessee 37232-0615
We demonstrate, utilizing a temperature
conditional mutant allele of the gene encoding TAF25p, that this
non-histone-like TBP-associated factor, which is shared between the
TFIID and SAGA complexes, is required for bulk mRNA gene
transcription by RNA polymerase II in vivo. Immunoblotting
experiments indicate that at the restrictive temperature, inactivation
of TAF25p function results in a reduction of the levels of numerous
TFIID and SAGA subunits, indicating its loss of function, like the
histone-like TAFs, causes degradation of the constituents of these two
multisubunit complexes. These data suggest that TAF25p plays a key
structural role in maintaining TFIID and SAGA complex integrity. This
is the first demonstration that a non-histone-like TAF is required for
continuous, high level RNA polymerase II-mediated mRNA gene transcription in living yeast cells.
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S. L. Sanders and P. A. Weil Identification of Two Novel TAF Subunits of the Yeast Saccharomyces cerevisiae TFIID Complex J. Biol. Chem., April 28, 2000; 275(18): 13895 - 13900. [Abstract] [Full Text] [PDF]
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S. Georgieva, D. B. Kirschner, T. Jagla, E. Nabirochkina, S. Hanke, H. Schenkel, C. de Lorenzo, P. Sinha, K. Jagla, B. Mechler, et al. Two Novel Drosophila TAFIIs Have Homology with Human TAFII30 and Are Differentially Regulated during Development Mol. Cell. Biol., March 1, 2000; 20(5): 1639 - 1648. [Abstract] [Full Text]
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Y.-G. Gangloff, S. Werten, C. Romier, L. Carré, O. Poch, D. Moras, and I. Davidson The Human TFIID Components TAFII135 and TAFII20 and the Yeast SAGA Components ADA1 and TAFII68 Heterodimerize to Form Histone-Like Pairs Mol. Cell. Biol., January 1, 2000; 20(1): 340 - 351. [Abstract] [Full Text]
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 P. B. Komarnitsky, B. Michel, and S. Buratowski TFIID-specific yeast TAF40 is essential for the majority of RNA polymerase II-mediated transcription in vivo Genes & Dev., October 1, 1999; 13(19): 2484 - 2489. [Abstract] [Full Text]
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J. C. Reese, Z. Zhang, and H. Kurpad Identification of a Yeast Transcription Factor IID Subunit, TSG2/TAF48 J. Biol. Chem., June 2, 2000; 275(23): 17391 - 17398. [Abstract] [Full Text] [PDF]
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M. Lemaire and M. A. Collart The TATA-binding Protein-associated Factor yTafII19p Functionally Interacts with Components of the Global Transcriptional Regulator Ccr4-Not Complex and Physically Interacts with the Not5 Subunit J. Biol. Chem., August 25, 2000; 275(35): 26925 - 26934. [Abstract] [Full Text] [PDF]
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J. Wang and G. Dreyfuss A Cell System with Targeted Disruption of the SMN Gene. FUNCTIONAL CONSERVATION OF THE SMN PROTEIN AND DEPENDENCE OF Gemin2 ON SMN J. Biol. Chem., March 23, 2001; 276(13): 9599 - 9605. [Abstract] [Full Text] [PDF]
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H. Mitsuzawa, H. Seino, F. Yamao, and A. Ishihama Two WD Repeat-containing TATA-binding Protein-associated Factors in Fission Yeast That Suppress Defects in the Anaphase-promoting Complex J. Biol. Chem., May 11, 2001; 276(20): 17117 - 17124. [Abstract] [Full Text] [PDF]
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A. Rashevsky-Finkel, A. Silkov, and R. Dikstein A Composite Nuclear Export Signal in the TBP-associated Factor TAFII105 J. Biol. Chem., November 21, 2001; 276(48): 44963 - 44969. [Abstract] [Full Text] [PDF]
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U. Banik, J. M. Beechem, E. Klebanow, S. Schroeder, and P. A. Weil Fluorescence-based Analyses of the Effects of Full-length Recombinant TAF130p on the Interaction of TATA Box-binding Protein with TATA Box DNA J. Biol. Chem., December 21, 2001; 276(52): 49100 - 49109. [Abstract] [Full Text] [PDF]
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