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J Biol Chem, Vol. 274, Issue 27, 19003-19010, July 2, 1999
PKC and the Tyrosine
Kinase p59fyn
From Telik, Inc., South San Francisco, California 94080
The protein kinase C (PKC) family has been
clearly implicated in T-cell activation as have several nonreceptor
protein-tyrosine kinases associated with the T-cell receptor, including
p59fyn. This report demonstrates that 
PKC and p59fyn specifically
interact in vitro, in the yeast two-hybrid system, and in
T-cells. Further indications of direct interaction are that p59fyn
potentiates PKC catalytic activity and that PKC is a substrate
for tyrosine phosphorylation by p59fyn. This interaction may account
for the localization of PKC following T-cell activation,
pharmacological disruption of which results in specific cell-signaling
defects. The demonstration of a physical interaction between a PKC and a protein-tyrosine kinase expands the class of PKC-anchoring proteins (receptors for activated C kinases (RACKs)) and demonstrates a direct
connection between these two major T-cell-signaling pathways.
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