JBC Anatrace, Inc.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tanaka, N.
Right arrow Articles by Sugamura, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tanaka, N.
Right arrow Articles by Sugamura, K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J Biol Chem, Vol. 274, Issue 27, 19129-19135, July 2, 1999

Possible Involvement of a Novel STAM-associated Molecule "AMSH" in Intracellular Signal Transduction Mediated by Cytokines

Nobuyuki TanakaDagger , Kenzo KanekoDagger , Hironobu AsaoDagger , Hirotake KasaiDagger , Yuichi Endo§, Teizo Fujita§, Toshikazu TakeshitaDagger , and Kazuo SugamuraDagger

From the Dagger  Department of Microbiology and Immunology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, the § Department of Biochemistry, Fukushima Medical College, 1 Hikarigaoka, Fukushima 960-12, and  Core Research for Evolutional Science and Technology, the Japan Science and Technology Corporation, Tokyo 101-0062, Japan

STAM containing an SH3 (Src homology 3) domain and an immunoreceptor tyrosine-based activation motif was previously revealed to be implicated in signaling pathways immediately downstream of Jak2 and Jak3 tyrosine kinases associated with cytokine receptors. We molecularly cloned a novel molecule interacting with the SH3 domain of STAM, which was named AMSH (associated molecule with the SH3 domain of STAM). AMSH contains a putative bipartite nuclear localization signal and a homologous region of a c-Jun activation domain-binding protein 1 (JAB1) subdomain in addition to a binding site for the SH3 domain of STAM. AMSH mutant deleted of the C-terminal half conferred dominant negative effects on signaling for DNA synthesis and c-myc induction mediated by interleukin 2 and granulocyte macrophage-colony-stimulating factor. These results suggest that AMSH plays a critical role in the cytokine-mediated intracellular signal transduction downstream of the Jak2/Jak3·STAM complex.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
A. Mukai, E. Mizuno, K. Kobayashi, M. Matsumoto, K. I. Nakayama, N. Kitamura, and M. Komada
Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis
J. Cell Sci., April 15, 2008; 121(8): 1325 - 1333.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. E. Row, H. Liu, S. Hayes, R. Welchman, P. Charalabous, K. Hofmann, M. J. Clague, C. M. Sanderson, and S. Urbe
The MIT Domain of UBPY Constitutes a CHMP Binding and Endosomal Localization Signal Required for Efficient Epidermal Growth Factor Receptor Degradation
J. Biol. Chem., October 19, 2007; 282(42): 30929 - 30937.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
T. Iwaki, M. Onishi, M. Ikeuchi, A. Kita, R. Sugiura, Y. Giga-Hama, Y. Fukui, and K. Takegawa
Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe
Microbiology, August 1, 2007; 153(8): 2753 - 2764.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. M. Ma, E. Boucrot, J. Villen, E. B. Affar, S. P. Gygi, H. G. Gottlinger, and T. Kirchhausen
Targeting of AMSH to Endosomes Is Required for Epidermal Growth Factor Receptor Degradation
J. Biol. Chem., March 30, 2007; 282(13): 9805 - 9812.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Ren, Y. Kee, J. M. Huibregtse, and R. C. Piper
Hse1, a Component of the Yeast Hrs-STAM Ubiquitin-sorting Complex, Associates with Ubiquitin Peptidases and a Ligase to Control Sorting Efficiency into Multivesicular Bodies
Mol. Biol. Cell, January 1, 2007; 18(1): 324 - 335.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Zamborlini, Y. Usami, S. R. Radoshitzky, E. Popova, G. Palu, and H. Gottlinger
Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding
PNAS, December 12, 2006; 103(50): 19140 - 19145.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Langelier, U. K. von Schwedler, R. D. Fisher, I. De Domenico, P. L. White, C. P. Hill, J. Kaplan, D. Ward, and W. I. Sundquist
Human ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release
J. Virol., October 1, 2006; 80(19): 9465 - 9480.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Agromayor and J. Martin-Serrano
Interaction of AMSH with ESCRT-III and Deubiquitination of Endosomal Cargo
J. Biol. Chem., August 11, 2006; 281(32): 23083 - 23091.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
M. Nakamura, N. Tanaka, N. Kitamura, and M. Komada
Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes
Genes Cells, June 1, 2006; 11(6): 593 - 606.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. E. Row, I. A. Prior, J. McCullough, M. J. Clague, and S. Urbe
The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation
J. Biol. Chem., May 5, 2006; 281(18): 12618 - 12624.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
E. Mizuno, T. Iura, A. Mukai, T. Yoshimori, N. Kitamura, and M. Komada
Regulation of Epidermal Growth Factor Receptor Down-Regulation by UBPY-mediated Deubiquitination at Endosomes
Mol. Biol. Cell, November 1, 2005; 16(11): 5163 - 5174.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
M. Komada and N. Kitamura
The Hrs/STAM Complex in the Downregulation of Receptor Tyrosine Kinases
J. Biochem., January 1, 2005; 137(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. McCullough, M. J. Clague, and S. Urbe
AMSH is an endosome-associated ubiquitin isopeptidase
J. Cell Biol., August 16, 2004; 166(4): 487 - 492.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Yamada, N. Ishii, H. Asao, K. Murata, C. Kanazawa, H. Sasaki, and K. Sugamura
Signal-Transducing Adaptor Molecules STAM1 and STAM2 Are Required for T-Cell Development and Survival
Mol. Cell. Biol., December 15, 2002; 22(24): 8648 - 8658.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
E. S. Seto, H. J. Bellen, and T. E. Lloyd
When cell biology meets development: endocytic regulation of signaling pathways
Genes & Dev., June 1, 2002; 16(11): 1314 - 1336.
[Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Ishii, Y. Owada, M. Yamada, S. Miura, K. Murata, H. Asao, H. Kondo, and K. Sugamura
Loss of Neurons in the Hippocampus and Cerebral Cortex of AMSH-Deficient Mice
Mol. Cell. Biol., December 15, 2001; 21(24): 8626 - 8637.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Kato, K. Miyazawa, and N. Kitamura
A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKP
J. Biol. Chem., November 22, 2000; 275(48): 37481 - 37487.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1999 by the American Society for Biochemistry and Molecular Biology.