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J Biol Chem, Vol. 274, Issue 28, 19846-19851, July 9, 1999
From the Ligand binding to the angiotensin II (Ang II)
AT1 receptor on vascular smooth muscle cells (VSMCs)
activates the Janus-activated kinase (JAK)/signal transducers and
activators of transcription (STAT) pathway. We have shown previously
that the JAK2 tyrosine kinase and the Src family p59 Fyn tyrosine
kinase are required for Ang II-induced STAT1 tyrosine phosphorylation
in VSMCs. The mitogen-activated protein kinase phosphatase, MKP-1, is
required for STAT1 tyrosine dephosphorylation. In the present study,
using specific enzyme inhibitors and antisense oligonucleotides, we show that Ang II-induced tyrosine phosphorylation and nuclear translocation of STAT3 in VSMCs is mediated by p60 c-Src, whereas tyrosine dephosphorylation is mediated by calcineurin. Calcineurin is
activated in response to Ang II stimulation of VSMCs and is translocated to the nucleus. In addition, we show that Ang II-induced serine phosphorylation of STAT3 in VSMCs is mediated by
mitogen-activated protein kinase and that dephosphorylation is mediated
by protein phosphatase 2A (PP2A). PP2A translocates to the nucleus in
response to Ang II stimulation of VSMCs and forms a complex with STAT3 in an Ang II-dependent manner.
Regulation of Angiotensin II-induced Phosphorylation of STAT3 in
Vascular Smooth Muscle Cells
,,,,§¶, and§
Vascular Biology Center,
§ Department of Pharmacology and Toxicology, and
¶ Department of Pediatrics, Medical College of Georgia,
Augusta, Georgia 30912
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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