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J Biol Chem, Vol. 274, Issue 29, 20071-20074, July 16, 1999

COMMUNICATION
Defective Secretion of Saliva in Transgenic Mice Lacking Aquaporin-5 Water Channels

Tonghui Ma, Yualin Song, Annemarie Gillespie, Elaine J. Carlson, Charles J. Epstein, and A. S. Verkman

From the Departments of Medicine, Physiology, and Pediatrics, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0521

Aquaporin-5 (AQP5) is a water-selective transporting protein expressed in epithelial cells of serous acini in salivary gland. We generated AQP5 null mice by targeted gene disruption. The genotype distribution from intercross of founder AQP5 heterozygous mice was 70:69:29 wild-type:heterozygote:knockout, indicating impaired prenatal survival of the null mice. The knockout mice had grossly normal appearance, but grew ~20% slower than litter-matched wild-type mice when placed on solid food after weaning. Pilocarpine-stimulated saliva production was reduced by more than 60% in AQP5 knockout mice. Compared with the saliva from wild-type mice, the saliva from knockout mice was hypertonic (420 mosM) and dramatically more viscous. Amylase and protein secretion, functions of salivary mucous cells, were not affected by AQP5 deletion. Water channels AQP1 and AQP4 have also been localized to salivary gland; however, pilocarpine stimulation studies showed no defect in the volume or composition of saliva in AQP1 and AQP4 knockout mice. These results implicate a key role for AQP5 in saliva fluid secretion and provide direct evidence that high epithelial cell membrane water permeability is required for active, near-isosmolar fluid transport.

Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.


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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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