| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 3, 1189-1192, January 15, 1999
,,
From the A number of transcriptional coactivators possess
intrinsic histone acetylase activity, providing a direct link between
hyperacetylated chromatin and transcriptional activation. We have
determined the core histone residues acetylated in vitro by
recombinant p300 and PCAF within mononucleosomes. p300 specifically
acetylates all sites of histones H2A and H2B known to be acetylated in
bulk chromatin in vivo but preferentially acetylates
lysines 14 and 18 of histone H3 and lysines 5 and 8 of histone H4. PCAF
primarily acetylates lysine 14 of H3 but also less efficiently
acetylates lysine 8 of H4. PCAF in its native form, which is present in
a stable multimeric protein complex lacking p300/CBP, primarily acetylates H3 to a monoacetylated form, suggesting that PCAF-associated polypeptides do not alter the substrate specificity. These distinct patterns of acetylation by the p300 and PCAF may contribute to their
differential roles in transcriptional regulation.
Laboratory of Molecular Growth Regulation,
National Institute of Child Health and Human Development, National
Institutes of Health, Bethesda, Maryland 20892, the ¶ Department
of Biology, University of Rochester, Rochester, New York 14627, and the ** Department of Microbiology and Immunology, Baylor
College of Medicine, Houston, Texas 77030
This article has been cited by other articles:
|
|
 |
|
  P. M. Evans, W. Zhang, X. Chen, J. Yang, K. K. Bhakat, and C. Liu Kruppel-like Factor 4 Is Acetylated by p300 and Regulates Gene Transcription via Modulation of Histone Acetylation J. Biol. Chem., November 23, 2007; 282(47): 33994 - 34002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Cherasse, A.-C. Maurin, C. Chaveroux, C. Jousse, V. Carraro, L. Parry, C. Deval, C. Chambon, P. Fafournoux, and A. Bruhat The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP Nucleic Acids Res., September 27, 2007; 35(17): 5954 - 5965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Attia, C. Rachez, A. De Pauw, P. Avner, and U. C. Rogner Nap1l2 Promotes Histone Acetylation Activity during Neuronal Differentiation Mol. Cell. Biol., September 1, 2007; 27(17): 6093 - 6102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-T. Ahn, B. Huang, L. McPherson, C. Clayberger, and A. M. Krensky Dynamic Interplay of Transcriptional Machinery and Chromatin Regulates "Late" Expression of the Chemokine RANTES in T Lymphocytes Mol. Cell. Biol., January 1, 2007; 27(1): 253 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Green, H. Yoon, and J. M. Boss Epigenetic Regulation during B Cell Differentiation Controls CIITA Promoter Accessibility J. Immunol., September 15, 2006; 177(6): 3865 - 3873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Hobbs, G. Wei, K. DeFeo, B. Paul, C. S. Hayes, and S. K. Gilmour Tip60 Protein Isoforms and Altered Function in Skin and Tumors that Overexpress Ornithine Decarboxylase Cancer Res., August 15, 2006; 66(16): 8116 - 8122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Majumder, J. A. Gomez, and J. M. Boss The Human Major Histocompatibility Complex Class II HLA-DRB1 and HLA-DQA1 Genes Are Separated by a CTCF-binding Enhancer-blocking Element J. Biol. Chem., July 7, 2006; 281(27): 18435 - 18443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueda, Y. V. Postnikov, and M. Bustin Distinct Domains in High Mobility Group N Variants Modulate Specific Chromatin Modifications J. Biol. Chem., April 14, 2006; 281(15): 10182 - 10187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Yoo, J.-J. Chung, S. S. Choe, K. H. Kim, and J. B. Kim Down-regulation of Histone Deacetylases Stimulates Adipocyte Differentiation J. Biol. Chem., March 10, 2006; 281(10): 6608 - 6615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Brackertz, Z. Gong, J. Leers, and R. Renkawitz p66{alpha} and p66{beta} of the Mi-2/NuRD complex mediate MBD2 and histone interaction Nucleic Acids Res., January 13, 2006; 34(2): 397 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Hassa, S. S. Haenni, C. Buerki, N. I. Meier, W. S. Lane, H. Owen, M. Gersbach, R. Imhof, and M. O. Hottiger Acetylation of Poly(ADP-ribose) Polymerase-1 by p300/CREB-binding Protein Regulates Coactivation of NF-{kappa}B-dependent Transcription J. Biol. Chem., December 9, 2005; 280(49): 40450 - 40464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kimura, K. Matsubara, and M. Horikoshi A Decade of Histone Acetylation: Marking Eukaryotic Chromosomes with Specific Codes J. Biochem., December 1, 2005; 138(6): 647 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B. Scribner, D. P. Odom, and M. M. McGrane Vitamin A Status in Mice Affects the Histone Code of the Phosphoenolpyruvate Carboxykinase Gene in Liver J. Nutr., December 1, 2005; 135(12): 2774 - 2779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. McCabe and J. W. Innis A genomic approach to the identification and characterization of HOXA13 functional binding elements Nucleic Acids Res., November 30, 2005; 33(21): 6782 - 6794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Gomez, P. Majumder, U. M. Nagarajan, and J. M. Boss X Box-Like Sequences in the MHC Class II Region Maintain Regulatory Function J. Immunol., July 15, 2005; 175(2): 1030 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Huddleson, N. Ahmad, S. Srinivasan, and J. B Lingrel Induction of KLF2 by Fluid Shear Stress Requires a Novel Promoter Element Activated by a Phosphatidylinositol 3-Kinase-dependent Chromatin-remodeling Pathway J. Biol. Chem., June 17, 2005; 280(24): 23371 - 23379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Baumeister, S. Luo, W. C. Skarnes, G. Sui, E. Seto, Y. Shi, and A. S. Lee Endoplasmic Reticulum Stress Induction of the Grp78/BiP Promoter: Activating Mechanisms Mediated by YY1 and Its Interactive Chromatin Modifiers Mol. Cell. Biol., June 1, 2005; 25(11): 4529 - 4540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Fu, R. A. McKnight, X. Yu, L. Wang, C. W. Callaway, and R. H. Lane Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver Physiol Genomics, December 15, 2004; 20(1): 108 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. B. Choi, J. K. Ko, and J. Shin The Transcriptional Corepressor, PELP1, Recruits HDAC2 and Masks Histones Using Two Separate Domains J. Biol. Chem., December 3, 2004; 279(49): 50930 - 50941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Daitoku, M. Hatta, H. Matsuzaki, S. Aratani, T. Ohshima, M. Miyagishi, T. Nakajima, and A. Fukamizu Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity PNAS, July 6, 2004; 101(27): 10042 - 10047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, K. Griffin, N. Mondal, and J. D. Parvin Phosphorylation of Histone H2A Inhibits Transcription on Chromatin Templates J. Biol. Chem., May 21, 2004; 279(21): 21866 - 21872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Peterson and J. Cote Cellular machineries for chromosomal DNA repair Genes & Dev., March 15, 2004; 18(6): 602 - 616. [Full Text] [PDF]
|
|
|
|
|
|
K. B. Scribner and M. M. McGrane RNA Polymerase II Association with the Phosphoenolpyruvate Carboxykinase (PEPCK) Promoter Is Reduced in Vitamin A-Deficient Mice J. Nutr., December 1, 2003; 133(12): 4112 - 4117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hong and D. Chakravarti The Human Proliferating Cell Nuclear Antigen Regulates Transcriptional Coactivator p300 Activity and Promotes Transcriptional Repression J. Biol. Chem., November 7, 2003; 278(45): 44505 - 44513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. McManus and M. J. Hendzel Quantitative Analysis of CBP- and P300-Induced Histone Acetylations In Vivo Using Native Chromatin Mol. Cell. Biol., November 1, 2003; 23(21): 7611 - 7627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Masumi, Y. Yamakawa, H. Fukazawa, K. Ozato, and K. Komuro Interferon Regulatory Factor-2 Regulates Cell Growth through Its Acetylation J. Biol. Chem., July 3, 2003; 278(28): 25401 - 25407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Mohan II, E. Scheer, O. Wendling, D. Metzger, and L. Tora TAF10 (TAFII30) Is Necessary for TFIID Stability and Early Embryogenesis in Mice Mol. Cell. Biol., June 15, 2003; 23(12): 4307 - 4318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, J. Wong, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley Progesterone and Glucocorticoid Receptors Recruit Distinct Coactivator Complexes and Promote Distinct Patterns of Local Chromatin Modification Mol. Cell. Biol., June 1, 2003; 23(11): 3763 - 3773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lachner, R. J. O'Sullivan, and T. Jenuwein An epigenetic road map for histone lysine methylation J. Cell Sci., June 1, 2003; 116(11): 2117 - 2124. [Full Text] [PDF]
|
|
|
|
|
|
S. A. Georges, H. A. Giebler, P. A. Cole, K. Luger, P. J. Laybourn, and J. K. Nyborg Tax Recruitment of CBP/p300, via the KIX Domain, Reveals a Potent Requirement for Acetyltransferase Activity That Is Chromatin Dependent and Histone Tail Independent Mol. Cell. Biol., May 15, 2003; 23(10): 3392 - 3404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Boekhoudt, Z. Guo, G. W. Beresford, and J. M. Boss Communication Between NF-{kappa}B and Sp1 Controls Histone Acetylation Within the Proximal Promoter of the Monocyte Chemoattractant Protein 1 Gene J. Immunol., April 15, 2003; 170(8): 4139 - 4147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamagoe, T. Kanno, Y. Kanno, S. Sasaki, R. M. Siegel, M. J. Lenardo, G. Humphrey, Y. Wang, Y. Nakatani, B. H. Howard, et al. Interaction of Histone Acetylases and Deacetylases In Vivo Mol. Cell. Biol., February 1, 2003; 23(3): 1025 - 1033. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. J. Fabian, B. F. Kimler, D. A. Brady, M. S. Mayo, C. H. J. Chang, J. A. Ferraro, C. M. Zalles, A. L. Stanton, S. Masood, W. E. Grizzle, et al. A Phase II Breast Cancer Chemoprevention Trial of Oral {alpha}-Difluoromethylornithine: Breast Tissue, Imaging, and Serum and Urine Biomarkers Clin. Cancer Res., October 1, 2002; 8(10): 3105 - 3117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lu, C. A. Pise-Masison, T. M. Fletcher, R. L. Schiltz, A. K. Nagaich, M. Radonovich, G. Hager, P. A. Cole, and J. N. Brady Acetylation of Nucleosomal Histones by p300 Facilitates Transcription from Tax-Responsive Human T-Cell Leukemia Virus Type 1 Chromatin Template Mol. Cell. Biol., July 1, 2002; 22(13): 4450 - 4462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Hartman, X. Hu, K. X. Tyler, C. K. Dalal, and M. A. Lazar Mechanisms Regulating Adipocyte Expression of Resistin J. Biol. Chem., May 24, 2002; 277(22): 19754 - 19761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Livengood, K. E. S. Scoggin, K. Van Orden, S. J. McBryant, R. S. Edayathumangalam, P. J. Laybourn, and J. K. Nyborg p53 Transcriptional Activity Is Mediated through the SRC1-interacting Domain of CBP/p300 J. Biol. Chem., March 8, 2002; 277(11): 9054 - 9061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Hobbs, B. A. Paul, and S. K. Gilmour Deregulation of Polyamine Biosynthesis Alters Intrinsic Histone Acetyltransferase and Deacetylase Activities in Murine Skin and Tumors Cancer Res., January 1, 2002; 62(1): 67 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hamiche, J.-G. Kang, C. Dennis, H. Xiao, and C. Wu Histone tails modulate nucleosome mobility and regulate ATP-dependent nucleosome sliding by NURF PNAS, November 20, 2001; (2001) 251421398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Manning, T. Ikehara, T. Ito, J. T. Kadonaga, and W. L. Kraus p300 Forms a Stable, Template-Committed Complex with Chromatin: Role for the Bromodomain Mol. Cell. Biol., June 15, 2001; 21(12): 3876 - 3887. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. T. Reutens, M. Fu, C. Wang, C. Albanese, M. J. McPhaul, Z. Sun, S. P. Balk, O. A. Jänne, J. J. Palvimo, and R. G. Pestell Cyclin D1 Binds the Androgen Receptor and Regulates Hormone-Dependent Signaling in a p300/CBP-Associated Factor (P/CAF)-Dependent Manner Mol. Endocrinol., May 1, 2001; 15(5): 797 - 811. [Abstract] [Full Text]
|
|
|
|
|
|
G. F. Sewack, T. W. Ellis, and U. Hansen Binding of TATA Binding Protein to a Naturally Positioned Nucleosome Is Facilitated by Histone Acetylation Mol. Cell. Biol., February 15, 2001; 21(4): 1404 - 1415. [Abstract] [Full Text]
|
|
|
|
|
|
F. D. Urnov and A. P. Wolffe A Necessary Good: Nuclear Hormone Receptors and Their Chromatin Templates Mol. Endocrinol., January 1, 2001; 15(1): 1 - 16. [Full Text]
|
|
|
|
|
|
K. Ito, P. J. Barnes, and I. M. Adcock Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1beta -Induced Histone H4 Acetylation on Lysines 8 and 12 Mol. Cell. Biol., September 15, 2000; 20(18): 6891 - 6903. [Abstract] [Full Text]
|
|
|
|
|
|
H. S. Kim, H. Yoon, I. Minn, C. B. Park, W. T. Lee, M. Zasloff, and S. C. Kim Pepsin-Mediated Processing of the Cytoplasmic Histone H2A to Strong Antimicrobial Peptide Buforin I J. Immunol., September 15, 2000; 165(6): 3268 - 3274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Bryant, P. Mixon, M. Davidson, A. J. Bannister, T. Kouzarides, and J. H. Sinclair The Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein Interacts Physically and Functionally with Histone Acetyltransferase P/CAF J. Virol., August 15, 2000; 74(16): 7230 - 7237. [Abstract] [Full Text]
|
|
|
|
|
|
T. Ito, T. Ikehara, T. Nakagawa, W. L. Kraus, and M. Muramatsu p300-Mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone Genes & Dev., August 1, 2000; 14(15): 1899 - 1907. [Abstract] [Full Text]
|
|
|
|
|
|
S. Kaul, J. A. Blackford Jr., J. Chen, V. V. Ogryzko, and S. S. Simons Jr. Properties of the Glucocorticoid Modulatory Element Binding Proteins GMEB-1 and -2: Potential New Modifiers of Glucocorticoid Receptor Transactivation and Members of the Family of KDWK Proteins Mol. Endocrinol., July 1, 2000; 14(7): 1010 - 1027. [Abstract] [Full Text]
|
|
|
|
|
|
S. Li, B. Aufiero, R. L. Schiltz, and M. J. Walsh Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP PNAS, June 13, 2000; (2000) 130028697. [Abstract] [Full Text]
|
|
|
|
|
|
M. K. Bennett and T. F. Osborne Nutrient regulation of gene expression by the sterol regulatory element binding proteins: Increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo PNAS, June 6, 2000; 97(12): 6340 - 6344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Sterner and S. L. Berger Acetylation of Histones and Transcription-Related Factors Microbiol. Mol. Biol. Rev., June 1, 2000; 64(2): 435 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Elefant, N. E. Cooke, and S. A. Liebhaber Targeted Recruitment of Histone Acetyltransferase Activity to a Locus Control Region J. Biol. Chem., April 28, 2000; 275(18): 13827 - 13834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Herrera, R. L. Schiltz, and M. Bustin The Accessibility of Histone H3 Tails in Chromatin Modulates Their Acetylation by P300/CBP-associated Factor J. Biol. Chem., April 21, 2000; 275(17): 12994 - 12999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Harrod, Y.-L. Kuo, Y. Tang, Y. Yao, A. Vassilev, Y. Nakatani, and C.-Z. Giam p300 and p300/cAMP-responsive Element-binding Protein Associated Factor Interact with Human T-cell Lymphotropic Virus Type-1 Tax in a Multi-histone Acetyltransferase/Activator-Enhancer Complex J. Biol. Chem., April 14, 2000; 275(16): 11852 - 11857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Herrera, K. L. West, R. L. Schiltz, Y. Nakatani, and M. Bustin Histone H1 Is a Specific Repressor of Core Histone Acetylation in Chromatin Mol. Cell. Biol., January 15, 2000; 20(2): 523 - 529. [Abstract] [Full Text]
|
|
|
|
|
|
H. Jiang, H. Lu, R. L. Schiltz, C. A. Pise-Masison, V. V. Ogryzko, Y. Nakatani, and J. N. Brady PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner Mol. Cell. Biol., December 1, 1999; 19(12): 8136 - 8145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Hsieh, T. K. Kundu, Z. Wang, R. Kovelman, and R. G. Roeder The TFIIIC90 Subunit of TFIIIC Interacts with Multiple Components of the RNA Polymerase III Machinery and Contains a Histone-Specific Acetyltransferase Activity Mol. Cell. Biol., November 1, 1999; 19(11): 7697 - 7704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ohba, D. J. Steger, J. E. Brownell, C. A. Mizzen, R. G. Cook, J. Cote, J. L. Workman, and C. D. Allis A Novel H2A/H4 Nucleosomal Histone Acetyltransferase in Tetrahymena thermophila Mol. Cell. Biol., March 1, 1999; 19(3): 2061 - 2068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fu, C. Wang, A. T. Reutens, J. Wang, R. H. Angeletti, L. Siconolfi-Baez, V. Ogryzko, M.-L. Avantaggiati, and R. G. Pestell p300 and p300/cAMP-response Element-binding Protein-associated Factor Acetylate the Androgen Receptor at Sites Governing Hormone-dependent Transactivation J. Biol. Chem., June 30, 2000; 275(27): 20853 - 20860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. D. Lau, A. D. Courtney, A. Vassilev, L. A. Marzilli, R. J. Cotter, Y. Nakatani, and P. A. Cole p300/CBP-associated Factor Histone Acetyltransferase Processing of a Peptide Substrate. KINETIC ANALYSIS OF THE CATALYTIC MECHANISM J. Biol. Chem., July 14, 2000; 275(29): 21953 - 21959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Polesskaya, A. Duquet, I. Naguibneva, C. Weise, A. Vervisch, E. Bengal, F. Hucho, P. Robin, and A. Harel-Bellan CREB-binding Protein/p300 Activates MyoD by Acetylation J. Biol. Chem., October 27, 2000; 275(44): 34359 - 34364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mizuguchi, A. Vassilev, T. Tsukiyama, Y. Nakatani, and C. Wu ATP-dependent Nucleosome Remodeling and Histone Hyperacetylation Synergistically Facilitate Transcription of Chromatin J. Biol. Chem., April 27, 2001; 276(18): 14773 - 14783. [Abstract] [Full Text] [PDF]
|
|
