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J Biol Chem, Vol. 274, Issue 3, 1458-1464, January 15, 1999
From the Boston University School of Medicine,
Boston, Massachusetts 02118
Glut4-containing vesicles immunoadsorbed from
primary rat adipocytes possess endogenous protein kinase activity and
phosphorylation substrates. Phosphorylation of several vesicle proteins
including Glut4 itself is rapidly activated by insulin. Wortmannin
blocks the effect of insulin when added to cells in vivo
prior to insulin administration. By means of MonoQ chromatography and
Western blot analysis, vesicle-associated protein kinase is identified
as Akt-2, a lipid-binding protein kinase involved in insulin signaling. Akt-2 is found to be recruited to Glut4-containing vesicles in response
to insulin.
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