| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 30, 21464-21470, July 23, 1999
From the Department of Viral Oncology, Institute for Virus
Research, Kyoto University, Sakyo-Ku, Kyoto 606-8507, Japan
The dishevelled (dsh)
gene family encodes cytoplasmic proteins that have been implicated in
Wnt/Wingless (Wg) signaling. To demonstrate functional conservation of
Dsh family proteins, two mouse homologs of Drosophila Dsh,
Dvl-1 and Dvl-2, were biochemically characterized in mouse and
Drosophila cell culture systems. We found that treatment
with a soluble Wnt-3A leads to hyperphosphorylation of Dvl proteins and
a concomitant elevation of the cytoplasmic
Characterization of Mouse Dishevelled (Dvl) Proteins in
Wnt/Wingless Signaling Pathway
-catenin levels in mouse
NIH3T3, L, and C57MG cells. This coincides well with our finding in a
Drosophila wing disc cell line, clone-8, that Wg treatment
induced hyperphosphorylation of Dsh (Yanagawa, S., van Leeuwen, F.,
Wodarz, A., Klingensmith, J., and Nusse, R. (1995) Genes
Dev. 9, 1087-1097). Furthermore, we showed that mouse Dvl
proteins affect downstream components of Drosophila Wg
signaling as Dsh does; overexpression of Dvl proteins in clone-8 cells
results in elevation of Armadillo (Drosophila homolog of -catenin) and Drosophila E-cadherin levels,
hyperphosphorylation of Dvl proteins themselves, and inhibition of
Zeste-White3 kinase-mediated phosphorylation of a microtubule-binding
protein, Tau. In addition, casein kinase II was shown to
coimmunoprecipitate with Dvl proteins, and Dvl proteins were
phosphorylated in these immune complexes. These results are direct
evidence that Dsh family proteins mediate a set of conserved
biochemical processes in the Wnt/Wg signaling pathway.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  F.-S. Chou, P.-S. Wang, S. Kulp, and J. J. Pinzone Effects of Thiazolidinediones on Differentiation, Proliferation, and Apoptosis Mol. Cancer Res., June 1, 2007; 5(6): 523 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wei, C. Yokota, M. V. Semenov, B. Doble, J. Woodgett, and X. He R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and beta-Catenin Signaling J. Biol. Chem., May 25, 2007; 282(21): 15903 - 15911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. V. Hojilla, I. Kim, Z. Kassiri, J. E. Fata, H. Fang, and R. Khokha Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3 J. Cell Sci., March 15, 2007; 120(6): 1050 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bryja, G. Schulte, N. Rawal, A. Grahn, and E. Arenas Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism J. Cell Sci., February 15, 2007; 120(4): 586 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Nemeth, M. R. Kirby, and D. M. Bodine Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation PNAS, September 12, 2006; 103(37): 13783 - 13788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Price CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes & Dev., February 15, 2006; 20(4): 399 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Wallingford and R. Habas The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity Development, October 15, 2005; 132(20): 4421 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Armstrong and K. A. Esser Wnt/{beta}-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy Am J Physiol Cell Physiol, October 1, 2005; 289(4): C853 - C859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-M. Xu, Y.-Q. Zhou, and M.-H. Wang Mechanisms of Cytoplasmic {beta}-Catenin Accumulation and Its Involvement in Tumorigenic Activities Mediated by Oncogenic Splicing Variant of the Receptor Originated from Nantes Tyrosine Kinase J. Biol. Chem., July 1, 2005; 280(26): 25087 - 25094. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tickenbrock, J. Schwable, M. Wiedehage, B. Steffen, B. Sargin, C. Choudhary, C. Brandts, W. E. Berdel, C. Muller-Tidow, and H. Serve Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction Blood, May 1, 2005; 105(9): 3699 - 3706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-S. Yun, S.-E. Kim, S. H. Jeon, J.-S. Lee, and K.-Y. Choi Both ERK and Wnt/{beta}-catenin pathways are involved in Wnt3a-induced proliferation J. Cell Sci., January 15, 2005; 118(2): 313 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Endo, V. Wolf, K. Muraiso, K. Kamijo, L. Soon, A. Uren, M. Barshishat-Kupper, and J. S. Rubin Wnt-3a-dependent Cell Motility Involves RhoA Activation and Is Specifically Regulated by Dishevelled-2 J. Biol. Chem., January 7, 2005; 280(1): 777 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Waxman, A. M. Hocking, C. L. Stoick, and R. T. Moon Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes Development, December 1, 2004; 131(23): 5909 - 5921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Gonzalez-Sancho, K. R. Brennan, L. A. Castelo-Soccio, and A. M. C. Brown Wnt Proteins Induce Dishevelled Phosphorylation via an LRP5/6- Independent Mechanism, Irrespective of Their Ability To Stabilize {beta}-Catenin Mol. Cell. Biol., June 1, 2004; 24(11): 4757 - 4768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsubayashi, S. Sese, J.-S. Lee, T. Shirakawa, T. Iwatsubo, T. Tomita, and S.-i. Yanagawa Biochemical Characterization of the Drosophila Wingless Signaling Pathway Based on RNA Interference Mol. Cell. Biol., March 1, 2004; 24(5): 2012 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Chen, D. ten Berge, J. Brown, S. Ahn, L. A. Hu, W. E. Miller, M. G. Caron, L. S. Barak, R. Nusse, and R. J. Lefkowitz Dishevelled 2 Recruits {beta}-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4 Science, September 5, 2003; 301(5638): 1391 - 1394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Hino, T. Michiue, M. Asashima, and A. Kikuchi Casein Kinase Iepsilon Enhances the Binding of Dvl-1 to Frat-1 and Is Essential for Wnt-3a-induced Accumulation of beta -Catenin J. Biol. Chem., April 11, 2003; 278(16): 14066 - 14073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rousset, K. A. Wharton Jr., G. Zimmermann, and M. P. Scott Zinc-dependent Interaction between Dishevelled and the Drosophila Wnt Antagonist Naked Cuticle J. Biol. Chem., December 6, 2002; 277(50): 49019 - 49026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Karasawa, H. Yokokura, J. Kitajewski, and P. J. Lombroso Frizzled-9 Is Activated by Wnt-2 and Functions in Wnt/beta -Catenin Signaling J. Biol. Chem., September 27, 2002; 277(40): 37479 - 37486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ishigaki, H. Namba, M. Nakashima, T. Nakayama, N. Mitsutake, T. Hayashi, S. Maeda, M. Ichinose, T. Kanematsu, and S. Yamashita Aberrant Localization of {beta}-Catenin Correlates with Overexpression of Its Target Gene in Human Papillary Thyroid Cancer J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3433 - 3440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Amit, A. Hatzubai, Y. Birman, J. S. Andersen, E. Ben-Shushan, M. Mann, Y. Ben-Neriah, and I. Alkalay Axin-mediated CKI phosphorylation of beta -catenin at Ser 45: a molecular switch for the Wnt pathway Genes & Dev., May 1, 2002; 16(9): 1066 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Briggs, Z. Li, and D. B. Sacks IQGAP1-mediated Stimulation of Transcriptional Co-activation by beta -Catenin Is Modulated by Calmodulin J. Biol. Chem., February 22, 2002; 277(9): 7453 - 7465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, L. A. Hu, M. V. Semenov, S. Yanagawa, A. Kikuchi, R. J. Lefkowitz, and W. E. Miller beta -Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins PNAS, December 6, 2001; (2001) 211572798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Bachmanov, X. Li, D. R. Reed, J. D. Ohmen, S. Li, Z. Chen, M. G. Tordoff, P. J. de Jong, C. Wu, D. B. West, et al. Positional Cloning of the Mouse Saccharin Preference (Sac) Locus Chem Senses, September 1, 2001; 26(7): 925 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mudher, S. Chapman, J. Richardson, A. Asuni, G. Gibb, C. Pollard, R. Killick, T. Iqbal, L. Raymond, I. Varndell, et al. Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase J. Neurosci., July 15, 2001; 21(14): 4987 - 4995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Hino, S. Kishida, T. Michiue, A. Fukui, I. Sakamoto, S. Takada, M. Asashima, and A. Kikuchi Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein Mol. Cell. Biol., January 1, 2001; 21(1): 330 - 342. [Abstract] [Full Text]
|
|
|
|
|
|
P. Polakis Wnt signaling and cancer Genes & Dev., August 1, 2000; 14(15): 1837 - 1851. [Full Text]
|
|
|
|
 |
|
 M. A. Torres and W. J. Nelson Colocalization and Redistribution of Dishevelled and Actin during Wnt-induced Mesenchymal Morphogenesis J. Cell Biol., June 26, 2000; 149(7): 1433 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Strovel, D. Wu, and D. J. Sussman Protein Phosphatase 2Calpha Dephosphorylates Axin and Activates LEF-1-dependent Transcription J. Biol. Chem., January 28, 2000; 275(4): 2399 - 2403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Zhurinsky, M Shtutman, and A Ben-Ze'ev Plakoglobin and beta-catenin: protein interactions, regulation and biological roles J. Cell Sci., January 9, 2000; 113(18): 3127 - 3139. [Abstract] [PDF]
|
|
|
|
|
|
C Hartmann and C. Tabin Dual roles of Wnt signaling during chondrogenesis in the chicken limb Development, January 7, 2000; 127(14): 3141 - 3159. [Abstract] [PDF]
|
|
|
|
|
|
S. Fukumoto, C.-M. Hsieh, K. Maemura, M. D. Layne, S.-F. Yet, K.-H. Lee, T. Matsui, A. Rosenzweig, W. G. Taylor, J. S. Rubin, et al. Akt Participation in the Wnt Signaling Pathway through Dishevelled J. Biol. Chem., May 11, 2001; 276(20): 17479 - 17483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kishida, S.-i. Hino, T. Michiue, H. Yamamoto, S. Kishida, A. Fukui, M. Asashima, and A. Kikuchi Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iepsilon J. Biol. Chem., August 24, 2001; 276(35): 33147 - 33155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cai, M. S. Lechner, D. Nihalani, M. J. Prindle, L. B. Holzman, and G. R. Dressler Phosphorylation of Pax2 by the c-Jun N-terminal Kinase and Enhanced Pax2-dependent Transcription Activation J. Biol. Chem., January 4, 2002; 277(2): 1217 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Song, D. J. Sussman, and D. C. Seldin Endogenous Protein Kinase CK2 Participates in Wnt Signaling in Mammary Epithelial Cells J. Biol. Chem., July 28, 2000; 275(31): 23790 - 23797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, L. A. Hu, M. V. Semenov, S. Yanagawa, A. Kikuchi, R. J. Lefkowitz, and W. E. Miller beta -Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins PNAS, December 18, 2001; 98(26): 14889 - 14894. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
