| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 31, 21645-21650, July 30, 1999
From the Department of Biological Responses, Institute for Virus
Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan
Recent works have shown the importance of
reduction/oxidation (redox) regulation in various biological phenomena.
Thioredoxin (TRX) is one of the major components of the thiol reducing
system and plays multiple roles in cellular processes such as
proliferation, apoptosis, and gene expression. To investigate the
molecular mechanism of TRX action, we used a yeast two-hybrid system to
identify TRX-binding proteins. One of the candidates, designated as
thioredoxin-binding protein-2 (TBP-2), was identical to vitamin
D3 up-regulated protein 1 (VDUP1). The association of
TRX with TBP-2/VDUP1 was observed in vitro and in
vivo. TBP-2/VDUP1 bound to reduced TRX but not to oxidized TRX
nor to mutant TRX, in which two redox active cysteine residues are
substituted by serine. Thus, the catalytic center of TRX seems to be
important for the interaction. Insulin reducing activity of TRX was
inhibited by the addition of recombinant TBP-2/VDUP1 protein in
vitro. In COS-7 and HEK293 cells transiently transfected with
TBP-2/VDUP1 expression vector, decrease of insulin reducing activity of
TRX and diminishment of TRX expression was observed. These results
suggested that TBP-2/VDUP1 serves as a negative regulator of the
biological function and expression of TRX. Treatment of HL-60 cells
with 1
,25-dihydroxyvitamin D3 caused an increase of
TBP-2/VDUP1 expression and down-regulation of the expression and the
reducing activity of TRX. Therefore, the TRX-TBP-2/VDUP1 interaction
may be an important redox regulatory mechanism in cellular processes,
including differentiation of myeloid and macrophage lineages.
This article has been cited by other articles:
|
|
 |
|
  C.-L. Chen, C.-F. Lin, W.-T. Chang, W.-C. Huang, C.-F. Teng, and Y.-S. Lin Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway Blood, April 15, 2008; 111(8): 4365 - 4374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Corbett Thioredoxin-Interacting Protein Is Killing My {beta}-cells! Diabetes, April 1, 2008; 57(4): 797 - 798. [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, G. Saxena, I. N. Mungrue, A. J. Lusis, and A. Shalev Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and {beta}-Cell Apoptosis Diabetes, April 1, 2008; 57(4): 938 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Y. Hui, A. M. Andres, A. K. Miller, N. J. Spann, D. W. Potter, N. M. Post, A. Z. Chen, S. Sachithanantham, D. Y. Jung, J. K. Kim, et al. Txnip balances metabolic and growth signaling via PTEN disulfide reduction PNAS, March 11, 2008; 105(10): 3921 - 3926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Chutkow, P. Patwari, J. Yoshioka, and R. T. Lee Thioredoxin-interacting Protein (Txnip) Is a Critical Regulator of Hepatic Glucose Production J. Biol. Chem., January 25, 2008; 283(4): 2397 - 2406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Davis Searching for Causality of Knocking Out Txnip: Is Txnip Missing in Action? Circ. Res., December 7, 2007; 101(12): 1216 - 1218. [Full Text] [PDF]
|
|
|
|
 |
|
 W. Qi, X. Chen, R. E. Gilbert, Y. Zhang, M. Waltham, M. Schache, D. J. Kelly, and C. A. Pollock High Glucose-Induced Thioredoxin-Interacting Protein in Renal Proximal Tubule Cells Is Independent of Transforming Growth Factor-{beta}1 Am. J. Pathol., September 1, 2007; 171(3): 744 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Turturro, G. Von Burton, and E. Friday Hyperglycemia-Induced Thioredoxin-Interacting Protein Expression Differs in Breast Cancer-Derived Cells and Regulates Paclitaxel IC50 Clin. Cancer Res., June 15, 2007; 13(12): 3724 - 3730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hamada, S. Miyata, T. Nii-Kono, R. Kitazawa, S. Kitazawa, S. Higo, M. Fukunaga, S. Ueyama, H. Nakamura, J. Yodoi, et al. Overexpression of thioredoxin1 in transgenic mice suppresses development of diabetic nephropathy Nephrol. Dial. Transplant., June 1, 2007; 22(6): 1547 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kobayashi-Miura, K. Shioji, Y. Hoshino, H. Masutani, H. Nakamura, and J. Yodoi Oxygen sensing and redox signaling: the role of thioredoxin in embryonic development and cardiac diseases Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2040 - H2050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Berndt, C. H. Lillig, and A. Holmgren Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1227 - H1236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Liang and J. L. Pietrusz Thiol-Related Genes in Diabetic Complications: A Novel Protective Role for Endogenous Thioredoxin 2 Arterioscler. Thromb. Vasc. Biol., January 1, 2007; 27(1): 77 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K.C. Ng, J. Wu, E. Chang, B.-y. Wang, R. Katzenberg-Clark, A. Ishii-Watabe, and J. P. Cooke A Central Role for Nicotinic Cholinergic Regulation of Growth Factor-Induced Endothelial Cell Migration Arterioscler. Thromb. Vasc. Biol., January 1, 2007; 27(1): 106 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Schulze, H. Liu, E. Choe, J. Yoshioka, A. Shalev, K. D. Bloch, and R. T. Lee Nitric Oxide-Dependent Suppression of Thioredoxin-Interacting Protein Expression Enhances Thioredoxin Activity Arterioscler. Thromb. Vasc. Biol., December 1, 2006; 26(12): 2666 - 2672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Xu, L. Ngo, G. Perez, M. Dokmanovic, and P. A. Marks Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitor PNAS, October 17, 2006; 103(42): 15540 - 15545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Patwari, L. J. Higgins, W. A. Chutkow, J. Yoshioka, and R. T. Lee The Interaction of Thioredoxin with Txnip: EVIDENCE FOR FORMATION OF A MIXED DISULFIDE BY DISULFIDE EXCHANGE J. Biol. Chem., August 4, 2006; 281(31): 21884 - 21891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Oka, H. Masutani, W. Liu, H. Horita, D. Wang, S. Kizaka-Kondoh, and J. Yodoi Thioredoxin-Binding Protein-2-Like Inducible Membrane Protein Is a Novel Vitamin D3 and Peroxisome Proliferator-Activated Receptor (PPAR){gamma} Ligand Target Protein that Regulates PPAR{gamma} Signaling Endocrinology, February 1, 2006; 147(2): 733 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Filby, S. B. Hooper, F. Sozo, V. A. Zahra, S. J. Flecknoe, and M. J. Wallace VDUP1: a potential mediator of expansion-induced lung growth and epithelial cell differentiation in the ovine fetus Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L250 - L258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. YOSHIDA, H. NAKAMURA, H. MASUTANI, and J. YODOI The Involvement of Thioredoxin and Thioredoxin Binding Protein-2 on Cellular Proliferation and Aging Process Ann. N.Y. Acad. Sci., December 1, 2005; 1055(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vignols, C. Brehelin, Y. Surdin-Kerjan, D. Thomas, and Y. Meyer A yeast two-hybrid knockout strain to explore thioredoxin-interacting proteins in vivo PNAS, November 15, 2005; 102(46): 16729 - 16734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Tome, D. B. F. Johnson, L. M. Rimsza, R. A. Roberts, T. M. Grogan, T. P. Miller, L. W. Oberley, and M. M. Briehl A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis Blood, November 15, 2005; 106(10): 3594 - 3601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Moon, M. R. Fernando, and M. F. Lou Induction of Thioltransferase and Thioredoxin/Thioredoxin Reductase Systems in Cultured Porcine Lenses under Oxidative Stress Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3783 - 3789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fratelli, L. O. Goodwin, U. A. Orom, S. Lombardi, R. Tonelli, M. Mengozzi, and P. Ghezzi Gene expression profiling reveals a signaling role of glutathione in redox regulation PNAS, September 27, 2005; 102(39): 13998 - 14003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Song, J. L. Barth, Y. Yu, K. Lu, A. Dashti, Y. Huang, C. K. Gittinger, W. S. Argraves, and T. J. Lyons Effects of Oxidized and Glycated LDL on Gene Expression in Human Retinal Capillary Pericytes Invest. Ophthalmol. Vis. Sci., August 1, 2005; 46(8): 2974 - 2982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Y. LIN, K B CHEN, and P L CHAO Antioxidative Effect of Vitamin D3 on Zinc-Induced Oxidative Stress in CNS Ann. N.Y. Acad. Sci., August 1, 2005; 1053(1): 319 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Jeon, K.-N. Lee, C. Y. Hwang, K.-S. Kwon, K.-H. You, and I. Choi Tumor Suppressor VDUP1 Increases p27kip1 Stability by Inhibiting JAB1 Cancer Res., June 1, 2005; 65(11): 4485 - 4489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Minn, C. Hafele, and A. Shalev Thioredoxin-Interacting Protein Is Stimulated by Glucose through a Carbohydrate Response Element and Induces {beta}-Cell Apoptosis Endocrinology, May 1, 2005; 146(5): 2397 - 2405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Sheth, L. W. Castellani, S. Chari, C. Wagg, C. K. Thipphavong, J. S. Bodnar, P. Tontonoz, A. D. Attie, G. D. Lopaschuk, and A. J. Lusis Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition J. Lipid Res., January 1, 2005; 46(1): 123 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Deroo, S. C. Hewitt, S. D. Peddada, and K. S. Korach Estradiol Regulates the Thioredoxin Antioxidant System in the Mouse Uterus Endocrinology, December 1, 2004; 145(12): 5485 - 5492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Lowenstein Exogenous Thioredoxin Reduces Inflammation in Autoimmune Myocarditis Circulation, September 7, 2004; 110(10): 1178 - 1179. [Full Text] [PDF]
|
|
|
|
|
|
W. Liu, H. Nakamura, K. Shioji, M. Tanito, S.-i. Oka, M. K. Ahsan, A. Son, Y. Ishii, C. Kishimoto, and J. Yodoi Thioredoxin-1 Ameliorates Myosin-Induced Autoimmune Myocarditis by Suppressing Chemokine Expressions and Leukocyte Chemotaxis in Mice Circulation, September 7, 2004; 110(10): 1276 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishinaka, H. Masutani, S.-i. Oka, Y. Matsuo, Y. Yamaguchi, K. Nishio, Y. Ishii, and J. Yodoi Importin {alpha}1 (Rch1) Mediates Nuclear Translocation of Thioredoxin-binding Protein-2/Vitamin D3-up-regulated Protein 1 J. Biol. Chem., September 3, 2004; 279(36): 37559 - 37565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Schulze, J. Yoshioka, T. Takahashi, Z. He, G. L. King, and R. T. Lee Hyperglycemia Promotes Oxidative Stress through Inhibition of Thioredoxin Function by Thioredoxin-interacting Protein J. Biol. Chem., July 16, 2004; 279(29): 30369 - 30374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Y. Hui, S. S. Sheth, J. M. Diffley, D. W. Potter, A. J. Lusis, A. D. Attie, and R. A. Davis Mice Lacking Thioredoxin-interacting Protein Provide Evidence Linking Cellular Redox State to Appropriate Response to Nutritional Signals J. Biol. Chem., June 4, 2004; 279(23): 24387 - 24393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.E. Hoei-Hansen, J.E. Nielsen, K. Almstrup, M.A. Hansen, N.E. Skakkebaek, E. Rajpert-DeMeyts, and H. Leffers Identification of genes differentially expressed in testes containing carcinoma in situ Mol. Hum. Reprod., June 1, 2004; 10(6): 423 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yoshioka, P. C. Schulze, M. Cupesi, J. D. Sylvan, C. MacGillivray, J. Gannon, H. Huang, and R. T. Lee Thioredoxin-Interacting Protein Controls Cardiac Hypertrophy Through Regulation of Thioredoxin Activity Circulation, June 1, 2004; 109(21): 2581 - 2586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G Simmons and T. G Kennedy Rat endometrial Vdup1 expression: changes related to sensitization for the decidual cell reaction and hormonal control Reproduction, April 1, 2004; 127(4): 475 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishinaka, A. Nishiyama, H. Masutani, S.-i. Oka, K. Md. Ahsan, Y. Nakayama, Y. Ishii, H. Nakamura, M. Maeda, and J. Yodoi Loss of Thioredoxin-Binding Protein-2/Vitamin D3 Up-Regulated Protein 1 in Human T-Cell Leukemia Virus Type I-Dependent T-Cell Transformation: Implications for Adult T-Cell Leukemia Leukemogenesis Cancer Res., February 15, 2004; 64(4): 1287 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Jeong, H. W. Yoon, S.-R. Lee, and S. G. Rhee Identification and Characterization of TRP14, a Thioredoxin-related Protein of 14 kDa: NEW INSIGHTS INTO THE SPECIFICITY OF THIOREDOXIN FUNCTION J. Biol. Chem., January 30, 2004; 279(5): 3142 - 3150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Tulman, C. L. Afonso, Z. Lu, L. Zsak, G. F. Kutish, and D. L. Rock The Genome of Canarypox Virus J. Virol., January 1, 2004; 78(1): 353 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamawaki, J. Haendeler, and B. C. Berk Thioredoxin: A Key Regulator of Cardiovascular Homeostasis Circ. Res., November 28, 2003; 93(11): 1029 - 1033. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Takahashi, Y. Ishii, A. Murata, T. Nagata, and S. Asai Localization of Thioredoxin-interacting Protein (TXNIP) mRNA in Epithelium of Human Gastrointestinal Tract J. Histochem. Cytochem., July 1, 2003; 51(7): 973 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Singha, A. Vlamis-Gardikas, and A. Holmgren Real-time Kinetics of the Interaction between the Two Subunits, Escherichia coli Thioredoxin and Gene 5 Protein of Phage T7 DNA Polymerase J. Biol. Chem., June 6, 2003; 278(24): 21421 - 21428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Roberts, M. A. Zandonatti, D. D. Watry, L. J. Madden, S. J. Henriksen, M. A. Taffe, and H. S. Fox Induction of Pathogenic Sets of Genes in Macrophages and Neurons in NeuroAIDS Am. J. Pathol., June 1, 2003; 162(6): 2041 - 2057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Goldberg, M. E. Miele, N. Hatta, M. Takata, C. Paquette-Straub, L. P. Freedman, and D. R. Welch Melanoma Metastasis Suppression by Chromosome 6: Evidence for a Pathway Regulated by CRSP3 and TXNIP Cancer Res., January 15, 2003; 63(2): 432 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bai, H. Nakamura, Y.-W. Kwon, I. Hattori, Y. Yamaguchi, Y.-C. Kim, N. Kondo, S.-i. Oka, S. Ueda, H. Masutani, et al. Critical Roles of Thioredoxin in Nerve Growth Factor-Mediated Signal Transduction and Neurite Outgrowth in PC12 Cells J. Neurosci., January 15, 2003; 23(2): 503 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wan and S. K. Nordeen Overlapping but Distinct Profiles of Gene Expression Elicited by Glucocorticoids and Progestins Recent Prog. Horm. Res., January 1, 2003; 58(1): 199 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Schulze, G. W. De Keulenaer, J. Yoshioka, K. A. Kassik, and R. T. Lee Vitamin D3-Upregulated Protein-1 (VDUP-1) Regulates Redox-Dependent Vascular Smooth Muscle Cell Proliferation Through Interaction With Thioredoxin Circ. Res., October 18, 2002; 91(8): 689 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Butler, X. Zhou, W.-S. Xu, H. I. Scher, R. A. Rifkind, P. A. Marks, and V. M. Richon The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin PNAS, September 3, 2002; 99(18): 11700 - 11705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, G. W. De Keulenaer, and R. T. Lee Vitamin D3-up-regulated Protein-1 Is a Stress-responsive Gene That Regulates Cardiomyocyte Viability through Interaction with Thioredoxin J. Biol. Chem., July 12, 2002; 277(29): 26496 - 26500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wan and S. K. Nordeen Overlapping but Distinct Gene Regulation Profiles by Glucocorticoids and Progestins in Human Breast Cancer Cells Mol. Endocrinol., June 1, 2002; 16(6): 1204 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. HIROTA, H. NAKAMURA, H. MASUTANI, and J. YODOI Thioredoxin Superfamily and Thioredoxin-Inducing Agents Ann. N.Y. Acad. Sci., May 1, 2002; 957(1): 189 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Junn, S. H. Han, J. Y. Im, Y. Yang, E. W. Cho, H. D. Um, D. K. Kim, K. W. Lee, P. L. Han, S. G. Rhee, et al. Vitamin D3 Up-Regulated Protein 1 Mediates Oxidative Stress Via Suppressing the Thioredoxin Function J. Immunol., June 15, 2000; 164(12): 6287 - 6295. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
