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J Biol Chem, Vol. 274, Issue 31, 22053-22059, July 30, 1999
From the This paper reports the identification of two
structural variations in the NC1 domain of rat and mouse type XII
collagen. The long NC1 domain encoding 74 amino acids showed homology
to chicken type XII and XIV collagens. The short NC1 domain was
composed of 19 amino acids. Through genomic DNA analyses, two
alternative exons were identified, each of which contained the variable
NC1 sequence. With the amino-terminal NC3 splicing alternatives, we propose here a new descriptive nomenclature: types XIIA-1 and XIIB-1
which include a long NC1 sequence encoded by exon 1 (from the 3'-end),
and types XIIA-2 and XIIB-2 which include a short NC1 sequence encoded
by exon 2. Types XIIA-1 and XIIB-1, the predominant transcripts in
15-day old mouse embryos, showed decreased expression in 17-day old
embryos when type XIIB-2 expression was sustained at constant levels.
In adult mice, type XIIB-1 associates with ligament and tendon, whereas
type XIIB-2 is expressed in various other tissues. The long NC1 domain
contains an extended acidic region (pI = 3.4) followed by a
terminal basic region (pI = 13.8). Because the short NC1 domain
lacks these features, structural variations in the type XII collagen
NC1 domain suggests different functional roles in a tissue-specific fashion.
Structural Variation of Type XII Collagen at Its
Carboxyl-terminal NC1 Domain Generated by Tissue-specific Alternative
Splicing
,,
Department of Periodontology, Harvard School
of Dental Medicine, Boston, Massachusetts, 02115, the
§ Department Cell Biology, Harvard Medical School, Boston,
Massachusetts, 02115, the ¶ Department of Orthodontics, University
of Alabama at Birmingham School of Dentistry, Birmingham, Alabama
35213, and The Jane and Jerry Weintraub Center for
Reconstructive Biotechnology, Division of Advanced Prosthodontics,
Biomaterials and Hospital Dentistry, UCLA School of Dentistry,
Los Angeles, California 90095
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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