| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 32, 22493-22501, August 6, 1999
From the Department of Physiology, University of British Columbia,
Vancouver V6T 1Z3, Canada
Two of the most effective stimuli of gastrin
release from human antral G cells are bombesin and phorbol esters. Both
agonists result in activation of the protein kinase C family of
isozymes, however, the exact contribution of protein kinase C to the
resultant release of gastrin has been difficult to assess, possibly due to the presence of multiple protein kinase C isozymes in the G cells.
The results of the present study demonstrated that the human antral G
cells expressed 6 protein kinase C isozymes 
, 
, 
, 
, 
,
and µ. Of these protein kinase C, and were translocated by
stimulation of the cells by either 10 nM bombesin or
1 nM phorbol ester. Inhibition of protein kinase Cµ
(localized to the Golgi complex) did not decrease bombesin-stimulated
gastrin release indicating that this isozyme was not involved in the
secretory process. The use of selective antagonists of the
calcium-sensitive conventional protein kinase C subgroup resulted in an
increase in bombesin-stimulated gastrin release and indicated that
protein kinase C was involved in the desensitization of the bombesin response.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Li, L. A. Chen, C. M. Townsend Jr., and B. M. Evers PKD1, PKD2, and Their Substrate Kidins220 Regulate Neurotensin Secretion in the BON Human Endocrine Cell Line J. Biol. Chem., February 1, 2008; 283(5): 2614 - 2621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Li and B. M. Wice Bombesin and nutrients independently and additively regulate hormone release from GIP/Ins cells Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E208 - E215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, K. L. O'Connor, M. R. Hellmich, G. H. Greeley Jr., C. M. Townsend Jr., and B. M. Evers The Role of Protein Kinase D in Neurotensin Secretion Mediated by Protein Kinase C-{alpha}/-{delta} and Rho/Rho Kinase J. Biol. Chem., July 2, 2004; 279(27): 28466 - 28474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, M. R. Hellmich, G. H. Greeley Jr., C. M. Townsend Jr., and B. M. Evers Phorbol ester-mediated neurotensin secretion is dependent on the PKC-alpha and -delta isoforms Am J Physiol Gastrointest Liver Physiol, November 1, 2002; 283(5): G1197 - G1206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H L Waldum, A K Sandvik, P Hildebrand, and C Beglinger GRP and stimulation of acid secretion Gut, August 1, 2002; 51(2): 297 - 298. [Full Text] [PDF]
|
|
|
|
 |
|
 C.-J. Tai, S. K. Kang, K.-C. Choi, C.-R. Tzeng, and P. C. K. Leung Antigonadotropic Action of Adenosine Triphosphate in Human Granulosa-Luteal Cells: Involvement of Protein Kinase C{{alpha}} J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3237 - 3242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Matthews, E. Rozengurt, and D. Cantrell Protein Kinase D: A Selective Target for Antigen Receptors and a Downstream Target for Protein Kinase C in Lymphocytes J. Exp. Med., June 12, 2000; 191(12): 2075 - 2082. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
