| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 34, 23940-23947, August 20, 1999
,,,,,,,,
, and
From the We examined the actions of sphingosine
1-phosphate (S1P) on signaling pathways in Chinese hamster ovary cells
transfected with putative S1P receptor subtypes, i.e.
Edg-1, AGR16/H218 (Edg-5), and Edg-3. Among these receptor-transfected
cells, there was no significant difference in the expressing numbers of
the S1P receptors and their affinities to S1P, which were estimated by
[3H]S1P binding to the cells. In vector-transfected
cells, S1P slightly increased cytosolic Ca2+ concentration
([Ca2+]i) in association with inositol phosphate
production, reflecting phospholipase C activation; the S1P-induced
actions were markedly enhanced in the Edg-3-transfected cells and
moderately so in the AGR16-transfected cells. In comparison with
vector-transfected cells, the S1P-induced [Ca2+]i
increase was also slightly enhanced in the Edg-1-transfected cells. In
all cases, the inositol phosphate and Ca2+ responses to S1P
were partially inhibited by pertussis toxin (PTX). S1P also
significantly increased cAMP content in a PTX-insensitive manner in all
the transfected cells; the rank order of their intrinsic activity of
S1P receptor subtypes was AGR16 > Edg-3 > Edg-1. In the
presence of forskolin, however, S1P significantly inhibited cAMP
accumulation at a lower concentration (1-100 nM) of S1P in a manner sensitive to PTX in the Edg-1-transfected cells but not in
either the Edg-3 or AGR16-transfected cells. As for cell migration activity evaluated by cell number across the filter of blind Boyden chamber, Edg-1 and Edg-3 were equally potent, but AGR16 was
ineffective. Thus, S1P receptors may couple to both PTX-sensitive and
-insensitive G-proteins, resulting in the selective regulation of the
phospholipase C-Ca2+ system, adenylyl cyclase-cAMP system,
and cell migration activity, according to the receptor subtype.
Laboratory of Signal Transduction, Tokyo Metropolitan Institute of Medical
Science,
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
This article has been cited by other articles:
|
|
 |
|
  C. K. Means, S. Miyamoto, J. Chun, and J. H. Brown S1P1 Receptor Localization Confers Selectivity for Gi-mediated cAMP and Contractile Responses J. Biol. Chem., May 2, 2008; 283(18): 11954 - 11963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gorshkova, D. He, E. Berdyshev, P. Usatuyk, M. Burns, S. Kalari, Y. Zhao, S. Pendyala, J. G. N. Garcia, N. J. Pyne, et al. Protein Kinase C-{epsilon} Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2, Protein Kinase C-{zeta}, and Rac1 J. Biol. Chem., April 25, 2008; 283(17): 11794 - 11806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Damirin, H. Tomura, M. Komachi, J.-P. Liu, C. Mogi, M. Tobo, J.-Q. Wang, T. Kimura, A. Kuwabara, Y. Yamazaki, et al. Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2513 - H2522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I. Jiang, J. Collins, R. Davis, K.-M. Lin, D. DeCamp, T. Roach, R. Hsueh, R. A. Rebres, E. M. Ross, R. Taussig, et al. Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway J. Biol. Chem., April 6, 2007; 282(14): 10576 - 10584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-J. Jun, J.-H. Lee, B.-H. Choi, T.-K. Koh, D.-C. Ha, M.-W. Jeong, and K.-T. Kim Sphingosine-1-Phosphate Modulates Both Lipolysis and Leptin Production in Differentiated Rat White Adipocytes Endocrinology, December 1, 2006; 147(12): 5835 - 5844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. von Otte, J. R. J. Paletta, S. Becker, S. Konig, M. Fobker, R. R. Greb, L. Kiesel, G. Assmann, K. Diedrich, and J.-R. Nofer Follicular Fluid High Density Lipoprotein-associated Sphingosine 1-Phosphate Is a Novel Mediator of Ovarian Angiogenesis J. Biol. Chem., March 3, 2006; 281(9): 5398 - 5405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ozbay, A. Rowan, A. Leon, P. Patel, and M. B. Sewer Cyclic Adenosine 5'-Monophosphate-Dependent Sphingosine-1-Phosphate Biosynthesis Induces Human CYP17 Gene Transcription by Activating Cleavage of Sterol Regulatory Element Binding Protein 1 Endocrinology, March 1, 2006; 147(3): 1427 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Park, H.-Y. Lee, M.-K. Kim, E. H. Shin, S. H. Jo, S. D. Kim, D.-S. Im, and Y.-S. Bae Lysophosphatidylserine Stimulates L2071 Mouse Fibroblast Chemotactic Migration via a Process Involving Pertussis Toxin-Sensitive Trimeric G-Proteins Mol. Pharmacol., March 1, 2006; 69(3): 1066 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rahaman, R. W. Costello, K. E. Belmonte, S. S. Gendy, and M.-T. Walsh Neutrophil Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors in Pneumonia Am. J. Respir. Cell Mol. Biol., February 1, 2006; 34(2): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tomura, J.-Q. Wang, M. Komachi, A. Damirin, C. Mogi, M. Tobo, J. Kon, N. Misawa, K. Sato, and F. Okajima Prostaglandin I2 Production and cAMP Accumulation in Response to Acidic Extracellular pH through OGR1 in Human Aortic Smooth Muscle Cells J. Biol. Chem., October 14, 2005; 280(41): 34458 - 34464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Maghazachi Insights into Seven and Single Transmembrane-Spanning Domain Receptors and Their Signaling Pathways in Human Natural Killer Cells Pharmacol. Rev., September 1, 2005; 57(3): 339 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Damirin, H. Tomura, M. Komachi, M. Tobo, K. Sato, C. Mogi, H. Nochi, K. Tamoto, and F. Okajima Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells Mol. Pharmacol., April 1, 2005; 67(4): 1177 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Davis, J. J. Clemens, T. L. Macdonald, and K. R. Lynch Sphingosine 1-Phosphate Analogs as Receptor Antagonists J. Biol. Chem., March 18, 2005; 280(11): 9833 - 9841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Argraves, B. A. Wilkerson, W. S. Argraves, P. A. Fleming, L. M. Obeid, and C. J. Drake Sphingosine-1-phosphate Signaling Promotes Critical Migratory Events in Vasculogenesis J. Biol. Chem., November 26, 2004; 279(48): 50580 - 50590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Q. Wang, J. Kon, C. Mogi, M. Tobo, A. Damirin, K. Sato, M. Komachi, E. Malchinkhuu, N. Murata, T. Kimura, et al. TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor J. Biol. Chem., October 29, 2004; 279(44): 45626 - 45633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Gurok, C. Steinhoff, B. Lipkowitz, H.-H. Ropers, C. Scharff, and U. A. Nuber Gene Expression Changes in the Course of Neural Progenitor Cell Differentiation J. Neurosci., June 30, 2004; 24(26): 5982 - 6002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.-J. Hung, I.-W. J. Hsu, J. L. Dreiling, M.-J. Lee, C. A. Williams, M. D. Oberst, R. B. Dickson, and C.-Y. Lin Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1159 - C1169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gong, H. Wei, S. H. Chowdhury, and S. Chatterjee Lactosylceramide recruits PKC{alpha}/{epsilon} and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells PNAS, April 27, 2004; 101(17): 6490 - 6495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-S. Im Discovery of new G protein-coupled receptors for lipid mediators J. Lipid Res., March 1, 2004; 45(3): 410 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamada, K. Sato, M. Komachi, E. Malchinkhuu, M. Tobo, T. Kimura, A. Kuwabara, Y. Yanagita, T. Ikeya, Y. Tanahashi, et al. Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1 J. Biol. Chem., February 20, 2004; 279(8): 6595 - 6605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ishiwara, Y. Aoki, H. Takagaki, M. Ui, and F. Okajima TA-270 [4-Hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an Anti-Asthmatic Agent, Inhibits Leukotriene Production Induced by IgE Receptor Stimulation in RBL-2H3 Cells J. Pharmacol. Exp. Ther., November 1, 2003; 307(2): 583 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ohta, K. Sato, N. Murata, A. Damirin, E. Malchinkhuu, J. Kon, T. Kimura, M. Tobo, Y. Yamazaki, T. Watanabe, et al. Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors Mol. Pharmacol., October 1, 2003; 64(4): 994 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Waters, B. Sambi, K.-C. Kong, D. Thompson, S. M. Pitson, S. Pyne, and N. J. Pyne Sphingosine 1-Phosphate and Platelet-derived Growth Factor (PDGF) Act via PDGFbeta Receptor-Sphingosine 1-Phosphate Receptor Complexes in Airway Smooth Muscle Cells J. Biol. Chem., February 14, 2003; 278(8): 6282 - 6290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ishii, X. Ye, B. Friedman, S. Kawamura, J. J. A. Contos, M. A. Kingsbury, A. H. Yang, G. Zhang, J. H. Brown, and J. Chun Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3 J. Biol. Chem., July 5, 2002; 277(28): 25152 - 25159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. KOHNO, A. WADA, and Y. IGARASHI N-Glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization FASEB J, July 1, 2002; 16(9): 983 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Benaud, M. Oberst, J. P. Hobson, S. Spiegel, R. B. Dickson, and C.-Y. Lin Sphingosine 1-Phosphate, Present in Serum-derived Lipoproteins, Activates Matriptase J. Biol. Chem., March 15, 2002; 277(12): 10539 - 10546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Proenza, D. Angoli, E. Agranovich, V. Macri, and E. A. Accili Pacemaker Channels Produce an Instantaneous Current J. Biol. Chem., February 8, 2002; 277(7): 5101 - 5109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Okamoto, N. Takuwa, T. Yokomizo, N. Sugimoto, S. Sakurada, H. Shigematsu, and Y. Takuwa Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3 Mol. Cell. Biol., December 15, 2000; 20(24): 9247 - 9261. [Abstract] [Full Text]
|
|
|
|
|
|
H. M. Himmel, D. Meyer zu Heringdorf, E. Graf, D. Dobrev, A. Kortner, S. Schüler, K. H. Jakobs, and U. Ravens Evidence for Edg-3 Receptor-Mediated Activation of IK.ACh by Sphingosine-1-Phosphate in Human Atrial Cardiomyocytes Mol. Pharmacol., August 1, 2000; 58(2): 449 - 454. [Abstract] [Full Text]
|
|
|
|
|
|
D.-S. Im, C. E. Heise, N. Ancellin, B. F. O'Dowd, G.-j. Shei, R. P. Heavens, M. R. Rigby, T. Hla, S. Mandala, G. McAllister, et al. Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8 J. Biol. Chem., May 5, 2000; 275(19): 14281 - 14286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. AN Molecular Identification and Characterization of G Protein-Coupled Receptors for Lysophosphatidic Acid and Sphingosine 1-Phosphate Ann. N.Y. Acad. Sci., April 1, 2000; 905(1): 25 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. An, Y. Zheng, and T. Bleu Sphingosine 1-Phosphate-induced Cell Proliferation, Survival, and Related Signaling Events Mediated by G Protein-coupled Receptors Edg3 and Edg5 J. Biol. Chem., January 7, 2000; 275(1): 288 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Olivera, T. Kohama, L. Edsall, V. Nava, O. Cuvillier, S. Poulton, and S. Spiegel Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-phosphate and Promotes Cell Growth and Survival J. Cell Biol., November 1, 1999; 147(3): 545 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Malek, R. E. Toman, L. C. Edsall, S. Wong, J. Chiu, C. A. Letterle, J. R. Van Brocklyn, S. Milstien, S. Spiegel, and N. H. Lee Nrg-1 Belongs to the Endothelial Differentiation Gene Family of G Protein-coupled Sphingosine-1-phosphate Receptors J. Biol. Chem., February 16, 2001; 276(8): 5692 - 5699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Davaille, C. Gallois, A. Habib, L. Li, A. Mallat, J. Tao, T. Levade, and S. Lotersztajn Antiproliferative Properties of Sphingosine 1-Phosphate in Human Hepatic Myofibroblasts. A CYCLOOXYGENASE-2 MEDIATED PATHWAY J. Biol. Chem., October 27, 2000; 275(44): 34628 - 34633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Alderton, P. Darroch, B. Sambi, A. McKie, I. S. Ahmed, N. Pyne, and S. Pyne G-protein-coupled Receptor Stimulation of the p42/p44 Mitogen-activated Protein Kinase Pathway Is Attenuated by Lipid Phosphate Phosphatases 1, 1a, and 2 in Human Embryonic Kidney 293 Cells J. Biol. Chem., April 13, 2001; 276(16): 13452 - 13460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Young, M. D. Bootman, D. R. Channing, P. Lipp, P. R. Maycox, J. Meakin, R. A. J. Challiss, and S. R. Nahorski Lysophosphatidic Acid-induced Ca2+ Mobilization Requires Intracellular Sphingosine 1-Phosphate Production. POTENTIAL INVOLVEMENT OF ENDOGENOUS EDG-4 RECEPTORS J. Biol. Chem., December 1, 2000; 275(49): 38532 - 38539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Igarashi, S. G. Bernier, and T. Michel Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase. DIFFERENTIAL REGULATION OF Akt AND MAP KINASE PATHWAYS BY EDG AND BRADYKININ RECEPTORS IN VASCULAR ENDOTHELIAL CELLS J. Biol. Chem., April 6, 2001; 276(15): 12420 - 12426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Paik, S.-s. Chae, M.-J. Lee, S. Thangada, and T. Hla Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of alpha vbeta 3- and beta 1-containing Integrins J. Biol. Chem., April 6, 2001; 276(15): 11830 - 11837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Morales-Ruiz, M.-J. Lee, S. Zollner, J.-P. Gratton, R. Scotland, I. Shiojima, K. Walsh, T. Hla, and W. C. Sessa Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a Gi Protein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells J. Biol. Chem., May 25, 2001; 276(22): 19672 - 19677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Alderton, S. Rakhit, K. C. Kong, T. Palmer, B. Sambi, S. Pyne, and N. J. Pyne Tethering of the Platelet-derived Growth Factor beta Receptor to G-protein-coupled Receptors. A NOVEL PLATFORM FOR INTEGRATIVE SIGNALING BY THESE RECEPTOR CLASSES IN MAMMALIAN CELLS J. Biol. Chem., July 20, 2001; 276(30): 28578 - 28585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kimura, K. Sato, A. Kuwabara, H. Tomura, M. Ishiwara, I. Kobayashi, M. Ui, and F. Okajima Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells J. Biol. Chem., August 17, 2001; 276(34): 31780 - 31785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ishii, B. Friedman, X. Ye, S. Kawamura, C. McGiffert, J. J. A. Contos, M. A. Kingsbury, G. Zhang, J. H. Brown, and J. Chun Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3 J. Biol. Chem., August 31, 2001; 276(36): 33697 - 33704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Banno, Y. Takuwa, Y. Akao, H. Okamoto, Y. Osawa, T. Naganawa, S. Nakashima, P.-G. Suh, and Y. Nozawa Involvement of Phospholipase D in Sphingosine 1-Phosphate-induced Activation of Phosphatidylinositol 3-Kinase and Akt in Chinese Hamster Ovary Cells Overexpressing EDG3 J. Biol. Chem., September 14, 2001; 276(38): 35622 - 35628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Kluk and T. Hla Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration Circ. Res., September 14, 2001; 89(6): 496 - 502. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
