| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 34, 23996-24006, August 20, 1999
,,
,,
From the Intermediate filaments are general constituents
of the cytoskeleton. The function of these structures and the
requirement for different types of intermediate filament proteins by
individual cells are only partly understood. Here we have addressed the
role of specific intermediate filament protein partnerships in the formation of intermediate filaments in astrocytes. Astrocytes may
express three types of intermediate filament proteins: glial fibrillary
acidic protein (GFAP), vimentin, and nestin. We used mice with targeted
mutations in the GFAP or vimentin genes, or both, to study the impact
of loss of either or both of these proteins on intermediate filament
formation in cultured astrocytes and in normal or reactive astrocytes
in vivo. We report that nestin cannot form intermediate
filaments on its own, that vimentin may form intermediate filaments
with either nestin or GFAP as obligatory partners, and that GFAP is the
only intermediate filament protein of the three that may form filaments
on its own. However, such filaments show abnormal organization.
Aberrant intermediate filament formation is linked to diseases
affecting epithelial, neuronal, and muscle cells. Here we present
models by which the normal and pathogenic functions of intermediate
filaments may be elucidated in astrocytes.
Department of Medical Biochemistry,
University of Gothenburg, SE-405 30 Gothenburg, Sweden, the
§ Department of Biology, Åbo Akademi University, Turku
20520, Finland, the ¶ Department of Anatomy and Cell Biology,
University of Gothenburg, SE-405 30 Gothenburg, Sweden, the
Danish Center for Human Genome Research, Aarhus 8000, Denmark,
and the ** Turku Centre for Biotechnology, University of Turku and Åbo
Akademi University, Turku 20520, Finland
This article has been cited by other articles:
|
|
 |
|
  M. Pedrazzi, M. Patrone, M. Passalacqua, E. Ranzato, D. Colamassaro, B. Sparatore, S. Pontremoli, and E. Melloni Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling J. Immunol., December 15, 2007; 179(12): 8525 - 8532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Jing, U. Wilhelmsson, W. Goodwill, L. Li, Y. Pan, M. Pekny, and O. Skalli Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks J. Cell Sci., April 1, 2007; 120(7): 1267 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Barrett, E. Ivanova, E S. Graham, A. W Ross, D. Wilson, H. Ple, J. G Mercer, F. J Ebling, S. Schuhler, S. M Dupre, et al. Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster J. Endocrinol., December 1, 2006; 191(3): 687 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kawamoto, I. Akiguchi, H. Tomimoto, Y. Shirakashi, Y. Honjo, and H. Budka Upregulated Expression of 14-3-3 Proteins in Astrocytes From Human Cerebrovascular Ischemic Lesions Stroke, March 1, 2006; 37(3): 830 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Krylyshkina, J. Chen, L. Mebis, C. Denef, and H. Vankelecom Nestin-Immunoreactive Cells in Rat Pituitary Are neither Hormonal nor Typical Folliculo-Stellate Cells Endocrinology, May 1, 2005; 146(5): 2376 - 2387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Angelastro, J. L. Mason, T. N. Ignatova, V. G. Kukekov, G. B. Stengren, J. E. Goldman, and L. A. Greene Downregulation of Activating Transcription Factor 5 Is Required for Differentiation of Neural Progenitor Cells into Astrocytes J. Neurosci., April 13, 2005; 25(15): 3889 - 3899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Nielsen and A. L. Jorgensen Self-assembly of the Cytoskeletal Glial Fibrillary Acidic Protein Is Inhibited by an Isoform-specific C Terminus J. Biol. Chem., October 1, 2004; 279(40): 41537 - 41545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-i. Satoh, T. Yamamura, and K. Arima The 14-3-3 Protein {epsilon} Isoform Expressed in Reactive Astrocytes in Demyelinating Lesions of Multiple Sclerosis Binds to Vimentin and Glial Fibrillary Acidic Protein in Cultured Human Astrocytes Am. J. Pathol., August 1, 2004; 165(2): 577 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lundkvist, A. Reichenbach, C. Betsholtz, P. Carmeliet, H. Wolburg, and M. Pekny Under stress, the absence of intermediate filaments from Muller cells in the retina has structural and functional consequences J. Cell Sci., July 15, 2004; 117(16): 3481 - 3488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Der Perng, S. F. Wen, P. van den IJssel, A. R. Prescott, and R. A. Quinlan Desmin Aggregate Formation by R120G {alpha}B-Crystallin Is Caused by Altered Filament Interactions and Is Dependent upon Network Status in Cells Mol. Biol. Cell, May 1, 2004; 15(5): 2335 - 2346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. T. Helfand, M. G. Mendez, J. Pugh, C. Delsert, and R. D. Goldman A Role for Intermediate Filaments in Determining and Maintaining the Shape of Nerve Cells Mol. Biol. Cell, December 1, 2003; 14(12): 5069 - 5081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Klein, Z. Ling, H. Heimberg, O. D. Madsen, R. S. Heller, and P. Serup Nestin Is Expressed in Vascular Endothelial Cells in the Adult Human Pancreas J. Histochem. Cytochem., June 1, 2003; 51(6): 697 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Imura, H. I. Kornblum, and M. V. Sofroniew The Predominant Neural Stem Cell Isolated from Postnatal and Adult Forebrain But Not Early Embryonic Forebrain Expresses GFAP J. Neurosci., April 1, 2003; 23(7): 2824 - 2832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Chou, S. Khuon, H. Herrmann, and R. D. Goldman Nestin Promotes the Phosphorylation-dependent Disassembly of Vimentin Intermediate Filaments During Mitosis Mol. Biol. Cell, April 1, 2003; 14(4): 1468 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takemura, H. Gomi, E. Colucci-Guyon, and S. Itohara Protective Role of Phosphorylation in Turnover of Glial Fibrillary Acidic Protein in Mice J. Neurosci., August 15, 2002; 22(16): 6972 - 6979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Menet, M. Gimenez y Ribotta, N. Chauvet, M. J. Drian, J. Lannoy, E. Colucci-Guyon, and A. Privat Inactivation of the Glial Fibrillary Acidic Protein Gene, But Not That of Vimentin, Improves Neuronal Survival and Neurite Growth by Modifying Adhesion Molecule Expression J. Neurosci., August 15, 2001; 21(16): 6147 - 6158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Goldman Worms reveal essential functions for intermediate filaments PNAS, July 3, 2001; 98(14): 7659 - 7661. [Full Text] [PDF]
|
|
|
|
|
|
S. Schweitzer, M. Klymkowsky, R. Bellin, R. Robson, Y Capetanaki, and R. Evans Paranemin and the organization of desmin filament networks J. Cell Sci., January 3, 2001; 114(6): 1079 - 1089. [Abstract] [PDF]
|
|
|
|
|
|
C. M. Sahlgren, A. Mikhailov, J. Hellman, Y.-H. Chou, U. Lendahl, R. D. Goldman, and J. E. Eriksson Mitotic Reorganization of the Intermediate Filament Protein Nestin Involves Phosphorylation by cdc2 Kinase J. Biol. Chem., May 4, 2001; 276(19): 16456 - 16463. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
