| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 274, Issue 35, 24453-24456, August 27, 1999
,
, and
From the Presynaptic voltage-gated calcium
(Ca2+) channels mediate Ca2+ influx into the
presynaptic terminal that triggers synaptic vesicle fusion and
neurotransmitter release. The immediate proximity of Ca2+
channels to the synaptic vesicle release apparatus is critical for
rapid and efficient synaptic transmission. In a series of biochemical
experiments, we demonstrate a specific association of the cytosolic
carboxyl terminus of the N-type Ca2+ channel pore-forming
Department of Physiology, ¶ Center for
Basic Neuroscience and the Howard Hughes Medical Institute,
University of Texas Southwestern Medical Center,
Dallas, Texas 75235
1B subunit with the modular adaptor proteins Mint1 and
CASK. The carboxyl termini of 1B bind to the first PDZ
domain of Mint1 (Mint1-1). The proline-rich region present in the
carboxyl termini of 1B binds to the SH3 domain of CASK. Mint1-1 is specific for the E/D-X-W-C/S-COOH consensus,
which defines a novel class of PDZ domains (class III). The Mint1-1 PDZ
domain-binding motif is present only in the "long"
carboxyl-terminal splice variants of N-type (1B) and
P/Q-type (1A) Ca2+ channels, but not in
R-type (1E) or L-type (1C)
Ca2+ channels. Our results directly link presynaptic
Ca2+ channels to a macromolecular complex formed by modular
adaptor proteins at synaptic junction and advance our understanding of coupling between cell adhesion and synaptic vesicle exocytosis.
This article has been cited by other articles:
|
|
 |
|
  R. N. Saha and S. M. Dudek Action Potentials: To the Nucleus and Beyond Experimental Biology and Medicine, April 1, 2008; 233(4): 385 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Altier, C. S. Dale, A. E. Kisilevsky, K. Chapman, A. J. Castiglioni, E. A. Matthews, R. M. Evans, A. H. Dickenson, D. Lipscombe, N. Vergnolle, et al. Differential Role of N-Type Calcium Channel Splice Isoforms in Pain J. Neurosci., June 13, 2007; 27(24): 6363 - 6373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Atasoy, S. Schoch, A. Ho, K. A. Nadasy, X. Liu, W. Zhang, K. Mukherjee, E. D. Nosyreva, R. Fernandez-Chacon, M. Missler, et al. Deletion of CASK in mice is lethal and impairs synaptic function PNAS, February 13, 2007; 104(7): 2525 - 2530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Calin-Jageman, K. Yu, R. A. Hall, L. Mei, and A. Lee Erbin Enhances Voltage-Dependent Facilitation of Cav1.3 Ca2+ Channels through Relief of an Autoinhibitory Domain in the Cav1.3 {alpha}1 Subunit J. Neurosci., February 7, 2007; 27(6): 1374 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ho, W. Morishita, D. Atasoy, X. Liu, K. Tabuchi, R. E. Hammer, R. C. Malenka, and T. C. Sudhof Genetic Analysis of Mint/X11 Proteins: Essential Presynaptic Functions of a Neuronal Adaptor Protein Family J. Neurosci., December 13, 2006; 26(50): 13089 - 13101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dudanova, S. Sedej, M. Ahmad, H. Masius, V. Sargsyan, W. Zhang, D. Riedel, F. Angenstein, D. Schild, M. Rupnik, et al. Important Contribution of {alpha}-Neurexins to Ca2+-Triggered Exocytosis of Secretory Granules J. Neurosci., October 11, 2006; 26(41): 10599 - 10613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Castiglioni, J. Raingo, and D. Lipscombe Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels J. Physiol., October 1, 2006; 576(1): 119 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maguy, T. E. Hebert, and S. Nattel Involvement of lipid rafts and caveolae in cardiac ion channel function Cardiovasc Res, March 1, 2006; 69(4): 798 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kanumilli, E. W. Tringham, C. Elizabeth Payne, J. R. B. Dupere, K. Venkateswarlu, and M. M. Usowicz Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum Physiol Genomics, January 12, 2006; 24(2): 86 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chaudhuri, B. A. Alseikhan, S. Y. Chang, T. W. Soong, and D. T. Yue Developmental Activation of Calmodulin-Dependent Facilitation of Cerebellar P-Type Ca2+ Current J. Neurosci., September 7, 2005; 25(36): 8282 - 8294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Marble, A. P. Hegle, E. D. Snyder II, S. Dimitratos, P. J. Bryant, and G. F. Wilson Camguk/CASK Enhances Ether-A-Go-Go Potassium Current by a Phosphorylation-Dependent Mechanism J. Neurosci., May 18, 2005; 25(20): 4898 - 4907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Xie, D. M. Romano, and R. E. Tanzi RNA Interference-mediated Silencing of X11{alpha} and X11{beta} Attenuates Amyloid {beta}-Protein Levels via Differential Effects on {beta}-Amyloid Precursor Protein Processing J. Biol. Chem., April 15, 2005; 280(15): 15413 - 15421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, A. Maximov, Y. Fu, F. Xu, T.-S. Tang, T. Tkatch, D. J. Surmeier, and I. Bezprozvanny Association of CaV1.3 L-Type Calcium Channels with Shank J. Neurosci., February 2, 2005; 25(5): 1037 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Olson, T. Tkatch, S. Hernandez-Lopez, S. Ulrich, E. Ilijic, E. Mugnaini, H. Zhang, I. Bezprozvanny, and D. J. Surmeier G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+ Channels Is Dependent on a Shank-Binding Domain J. Neurosci., February 2, 2005; 25(5): 1050 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Hu, H. Saegusa, Y. Hayashi, and T. Tanabe The carboxy-terminal tail region of human Cav2.1 (P/Q-type) channel is not an essential determinant for its subcellular localization in cultured neurones Genes Cells, February 1, 2005; 10(2): 87 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Zhai and H. J. Bellen The Architecture of the Active Zone in the Presynaptic Nerve Terminal Physiology, October 1, 2004; 19(5): 262 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chaudhuri, S.-Y. Chang, C. D. DeMaria, R. S. Alvania, T. W. Soong, and D. T. Yue Alternative Splicing as a Molecular Switch for Ca2+/Calmodulin-Dependent Facilitation of P/Q-Type Ca2+ Channels J. Neurosci., July 14, 2004; 24(28): 6334 - 6342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Leonoudakis, L. R. Conti, C. M. Radeke, L. M. M. McGuire, and C. A. Vandenberg A Multiprotein Trafficking Complex Composed of SAP97, CASK, Veli, and Mint1 Is Associated with Inward Rectifier Kir2 Potassium Channels J. Biol. Chem., April 30, 2004; 279(18): 19051 - 19063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tu, T.-S. Tang, Z. Wang, and I. Bezprozvanny Association of Type 1 Inositol 1,4,5-Trisphosphate Receptor with AKAP9 (Yotiao) and Protein Kinase A J. Biol. Chem., April 30, 2004; 279(18): 19375 - 19382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kattenstroth, E. Tantalaki, T. C. Sudhof, K. Gottmann, and M. Missler Postsynaptic N-methyl-D-aspartate receptor function requires {alpha}-neurexins PNAS, February 24, 2004; 101(8): 2607 - 2612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Taverna, E. Saba, J. Rowe, M. Francolini, F. Clementi, and P. Rosa Role of Lipid Microdomains in P/Q-type Calcium Channel (Cav2.1) Clustering and Function in Presynaptic Membranes J. Biol. Chem., February 13, 2004; 279(7): 5127 - 5134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lesage, H. Hibino, and A. J. Hudspeth Association of {beta}-catenin with the {alpha}-subunit of neuronal large-conductance Ca2+-activated K+ channels PNAS, January 13, 2004; 101(2): 671 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Lee, K.-F. Lau, M. S. Perkinton, C. L. Standen, S. J. A. Shemilt, L. Mercken, J. D. Cooper, D. M. McLoughlin, and C. C. J. Miller The Neuronal Adaptor Protein X11{alpha} Reduces A{beta} Levels in the Brains of Alzheimer's APPswe Tg2576 Transgenic Mice J. Biol. Chem., November 21, 2003; 278(47): 47025 - 47029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hill, Y. Li, M. Bennett, M. McKay, X. Zhu, J. Shern, E. Torre, J. J. Lah, A. I. Levey, and R. A. Kahn Munc18 Interacting Proteins: ADP-RIBOSYLATION FACTOR-DEPENDENT COAT PROTEINS THAT REGULATE THE TRAFFIC OF {beta}-ALZHEIMER'S PRECURSOR PROTEIN J. Biol. Chem., September 19, 2003; 278(38): 36032 - 36040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. PLOMP, A. M. VAN DEN MAAGDENBERG, M. D. FERRARI, R. R. FRANTS, and P. C. MOLENAAR Transmitter Release Deficits at the Neuromuscular Synapse of Mice with Mutations in the Cav2.1 ({alpha}1A) Subunit of the P/Q-Type Ca2+ Channel Ann. N.Y. Acad. Sci., September 1, 2003; 998(1): 29 - 32. [Full Text] [PDF]
|
|
|
|
|
|
C. Millan, E. Castro, M. Torres, R. Shigemoto, and J. Sanchez-Prieto Co-expression of Metabotropic Glutamate Receptor 7 and N-type Ca2+ Channels in Single Cerebrocortical Nerve Terminals of Adult Rats J. Biol. Chem., June 20, 2003; 278(26): 23955 - 23962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Weick, R. D. Groth, A. L. Isaksen, and P. G. Mermelstein Interactions with PDZ Proteins Are Required for L-Type Calcium Channels to Activate cAMP Response Element-Binding Protein-Dependent Gene Expression J. Neurosci., April 15, 2003; 23(8): 3446 - 3456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. J. Im, S. H. Park, S.-H. Rho, J. H. Lee, G. B. Kang, M. Sheng, E. Kim, and S. H. Eom Crystal Structure of GRIP1 PDZ6-Peptide Complex Reveals the Structural Basis for Class II PDZ Target Recognition and PDZ Domain-mediated Multimerization J. Biol. Chem., February 28, 2003; 278(10): 8501 - 8507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ho, W. Morishita, R. E. Hammer, R. C. Malenka, and T. C. Sudhof A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission PNAS, February 4, 2003; 100(3): 1409 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Spafford, D. W. Munno, P. van Nierop, Z.-P. Feng, S. E. Jarvis, W. J. Gallin, A. B. Smit, G. W. Zamponi, and N. I. Syed Calcium Channel Structural Determinants of Synaptic Transmission between Identified Invertebrate Neurons J. Biol. Chem., January 31, 2003; 278(6): 4258 - 4267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-S. Tang, H. Tu, Z. Wang, and I. Bezprozvanny Modulation of Type 1 Inositol (1,4,5)-Trisphosphate Receptor Function by Protein Kinase A and Protein Phosphatase 1alpha J. Neurosci., January 15, 2003; 23(2): 403 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Soong, C. D. DeMaria, R. S. Alvania, L. S. Zweifel, M. C. Liang, S. Mittman, W. S. Agnew, and D. T. Yue Systematic Identification of Splice Variants in Human P/Q-Type Channel alpha 12.1 Subunits: Implications for Current Density and Ca2+-Dependent Inactivation J. Neurosci., December 1, 2002; 22(23): 10142 - 10152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Nitabach, D. A. Llamas, I. J. Thompson, K. A. Collins, and T. C. Holmes Phosphorylation-Dependent and Phosphorylation-Independent Modes of Modulation of Shaker Family Voltage-Gated Potassium Channels by Src Family Protein Tyrosine Kinases J. Neurosci., September 15, 2002; 22(18): 7913 - 7922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maximov and I. Bezprozvanny Synaptic Targeting of N-Type Calcium Channels in Hippocampal Neurons J. Neurosci., August 15, 2002; 22(16): 6939 - 6952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tabuchi, T. Biederer, S. Butz, and T. C. Sudhof CASK Participates in Alternative Tripartite Complexes in which Mint 1 Competes for Binding with Caskin 1, a Novel CASK-Binding Protein J. Neurosci., June 1, 2002; 22(11): 4264 - 4273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Z. Harris and W. A. Lim Mechanism and role of PDZ domains in signaling complex assembly J. Cell Sci., March 11, 2002; 114(18): 3219 - 3231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Piserchio, M. Pellegrini, S. Mehta, S. M. Blackman, E. P. Garcia, J. Marshall, and D. F. Mierke The PDZ1 Domain of SAP90. CHARACTERIZATION OF STRUCTURE AND BINDING J. Biol. Chem., February 22, 2002; 277(9): 6967 - 6973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsunemi, H. Saegusa, K. Ishikawa, S. Nagayama, T. Murakoshi, H. Mizusawa, and T. Tanabe Novel Cav2.1 Splice Variants Isolated from Purkinje Cells Do Not Generate P-type Ca2+ Current J. Biol. Chem., February 22, 2002; 277(9): 7214 - 7221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kitano, K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, and S. Nakanishi Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins J. Neurosci., February 15, 2002; 22(4): 1280 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Vaccaro, B. Brannetti, L. Montecchi-Palazzi, S. Philipp, M. H. Citterich, G. Cesareni, and L. Dente Distinct Binding Specificity of the Multiple PDZ Domains of INADL, a Human Protein with Homology to INAD from Drosophila melanogaster J. Biol. Chem., November 2, 2001; 276(45): 42122 - 42130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Davis, X. Wu, T. R. Nurkiewicz, J. Kawasaki, P. Gui, M. A. Hill, and E. Wilson Regulation of ion channels by protein tyrosine phosphorylation Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H1835 - H1862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Simen, C. C. Lee, B. B. Simen, V. P. Bindokas, and R. J. Miller The C Terminus of the Ca Channel {alpha}1B Subunit Mediates Selective Inhibition by G-Protein-Coupled Receptors J. Neurosci., October 1, 2001; 21(19): 7587 - 7597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Tao and M.-m. Poo Retrograde signaling at central synapses PNAS, September 25, 2001; 98(20): 11009 - 11015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Venter, M. D. Adams, E. W. Myers, P. W. Li, R. J. Mural, G. G. Sutton, H. O. Smith, M. Yandell, C. A. Evans, R. A. Holt, et al. The Sequence of the Human Genome Science, February 16, 2001; 291(5507): 1304 - 1351. [Abstract] [Full Text]
|
|
|
|
|
|
I. Bezprozvanny and A. Maximov PDZ domains: More than just a glue PNAS, January 30, 2001; 98(3): 787 - 789. [Full Text] [PDF]
|
|
|
|
|
|
M. N. Nitabach, D. A. Llamas, R. C. Araneda, J. L. Intile, I. J. Thompson, Y. I. Zhou, and T. C. Holmes A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors PNAS, January 5, 2001; (2001) 31446198. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. S. Lee, B. Glaunsinger, F. Mantovani, L. Banks, and R. T. Javier Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins J. Virol., October 15, 2000; 74(20): 9680 - 9693. [Abstract] [Full Text]
|
|
|
|
|
|
B. L. Gerhardstein, T. Gao, M. Bunemann, T. S. Puri, A. Adair, H. Ma, and M. M. Hosey Proteolytic Processing of the C Terminus of the alpha 1C Subunit of L-type Calcium Channels and the Role of a Proline-rich Domain in Membrane Tethering of Proteolytic Fragments J. Biol. Chem., March 17, 2000; 275(12): 8556 - 8563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B De Strooper and W Annaert Proteolytic processing and cell biological functions of the amyloid precursor protein J. Cell Sci., January 6, 2000; 113(11): 1857 - 1870. [Abstract] [PDF]
|
|
|
|
|
|
T. Biederer and T. C. Sudhof Mints as Adaptors. DIRECT BINDING TO NEUREXINS AND RECRUITMENT OF Munc18 J. Biol. Chem., December 15, 2000; 275(51): 39803 - 39806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Nix, A. H. Chishti, J. M. Anderson, and Z. Walther hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions J. Biol. Chem., December 22, 2000; 275(52): 41192 - 41200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Minopoli, P. de Candia, A. Bonetti, R. Faraonio, N. Zambrano, and T. Russo The beta -Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear Translocation J. Biol. Chem., February 23, 2001; 276(9): 6545 - 6550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Mueller, J.-P. Borg, B. Margolis, and R. S. Turner Modulation of Amyloid Precursor Protein Metabolism by X11alpha /Mint-1. A DELETION ANALYSIS OF PROTEIN-PROTEIN INTERACTION DOMAINS J. Biol. Chem., December 8, 2000; 275(50): 39302 - 39306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. McLoughlin, C. L. Standen, K.-F. Lau, S. Ackerley, T. P. Bartnikas, J. D. Gitlin, and C. C. J. Miller The Neuronal Adaptor Protein X11alpha Interacts with the Copper Chaperone for SOD1 and Regulates SOD1 Activity J. Biol. Chem., March 16, 2001; 276(12): 9303 - 9307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Duggan, J. Garcia-Anoveros, and D. P. Corey The PDZ Domain Protein PICK1 and the Sodium Channel BNaC1 Interact and Localize at Mechanosensory Terminals of Dorsal Root Ganglion Neurons and Dendrites of Central Neurons J. Biol. Chem., February 8, 2002; 277(7): 5203 - 5208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Nitabach, D. A. Llamas, R. C. Araneda, J. L. Intile, I. J. Thompson, Y. I. Zhou, and T. C. Holmes A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors PNAS, January 16, 2001; 98(2): 705 - 710. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
