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J Biol Chem, Vol. 274, Issue 35, 24575-24578, August 27, 1999
From the Departments of Psychiatry and Cellular & Molecular
Pharmacology, Program in Cell Biology, University of California,
San Francisco, California 94143-0984
Dynamin plays a critical role in the membrane
fission mechanism that mediates regulated endocytosis of many G
protein-coupled receptors. In addition, dynamin is required for
ligand-induced activation of mitogen-activated protein kinase by
certain receptors, raising a general question about the role of dynamin
in mitogenic signal transduction. Here we report that endocytosis of µ and 
opioid receptors is not required for efficient
ligand-induced activation of mitogen-activated protein kinase.
Nevertheless, mitogenic signaling mediated by these receptors is
specifically dynamin-dependent. Thus a functional role of
dynamin in mitogenic signaling can be dissociated from its role in
receptor-mediated endocytosis, suggesting a previously unidentified and
distinct role of dynamin in signal transduction by certain G
protein-coupled receptors.
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