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J Biol Chem, Vol. 274, Issue 35, 24766-24772, August 27, 1999
From the Oncostatin M (OSM) is a member of the IL-6 family
cytokines that use gp130 as a common signal transducer and exhibits
both growth stimulatory as well as growth inhibitory activity depending on the cells. To analyze the mechanism of OSM function, we isolated immediate early responsive genes upon OSM stimulation. Here we describe
the novel OSM-inducible gene OIG37 that is related to MyD118 and
GADD45. The MyD118 gene has been described as an immediate early gene
induced by IL-6 in M1 monocytic cells, and GADD45 was identified as a
gene induced by UV or
A Novel Oncostatin M-inducible Gene OIG37 Forms a Gene Family
with MyD118 and GADD45 and Negatively Regulates Cell Growth
,
,
Institute of Molecular and Cellular
Biosciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
and the § Osaka University School of Medicine,
Suita-shi 565-0871, Japan
-ray irradiation. Both are considered to
function in growth arrest and/or DNA repair. Although the expression of
OIG37, MyD118, and GADD45 was rather ubiquitous, it was differentially
regulated. As the gp130 mutant defective for activating the STAT3
pathway showed the reduced induction of OIG37 by cytokine stimulation
and expression of dominant negative STAT3 inhibited the induction of
OIG37 by OSM, STAT3 is involved in OIG37 induction by IL-6 family
cytokines. To examine the function of OIG37, we expressed it in NIH3T3
and IL-3-dependent BaF3 cells and found that OIG37
suppressed cell growth without any evidence of apoptosis. Whereas both
MyD118 and OIG37 suppressed cell growth in both cell lines, suppression
by OIG37 was more efficient than by MyD118. Immunoprecipitation
experiments indicated that OIG37 associates with p21, a
cyclin-dependent kinase inhibitor, and proliferating cell nuclear antigen.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
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