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J Biol Chem, Vol. 274, Issue 37, 25963-25966, September 10, 1999
,,,,¶
From the Departments of Exocytosis of synaptic vesicles is
calcium-dependent, with synaptotagmin serving as the
calcium sensor. Endocytosis of synaptic vesicles has also been
postulated as a calcium-dependent process; however, an
endocytic calcium sensor has not been found. We now report a physical
association between the calcium-dependent phosphatase calcineurin and dynamin 1, a component of the synaptic endocytic machinery. The calcineurin-dynamin 1 interaction is
calcium-dependent, with an EC50 for
calcium in the range of 0.1-0.4 µM. Disruption of the
calcineurin-dynamin 1 interaction inhibits clathrin-mediated endocytosis. Thus, the calcium-dependent formation of the
calcineurin-dynamin 1 complex, delivered to the other endocytic coat
proteins, provides a calcium-sensing mechanism that facilitates endocytosis.
Neuroscience,
¶ Pharmacology and Molecular Sciences, and Psychiatry,
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and the § Howard Hughes Medical Institute and Department of
Cell Biology, Yale University School of Medicine,
New Haven, Connecticut 06510
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